Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway

2022 ◽  
Author(s):  
Hidemasa Kawabata ◽  
Yusuke Ono ◽  
Nobue Tamamura ◽  
Kyohei Oyama ◽  
Jun Ueda ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Aggressiveness

scholarly journals Abstract 5801: Loss of core 1 β1,3-galactosyltransferase (C1GALT1) in pancreatic cancer leads to altered mucin glycosylation and increased tumor aggressiveness

2017 ◽  
Author(s):  
Seema Chugh ◽  
Satyanarayana Rachagani ◽  
Xinheng Yu ◽  
Sriram Neelamegham ◽  
Lijun Xia ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Aggressiveness

scholarly journals Tumor innervation and clinical outcome in pancreatic cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Aysha Ferdoushi ◽  
Nathan Griffin ◽  
Mark Marsland ◽  
Xiaoyue Xu ◽  
Sam Faulkner ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Patient Survival ◽  
Tumor Aggressiveness ◽  
Poor Survival ◽  
Cross Sectional ◽  
Neuronal Markers ◽  
Pancreatic Cancers ◽  
S 100 ◽  
Cross Sectional Size ◽  
Clinicopathological Significance

AbstractPancreatic cancer is a highly aggressive malignancy characterized by poor survival, recurrence after surgery and resistance to therapy. Nerves infiltrate the microenvironment of pancreatic cancers and contribute to tumor progression, however the clinicopathological significance of tumor innervation is unclear. In this study, the presence of nerves and their cross-sectional size were quantified by immunohistochemistry for the neuronal markers S-100, PGP9.5 and GAP-43 in a series of 99 pancreatic cancer cases versus 71 normal adjacent pancreatic tissues. A trend was observed between the presence of nerves in the tumor microenvironment of pancreatic cancer and worse overall patient survival (HR = 1.8, 95% CI 0.77–4.28, p = 0.08). The size of nerves, as measured by cross-sectional area, were significantly higher in pancreatic cancer than in the normal adjacent tissue (p = 0.002) and larger nerves were directly associated with worse patient survival (HR = 0.41, 95% CI 0.19–0.87, p = 0.04). In conclusion, this study suggests that the presence and size of nerves within the pancreatic cancer microenvironment are associated with tumor aggressiveness.

Abstract 449: Hypoxia induces tumor aggressiveness by an acquired stem-like phenotype in pancreatic cancer through HIF-1α signaling

2010 ◽  
Author(s):  
Okito Hashimoto ◽  
Syuho Semba ◽  
Kazuya Shimizu ◽  
Ku Yonson ◽  
Hiroshi Yokozaki ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Aggressiveness

Dynamic FDG-PET/CT as an indicator of tumor aggressiveness and patient outcome in pancreatic cancer.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e14526-e14526
Author(s):  
R. Epelbaum ◽  
O. Israel ◽  
R. Haddad ◽  
N. Sikorski ◽  
A. Frenkel
Keyword(s):  
Patient Outcome ◽  
Pancreatic Cancer ◽  
Fdg Pet ◽  
Tumor Aggressiveness ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals An integrated model of N6-methyladenosine regulators to predict tumor aggressiveness and immune evasion in pancreatic cancer

EBioMedicine ◽  
2021 ◽  
Vol 65 ◽  
pp. 103271
Author(s):  
Zhijun Zhou ◽  
Junxia Zhang ◽  
Chao Xu ◽  
Jingxuan Yang ◽  
Yuqing Zhang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Immune Evasion ◽  
Integrated Model ◽  
Tumor Aggressiveness

scholarly journals FOXL1, a Novel Candidate Tumor Suppressor, Inhibits Tumor Aggressiveness and Predicts Outcome in Human Pancreatic Cancer

2013 ◽  
Vol 73 (17) ◽  
pp. 5416-5425 ◽  
Author(s):  
Geng Zhang ◽  
Peijun He ◽  
Jochen Gaedcke ◽  
B. Michael Ghadimi ◽  
Thomas Ried ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Suppressor ◽  
Human Pancreatic Cancer ◽  
Tumor Aggressiveness ◽  
Candidate Tumor Suppressor

Ligand activation of alternatively spliced FGFR-1 modulates pancreatic cancer cell malignancy

2001 ◽  
Vol 120 (5) ◽  
pp. A106-A107
Author(s):  
S VICKERS ◽  
Z HUANG ◽  
L MACMILLANCROW ◽  
J THOMPSON
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Ligand Activation ◽  
Alternatively Spliced ◽  
Cell Malignancy
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