Myeloperoxidase immunohistochemical staining can identify glomerular endothelial cell injury in dense deposit disease

2021 ◽  
Author(s):  
Neal B. Blatt ◽  
Tripti Kumar ◽  
Larysa T. Wickman ◽  
Hassan D. Kanaan ◽  
Anthony Chang ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Immunohistochemical Staining ◽  
Cell Injury ◽  
Dense Deposit Disease ◽  
Glomerular Endothelial Cell ◽  
Endothelial Cell Injury ◽  
Dense Deposit

CD8+iTregs attenuate glomerular endothelial cell injury in lupus-prone mice through blocking the activation of p38 MAPK and NF-κB

2018 ◽  
Vol 103 ◽  
pp. 133-143 ◽  
Author(s):  
Ya Liu ◽  
Weijuan Deng ◽  
Qiaoyun Meng ◽  
Xiaonan Qiu ◽  
Dong Sun ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
P38 Mapk ◽  
Cell Injury ◽  
Glomerular Endothelial Cell ◽  
Endothelial Cell Injury

scholarly journals Reduced Krüppel-Like Factor 2 Aggravates Glomerular Endothelial Cell Injury and Kidney Disease in Mice with Unilateral Nephrectomy

2016 ◽  
Vol 186 (8) ◽  
pp. 2021-2031 ◽  
Author(s):  
Fang Zhong ◽  
Sandeep K. Mallipattu ◽  
Chelsea Estrada ◽  
Madhav Menon ◽  
Fadi Salem ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Kidney Disease ◽  
Cell Injury ◽  
Unilateral Nephrectomy ◽  
Glomerular Endothelial Cell ◽  
Endothelial Cell Injury

The associations of endothelial and podocyte injury in proliferative lupus nephritis: from observational analysis to in vitro study

Lupus ◽  
2019 ◽  
Vol 28 (3) ◽  
pp. 347-358 ◽  
Author(s):  
M Yuan ◽  
Y Tan ◽  
Y Wang ◽  
S X Wang ◽  
F Yu ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Cell Injury ◽  
In Vitro Study ◽  
Glomerular Endothelial Cell ◽  
Endothelial Cell Injury ◽  
Endothelin 1 ◽  
Glomerular Endothelial Cells ◽  
Proliferative Lupus Nephritis

Our study aims to evaluate the endothelial cell-podocyte crosstalk in proliferative lupus nephritis (LN). The semi-quantification scores of glomerular endothelial cell injury and the foot process width (FPW) were processed in 110 proliferative LN patients. Podocytes were stimulated with LN-derived IgG. Glomerular endothelial cells were treated with podocyte-conditioned medium (PCM), and then podocytes were incubated with endothelial cell–conditioned medium (ECM). The levels of vascular endothelial growth factor-A (VEGF-A) in PCM and endothelin-1 in ECM were analyzed, and the injury of podocyte and glomerular endothelial cells were further evaluated. The pathological score of glomerular endothelial cell injury was correlated with FPW in LN complicated with thrombotic microangiopathy. In vitro study showed the following: 1. Stimulation of podocytes by IgG from LN led to decline in the expression of nephrin with cytoskeleton rearrangement, and reduction of VEGF-A levels. 2. Exposure of glomerular endothelial cells to PCM incubated with LN-derived IgG (PCM-LN) induced more endothelin-1 secretion and disruption of intercellular tight junction. 3. Exposure of podocytes to ECM stimulated with PCM-LN could induce cytoskeleton redistribution with decrease of nephrin. In conclusion, the pathological glomerular endothelial cell lesions were associated with FPW and the VEGF-endothelin-1 system might play a critical role in the endothelial cell-podocyte crosstalk in LN.

scholarly journals Involvement of Adhesion Molecules in Glomerular Endothelial Cell Injury Induced by PMA-Stimulated Lymphocytes.

1995 ◽  
Vol 42 (3) ◽  
pp. 361-366 ◽  
Author(s):  
KOSAKU NITTA ◽  
KEIKO UCHIDA ◽  
NAOKO MIWA ◽  
AKIRA KAWASHIMA ◽  
WAKO YUMURA ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Adhesion Molecules ◽  
Cell Injury ◽  
Glomerular Endothelial Cell ◽  
Endothelial Cell Injury
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