Plasma therapy for atypical haemolytic uraemic syndrome associated with heterozygous factor H mutations

2011 ◽  
Vol 26 (11) ◽  
pp. 2073-2076 ◽  
Author(s):  
Jon Jin Kim ◽  
Tim H. J. Goodship ◽  
Jane Tizard ◽  
Carol Inward
2021 ◽  
pp. 1753495X2110199
Author(s):  
Mehmet Nuri Duran ◽  
Fatma Beyazit ◽  
Mesut Erbaş ◽  
Onur Özkavak ◽  
Celal Acar ◽  
...  

Pregnancy‐associated atypical haemolytic uraemic syndrome is a rare and potentially lethal complement-mediated disorder. It can mimic preeclampsia, gestational hypertension, thrombotic thrombocytopenic purpura and hemolysis, elevated liver enzymes and low platelets syndrome. Thus, it can be hard to distinguish pregnancy‐associated atypical haemolytic uraemic syndrome from other causes in peri/post-partum women presenting with features of microangiopathic haemolytic anemia, thrombocytopenia and acute kidney injury. We present a case of a 35-year-old woman in her third pregnancy at 32 weeks’ gestation who underwent caesarean section due to fetal distress. She developed severe renal impairment, thrombocytopenia and neurologic symptoms within 24 hours after delivery. A diagnosis of pregnancy‐associated atypical haemolytic uraemic syndrome was provided, and treatment with plasma therapy followed by eculizumab was initiated. A rapid improvement of both clinical and laboratory parameters was observed. This case demonstrates the significance of early initiation of anti-complement therapy to prevent irreversible renal damage and possible death in women with pregnancy‐associated atypical haemolytic uraemic syndrome.


2017 ◽  
Vol 10 (2) ◽  
pp. 263-265
Author(s):  
James Collett ◽  
Amali Mallawaarachchi ◽  
Eddy Fischer ◽  
Muralikrishna Gangadharan Komala ◽  
Kamal Sud ◽  
...  

2008 ◽  
Vol 45 (16) ◽  
pp. 4099
Author(s):  
Viviana Ferreira ◽  
Andrew Herbert ◽  
Claudio Cortes ◽  
Kristi Mckee ◽  
Bärbel Blaum ◽  
...  

2013 ◽  
Vol 68 (1) ◽  
pp. 9-14 ◽  
Author(s):  
A Massart ◽  
S Golmarvi ◽  
S Hachimi-Idrissi ◽  
E Broeders ◽  
Y Tournay ◽  
...  

2018 ◽  
Vol 38 (4) ◽  
pp. 433-437
Author(s):  
John Fredy Nieto-Ríos ◽  
Mónica Zuluaga-Quintero ◽  
Diana Carolina Bello-Márquez ◽  
Arbey Aristizabal-Alzate ◽  
Catalina Ocampo-Kohn ◽  
...  

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii653-iii654
Author(s):  
Elena Román-Ortiz ◽  
Santiago Mendizábal ◽  
Jaouad Anter ◽  
Margarita López-Trascasa ◽  
Pilar Sánchez-Corral ◽  
...  

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