Imelda Menchaca Armenta
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Antonio E. Gutiérrez Rodríguez
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Hortencia Cortes Pérez
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Jessica Zaragoza Cortes
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Karen Zamora Cerritos
Chagas disease and type 2 diabetes mellitus are the two main causes of Years Lived with Disability. The consequences and possible interaction between both illnesses have been scarcely studied. A population study of blood donors from the Centro Estatal de Transfusión Sanguinea (CETS) was carried out with a reagent related to the Chagas test. Detection was carried out with an enzyme-linked immunosorbent assay (ELISA) of anti- Trypanosoma cruzi antibodies and also, an HbA1C test was performed with 4 mL of whole blood. Descriptive statistics were used to analyze quantitative and qualitative data. The Chi-square test was applied to determine the existence of an association between hyperglycemia and Chagas disease. A total of 4,952 participants were screened. All of the participants (100%) were from Hidalgo State and did not have a chagoma as evidence of having been bitten or denied contact with a “kissing bug”. Of the total, 26 reacted to the first screening test to detect anti-Trypanosoma cruzi antibodies; of these, five were confirmed as positive on the second screening test. The seroprevalence of T. cruzi was 0.01%. The results do not show a clear association but the frequency of hyperglycemia in population with Chagas coincides with that reported by other authors. Considering the scarce clinical–epidemiological evidence between Chagas disease, obesity, and hyperglycemia, long-term follow up of both morbidities is an area of opportunity for clinical and epidemiological study of T. cruzi reactivity.
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole
