T follicular helper cells improve the response of patients with chronic hepatitis B to interferon by promoting HBsAb production

2022 ◽  
Author(s):  
Yong Liu ◽  
Xintong Hu ◽  
Xiaoli Hu ◽  
Lei Yu ◽  
Huifan Ji ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper

scholarly journals Interleukin-7 in Patients With Chronic Hepatitis B May Have Effect on T Follicular Helper Cells and Specific Cellular Immunity

2016 ◽  
Vol 16 (9) ◽  
Author(s):  
Hua Zhong ◽  
Gu Xibing ◽  
Dai Yaping ◽  
Wang Zheng ◽  
Fu Decai ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Cellular Immunity ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Interleukin 7 ◽  
Follicular Helper

T Follicular Helper Cells of the Mother Prevent Vertical Transmission of Hepatitis B to their Babies

2016 ◽  
Vol 64 (2) ◽  
pp. S507 ◽  
Author(s):  
A.K. Vyas ◽  
P. David ◽  
S. Patra ◽  
S.K. Sarin ◽  
N. Trehanpati
Keyword(s):  
Hepatitis B ◽  
Vertical Transmission ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper

Patients with chronic hepatitis C express a high percentage of CD4+CXCR5+ T follicular helper cells

2012 ◽  
Vol 47 (9) ◽  
pp. 1048-1056 ◽  
Author(s):  
Junyan Feng ◽  
Xiaoli Hu ◽  
Hui Guo ◽  
Xiguang Sun ◽  
Juan Wang ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper

scholarly journals T follicular helper cells and antibody response to Hepatitis B virus vaccine in HIV-1 infected children receiving ART

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Yonas Bekele ◽  
Desalegn Yibeltal ◽  
Kidist Bobosha ◽  
Temesgen E. Andargie ◽  
Mahlet Lemma ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Antibody Response ◽  
Virus Vaccine ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper ◽  
B Virus ◽  
Hepatitis B Virus Vaccine ◽  
Hiv 1

Induction of peripheral blood T follicular helper cells expressing ICOS correlates with antibody response to hepatitis B vaccination

2019 ◽  
Vol 92 (1) ◽  
pp. 62-70 ◽  
Author(s):  
Mingluan Xing ◽  
Yonghui Feng ◽  
Jun Yao ◽  
Huakun Lv ◽  
Yongdi Chen ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Antibody Response ◽  
Peripheral Blood ◽  
Hepatitis B Vaccination ◽  
T Follicular Helper Cells ◽  
Helper Cells ◽  
Follicular Helper

scholarly journals Increased Circulating T Follicular Helper Cells Induced via IL-12/21 in Patients With Acute on Chronic Hepatitis B Liver Failure

2021 ◽  
Vol 12 ◽  
Author(s):  
Bingying Du ◽  
Jiaming Teng ◽  
Rongkun Yin ◽  
Yuanyuan Tian ◽  
Tingwang Jiang ◽  
...  
Keyword(s):  
T Cells ◽  
Chronic Hepatitis ◽  
B Cells ◽  
Hepatitis B ◽  
Liver Failure ◽  
Chronic Hepatitis B ◽  
Neutralizing Antibodies ◽  
Cell Subset ◽  
Tfh Cells ◽  
Follicular Helper

ObjectivesT Follicular helper (Tfh) cells, recognized as a distinct CD4+ T cell subset, mediate the development of long-lived humoral immunity via B cell activation/differentiation. Tfh cells play an important role during hepatic viral infection, but its role in hepatitis B virus-related acute on chronic liver failure (HBV-ACLF) remains to be explored.Materials and MethodsThe frequency of Tfh cells, serum pro-inflammatory cytokine (IL-12, IL-21, IL-17 and TNF) levels and IgG/M levels were investigated in HBV-ACLF (n = 36), serious chronic hepatitis B (n = 21), moderate chronic hepatitis B patients (n = 32) and healthy control (HC) subjects (n = 10).ResultsCirculating Tfh cells were significantly increased in HBV-ACLF patients compared to other groups, correlating well with MELD score. However, the frequency of Tfh cells decreased in ameliorated HBV-ACLF patients. Furthermore, serum IL-12 and IL-21 levels were higher in HBV-ACLF patients, compared to other groups. Naïve CD4+ T cells from HC subjects differentiate into Tfh cells following treatment with HBV-ACLF patients’ serum, a process that can be blocked by IL-12/21 neutralizing antibodies. Tfh cells induced by HBV-ACLF patient’s serum promoted the proliferation and IgG production of B cells in vitro. Moreover, circulating CD19+ B cells, serum and liver IgG/M levels were significantly higher in HBV-ACLF patients, compared to other groups.ConclusionsOur data demonstrated that there was a high frequency of Tfh cells and high levels of serum IL-12/21 in HBV-ACLF patients. Naïve CD4+ T cells differentiate into Tfh cells in the presence of HBV-ACLF patients’ serum rich in IL-12/21, which can be blocked by neutralizing IL-12/21 antibodies. These data may provide useful insights for both clinical and basic research in the treatment of HBV-ACLF.

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