Influence of the long-term Trypanosoma cruzi infection in vertebrate host on the genetic and biological diversity of the parasite

2005 ◽  
Vol 96 (6) ◽  
pp. 382-389 ◽  
Author(s):  
V. M. Veloso ◽  
A. J. Romanha ◽  
M. Lana ◽  
S. M. F. Murta ◽  
C. M. Carneiro ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Biological Diversity ◽  
Vertebrate Host ◽  
Cruzi Infection

Impact of clonal evolution on the biological diversity of Trypanosoma cruzi

Parasitology ◽  
1997 ◽  
Vol 114 (3) ◽  
pp. 213-218 ◽  
Author(s):  
J.-P. LAURENT ◽  
C. BARNABE ◽  
V. QUESNEY ◽  
S. NOEL ◽  
M. TIBAYRENC
Keyword(s):  
Trypanosoma Cruzi ◽  
Biological Diversity ◽  
Clonal Evolution ◽  
Evolutionary Divergence ◽  
Biological Variability ◽  
Profound Impact ◽  
Applied Study ◽  
Biological Differences

Trypanosoma cruzi, the agent of Chagas' disease, exhibits considerable biological variability. Moreover, it has been postulated that populations of this protozoan are subdivided into natural clones, which can be separated from each other by considerable levels of evolutionary divergence. The authors have proposed that this long-term clonal evolution may have a profound impact on Trypanosoma cruzi biological diversity. In order to test this hypothesis, 16 T. cruzi stocks representing 3 major clonal genotypes of the parasite were analysed for 8 different in vitro biological parameters. The overall results show a strong statistical linkage between genetic and biological differences. This is in agreement with the working hypothesis, although a notable biological variability is observable among the stocks of each of the 3 major clonal genotypes. The authors propose that T. cruzi genetic variability must be taken into account in any applied study dealing with this parasite.

scholarly journals Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole

2020 ◽  
Vol 14 (9) ◽  
pp. e0008726
Author(s):  
Claudia Magalhães Calvet ◽  
Tatiana Araújo Silva ◽  
Diane Thomas ◽  
Brian Suzuki ◽  
Ken Hirata ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Long Term Follow Up ◽  
Cruzi Infection

scholarly journals Comparison of Trypanosoma cruzi infection in dogs inoculated with blood or metacyclic trypomastigotes of Berenice-62 and Berenice-78 strains via intraperitoneal and conjunctival routes

2002 ◽  
Vol 35 (4) ◽  
pp. 339-345 ◽  
Author(s):  
Maria Terezinha Bahia ◽  
Washington Luiz Tafuri ◽  
Marcelo Vidigal Caliari ◽  
Vanja Maria Veloso ◽  
Cláudia Martins Carneiro ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Acute Myocarditis ◽  
The Other ◽  
Vertebrate Host ◽  
Inoculum Source ◽  
Intraperitoneal Route ◽  
Metacyclic Trypomastigotes ◽  
High Level ◽  
Cruzi Infection ◽  
Metacyclic Trypomastigote

This paper aimed to verify the influence of the inoculum source (blood or metacyclic trypomastigote) and the route of inoculation (intraperitoneal or conjunctival) on the course of T. cruzi infection in dogs, using comparatively the T. cruzi strains Berenice-62 and Berenice-78. All dogs inoculated intraperitoneally became infected independently of the T. cruzi strain and source of trypomastigotes used. High level of infectivity was also observed when metacyclic trypomastigotes of both strains were inoculated by conjunctival route. However, when blood trypomastigotes were inoculated by conjunctival route the percentages of infectivity were significantly lower in dogs inoculated with both strains. Parasitaemia was significantly higher in animals infected with metacyclic trypomastigotes via the conjunctival route independently of the T. cruzi strain used. All animals infected with Berenice-78 strain showed severe acute myocarditis. On the other hand, animals infected with Berenice-62 showed severe acute myocarditis only when infected with metacyclic trypomastigote, via the intraperitoneal route. The results suggest that the source of the inoculum and the route of inoculation remarkably influence the evolution of the infection for the T. cruzi in the vertebrate host even when the same strain of the parasite is used.

scholarly journals Trypanosoma cruzi: Acute and long-term infection in the vertebrate host can modify the response to benznidazole

2008 ◽  
Vol 118 (3) ◽  
pp. 315-323 ◽  
Author(s):  
Sérgio Caldas ◽  
Fabiane M. Santos ◽  
Marta de Lana ◽  
Lívia F. Diniz ◽  
George L.L. Machado-Coelho ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vertebrate Host

scholarly journals Long-term reduction of Trypanosoma cruzi infection in sylvatic mammals following deforestation and sustained vector surveillance in northwestern Argentina

Acta Tropica ◽  
2006 ◽  
Vol 98 (3) ◽  
pp. 286-296 ◽  
Author(s):  
L.A. Ceballos ◽  
M.V. Cardinal ◽  
G.M. Vazquez-Prokopec ◽  
M.A. Lauricella ◽  
M.M. Orozco ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Vector Surveillance ◽  
Northwestern Argentina ◽  
Cruzi Infection

scholarly journals Polyfunctional T Cell Responses in Children in Early Stages of Chronic Trypanosoma cruzi Infection Contrast with Monofunctional Responses of Long-term Infected Adults

2013 ◽  
Vol 7 (12) ◽  
pp. e2575 ◽  
Author(s):  
María C. Albareda ◽  
Ana M. De Rissio ◽  
Gonzalo Tomas ◽  
Alicia Serjan ◽  
María G. Alvarez ◽  
...  
Keyword(s):  
T Cell ◽  
Trypanosoma Cruzi ◽  
T Cell Responses ◽  
Cell Responses ◽  
Early Stages ◽  
Cruzi Infection

Tissue Reacting Antibodies in a Rhesus Monkey with Long-Term Trypanosoma Cruzi Infection *

1978 ◽  
Vol 27 (4) ◽  
pp. 832-834 ◽  
Author(s):  
A. Szarfman ◽  
L. Galvão Quintao ◽  
F. S. Laranja ◽  
W. de Souza ◽  
G. A. Schmuñis ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Rhesus Monkey ◽  
Cruzi Infection
Sign in / Sign up

Export Citation Format

Share Document