Chymotrypsin gene expression in rat peripheral organs

1998 ◽  
Vol 292 (2) ◽  
pp. 345-354 ◽  
Author(s):  
Xiao-Cun Wang ◽  
Kenneth I. Strauss ◽  
Quy N. Ha ◽  
Satish Nagula ◽  
Matthew E. Wolpoe ◽  
...  
PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
pp. e5650 ◽  
Author(s):  
Cathy Cailotto ◽  
Jun Lei ◽  
Jan van der Vliet ◽  
Caroline van Heijningen ◽  
Corbert G. van Eden ◽  
...  

2010 ◽  
Vol 299 (3) ◽  
pp. R751-R761 ◽  
Author(s):  
Carrie E. Mahoney ◽  
Daniel Brewer ◽  
Mary K. Costello ◽  
Judy McKinley Brewer ◽  
Eric L. Bittman

To evaluate the contribution of neural pathways to the determination of the circadian oscillator phase in peripheral organs, we assessed lateralization of clock gene expression in Syrian hamsters induced to split rhythms of locomotor activity by exposure to constant light. We measured the ratio of haPer1, haPer2, and haBmal1 mRNA on the high vs. low (H/L) side at 3-h intervals prior to the predicted activity onset (pAO). We also calculated expression on the sides ipsilateral vs. contralateral (I/C) to the side of the suprachiasmatic nucleus (SCN) expressing higher haPer1. The extent of asymmetry in split hamsters varied between specific genes, phases, and organs. Although the magnitude of asymmetry in peripheral organs was never as great as that in the SCN, we observed significantly greater lateralization of clock gene expression in the adrenal medulla and cortex, lung, and skeletal muscle, but not in liver or kidney, of split hamsters than of unsplit controls. We observed fivefold lateralization of expression of the clock-controlled gene, albumin site D-element binding protein ( Dbp), in skeletal muscle (H/L: 10.7 ± 3.7 at 3 h vs. 2.2 ± 0.3 at 0 h pAO; P = 0.03). Furthermore, tyrosine hydroxylase expression was asymmetrical in the adrenal medulla of split (H/L: 1.9 ± 0.5 at 0 h) vs. unsplit hamsters (1.2 ± 0.04; P < 0.05). Consistent with a model of neurally controlled gene expression, we found significant correlations between the phase angle between morning and evening components (ψme) and the level of asymmetry (H/L or I/C). Our results indicate that neural pathways contribute to, but cannot completely account for, SCN regulation of the phase of peripheral oscillators.


2005 ◽  
Vol 16 (1) ◽  
pp. 55-65 ◽  
Author(s):  
Zhang-Yong Ning ◽  
De-Ming Zhao ◽  
Jian-Min Yang ◽  
Ya-Li Cui ◽  
Li-Ping Meng ◽  
...  

2011 ◽  
Vol 26 (3) ◽  
pp. 200-209 ◽  
Author(s):  
Dawn H. Loh ◽  
Joanna M. Dragich ◽  
Takashi Kudo ◽  
Analyne M. Schroeder ◽  
Takahiro J. Nakamura ◽  
...  

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1952-P
Author(s):  
CHANG HO AHN ◽  
SUN JOON MOON ◽  
YOUNG MIN CHO

2006 ◽  
Vol 27 (1) ◽  
pp. 18-19
Author(s):  
Eric L. Bittman ◽  
Anastasia Nikiforov ◽  
Ruth Harris ◽  
Judy McKinley Brewer

2015 ◽  
Vol 22 (4) ◽  
pp. 263-273 ◽  
Author(s):  
Claudio Alberto Mastronardi ◽  
Gilberto Paz-Filho ◽  
Martina Zanoni ◽  
Nicolas Molano-González ◽  
Mauricio Arcos-Burgos ◽  
...  

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