scholarly journals Suprachiasmatic Regulation of Circadian Rhythms of Gene Expression in Hamster Peripheral Organs: Effects of Transplanting the Pacemaker

2006 ◽  
Vol 26 (24) ◽  
pp. 6406-6412 ◽  
Author(s):  
H. Guo ◽  
J. M. Brewer ◽  
M. N. Lehman ◽  
E. L. Bittman
Keyword(s):  
Gene Expression ◽  
Circadian Rhythms ◽  
Peripheral Organs

Role of non-neural signals in regulation of circadian rhythms of core clock gene expression in mouse peripheral organs

2006 ◽  
Vol 27 (1) ◽  
pp. 18-19
Author(s):  
Eric L. Bittman ◽  
Anastasia Nikiforov ◽  
Ruth Harris ◽  
Judy McKinley Brewer
Keyword(s):  
Gene Expression ◽  
Circadian Rhythms ◽  
Clock Gene ◽  
Neural Signals ◽  
Peripheral Organs ◽  
Clock Gene Expression ◽  
Core Clock Gene

Melatonin: a novel strategy for prevention of obesity and fat accumulation in peripheral organs through the improvements of circadian rhythms and antioxidative capacity

2020 ◽  
Vol 3 (1) ◽  
pp. 58-76 ◽  
Author(s):  
Bohan Rong ◽  
Qiong Wu ◽  
Chao Sun
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Circadian Rhythms ◽  
Regulatory Mechanisms ◽  
Antioxidative Capacity ◽  
Unicellular Alga ◽  
Peripheral Tissues ◽  
Peripheral Organs ◽  
Regulatory Effects ◽  
Novel Strategy

Melatonin is a well-known molecule for its involvement in circadian rhythm regulation and its contribution to protection against oxidative stress in organisms including unicellular alga, animals and plants. Currently, the bio-regulatory effects of melatonin on the physiology of various peripheral tissues have drawn a great attention of scientists. Although melatonin was previously defined as a neurohormone secreted from pineal gland, recently it has been identified that virtually, every cell has the capacity to synthesize melatonin and the locally generated melatonin has multiple pathophysiological functions, including regulations of obesity and metabolic syndromes. Herein, we focus on the effects of melatonin on fat deposition in various peripheral organs/tissues. The two important regulatory mechanisms related to the topic, i.e., the improvements of circadian rhythms and antioxidative capacity will be thoroughly discussed since they are linked to several biomarkers involved in obesity and energy imbalance, including metabolism and immunity. Furthermore, several other functions of melatonin which may serve to prevent or promote obesity and energy dysmetabolism-induced pathological states are also addressed. The organs of special interest include liver, pancreas, skeletal muscle, adipose tissue and the gut microbiota.

Chymotrypsin gene expression in rat peripheral organs

1998 ◽  
Vol 292 (2) ◽  
pp. 345-354 ◽  
Author(s):  
Xiao-Cun Wang ◽  
Kenneth I. Strauss ◽  
Quy N. Ha ◽  
Satish Nagula ◽  
Matthew E. Wolpoe ◽  
...  
Keyword(s):  
Gene Expression ◽  
Peripheral Organs

The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression

Neuron ◽  
1991 ◽  
Vol 6 (5) ◽  
pp. 753-766 ◽  
Author(s):  
Xin Liu ◽  
Qiang Yu ◽  
Zuoshi Huang ◽  
Laurence J. Zwiebel ◽  
Jeffrey C. Hall ◽  
...  
Keyword(s):  
Gene Expression ◽  
Circadian Rhythms ◽  
Period Gene

scholarly journals Casein Kinase 1 Underlies Temperature Compensation of Circadian Rhythms in Human Red Blood Cells

2019 ◽  
Vol 34 (2) ◽  
pp. 144-153 ◽  
Author(s):  
Andrew D. Beale ◽  
Emily Kruchek ◽  
Stephen J. Kitcatt ◽  
Erin A. Henslee ◽  
Jack S.W. Parry ◽  
...  
Keyword(s):  
Gene Expression ◽  
Circadian Rhythms ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Temperature Compensation ◽  
Clock Gene ◽  
Cell Types ◽  
Casein Kinase ◽  
Casein Kinase 1 ◽  
Human Red Blood Cells

Temperature compensation and period determination by casein kinase 1 (CK1) are conserved features of eukaryotic circadian rhythms, whereas the clock gene transcription factors that facilitate daily gene expression rhythms differ between phylogenetic kingdoms. Human red blood cells (RBCs) exhibit temperature-compensated circadian rhythms, which, because RBCs lack nuclei, must occur in the absence of a circadian transcription-translation feedback loop. We tested whether period determination and temperature compensation are dependent on CKs in RBCs. As with nucleated cell types, broad-spectrum kinase inhibition with staurosporine lengthened the period of the RBC clock at 37°C, with more specific inhibition of CK1 and CK2 also eliciting robust changes in circadian period. Strikingly, inhibition of CK1 abolished temperature compensation and increased the Q10 for the period of oscillation in RBCs, similar to observations in nucleated cells. This indicates that CK1 activity is essential for circadian rhythms irrespective of the presence or absence of clock gene expression cycles.

scholarly journals Effects of Nocturnal Light on (Clock) Gene Expression in Peripheral Organs: A Role for the Autonomic Innervation of the Liver

PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
pp. e5650 ◽  
Author(s):  
Cathy Cailotto ◽  
Jun Lei ◽  
Jan van der Vliet ◽  
Caroline van Heijningen ◽  
Corbert G. van Eden ◽  
...  
Keyword(s):  
Gene Expression ◽  
Clock Gene ◽  
Autonomic Innervation ◽  
Peripheral Organs ◽  
Clock Gene Expression

A molecular explanation for the long-term suppression of circadian rhythms by a single light pulse

2001 ◽  
Vol 280 (4) ◽  
pp. R1206-R1212 ◽  
Author(s):  
Jean-Christophe Leloup ◽  
Albert Goldbeter
Keyword(s):  
Gene Expression ◽  
Steady State ◽  
Circadian Rhythms ◽  
Light Pulse ◽  
Molecular Model ◽  
Stable Steady State ◽  
Biochemical Effects ◽  
Actual Duration ◽  
Or Gene

With the use of a molecular model for circadian rhythms in Drosophila based on transcriptional regulation, we show how a single, critical pulse of light can permanently suppress circadian rhythmicity, whereas a second light pulse can restore the abolished rhythm. The phenomena occur via the pulsatile induction of either protein degradation or gene expression in conditions in which a stable steady state coexists with stable circadian oscillations of the limit cycle type. The model indicates that suppression by a light pulse can only be accounted for by assuming that the biochemical effects of such a pulse much outlast its actual duration. We determine the characteristics of critical pulses suppressing the oscillations as a function of the phase at which the rhythm is perturbed. The model predicts how the amplitude and duration of the biochemical changes induced by critical pulses vary with this phase. The results provide a molecular, dynamic explanation for the long-term suppression of circadian rhythms observed in a variety of organisms in response to a single light pulse and for the subsequent restoration of the rhythms by a second light pulse.

Circadian rhythms: from gene expression to behaviour

1992 ◽  
Vol 2 (1) ◽  
pp. 51
Author(s):  
Joseph S Takahashi
Keyword(s):  
Gene Expression ◽  
Circadian Rhythms
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