Fibroblast growth factors and their receptors in the central nervous system

2003 ◽  
Vol 313 (2) ◽  
pp. 139-157 ◽  
Author(s):  
Bernhard Reuss ◽  
Oliver von Bohlen und Halbach
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Growth Factors ◽  
Fibroblast Growth Factors ◽  
Fibroblast Growth ◽  
The Central Nervous System

scholarly journals Astroglial and fibroblast growth factors have neurotrophic functions for cultured peripheral and central nervous system neurons.

1987 ◽  
Vol 84 (15) ◽  
pp. 5459-5463 ◽  
Author(s):  
K. Unsicker ◽  
H. Reichert-Preibsch ◽  
R. Schmidt ◽  
B. Pettmann ◽  
G. Labourdette ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Growth Factors ◽  
Fibroblast Growth Factors ◽  
Fibroblast Growth

Fibroblast growth factors as regulators of central nervous system development and function

2003 ◽  
Vol 284 (4) ◽  
pp. R867-R881 ◽  
Author(s):  
Rosanna Dono
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Growth Factors ◽  
System Development ◽  
Fibroblast Growth Factors ◽  
Brain Structures ◽  
Nervous System Development ◽  
Adult Brain ◽  
Fibroblast Growth ◽  
Fgf Signaling

Fibroblast growth factors (FGFs) are multifunctional signaling proteins that regulate developmental processes and adult physiology. Over the last few years, important progress has been made in understanding the function of FGFs in the embryonic and adult central nervous system. In this review, I will first discuss studies showing that FGF signaling is already required during formation of the neural plate. Next, I will describe how FGF signaling centers control growth and patterning of specific brain structures. Finally, I will focus on the function of FGF signaling in the adult brain and in regulating maintenance and repair of damaged neural tissues.

scholarly journals Death of developing neurons: New insights and implications for connectivity

2013 ◽  
Vol 203 (3) ◽  
pp. 385-393 ◽  
Author(s):  
Martijn P.J. Dekkers ◽  
Vassiliki Nikoletopoulou ◽  
Yves-Alain Barde
Keyword(s):  
Central Nervous System ◽  
Cell Death ◽  
Nervous System ◽  
Growth Factors ◽  
Axonal Degeneration ◽  
Neuronal Development ◽  
Critical Role ◽  
Synaptic Function ◽  
The Central Nervous System ◽  
Developing Neurons

The concept that target tissues determine the survival of neurons has inspired much of the thinking on neuronal development in vertebrates, not least because it is supported by decades of research on nerve growth factor (NGF) in the peripheral nervous system (PNS). Recent discoveries now help to understand why only some developing neurons selectively depend on NGF. They also indicate that the survival of most neurons in the central nervous system (CNS) is not simply regulated by single growth factors like in the PNS. Additionally, components of the cell death machinery have begun to be recognized as regulators of selective axonal degeneration and synaptic function, thus playing a critical role in wiring up the nervous system.

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