Determination of effective dose combination of Azadirachta indica leaf extracts and diminazene diaceturate in the treatment of experimental Trypanosoma brucei brucei infection in rats

2012 ◽  
Vol 22 (4) ◽  
pp. 747-754
Author(s):  
Valentine U Omoja ◽  
Ikechukwu R. Obidike
Keyword(s):  
Effective Dose ◽  
Trypanosoma Brucei ◽  
Azadirachta Indica ◽  
Trypanosoma Brucei Brucei ◽  
Leaf Extracts ◽  
Dose Combination

Leucocytic profile of rats experimentally infected with Trypanosoma brucei brucei and treated with a combination of methanolic leaf extracts of Azadirachta indica and diminazene diaceturate

2011 ◽  
Vol 21 (6) ◽  
pp. 1463-1471
Author(s):  
Valentine U. Omoja ◽  
Arua O. Anaga ◽  
Reginald I. Obidike ◽  
Thelma E. Ihedioha ◽  
Paschal U. Umeakuana ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Azadirachta Indica ◽  
Trypanosoma Brucei Brucei ◽  
Leaf Extracts

scholarly journals Trypanocidal Potentials of Azadirachta indica: In Vivo Activity of Leaf Extract against Trypanosoma brucei brucei.

1993 ◽  
Vol 15 (2) ◽  
pp. 113-118 ◽  
Author(s):  
Andrew J. NOK ◽  
King A.N. ESIEVO ◽  
Ishaya LONGDET ◽  
Samuel AROWOSAFE ◽  
Paul C. ONYENEKWE ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Azadirachta Indica ◽  
Leaf Extract ◽  
Trypanosoma Brucei Brucei

Effects of aqueous leaf extracts of Loranthus micranthus Linn. on hematological profile of albino rats infected with Trypanosoma brucei brucei

2019 ◽  
Vol 28 (5) ◽  
pp. 1373-1380
Author(s):  
Jude Victor Egbuji ◽  
Vincent Chikwendu Ejere ◽  
Godwin Chigozie Ugwu ◽  
Chinagorom Laureta Okanya
Keyword(s):  
Trypanosoma Brucei ◽  
Albino Rats ◽  
Trypanosoma Brucei Brucei ◽  
Leaf Extracts ◽  
Hematological Profile

scholarly journals Biological and Phytochemical Investigations on Caesalpinia benthamiana, a Plant Traditionally Used as Antimalarial in Guinea

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Jean Loua ◽  
Mohamed Sahar Traore ◽  
Aissata Camara ◽  
Mamadou Aliou Balde ◽  
Louis Maes ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Methanolic Extract ◽  
Moderate Activity ◽  
Good Activity ◽  
Phytochemical Screening ◽  
Antiprotozoal Activity ◽  
Trypanosoma Brucei Brucei ◽  
Leaf Extracts ◽  
Bioassay Guided Fractionation

Caesalpinia benthamiana is widely used as antimalarial in Guinean traditional medicine. Leaf extracts of the plant were tested for their in vitro antiprotozoal activity against Trypanosoma brucei brucei and T. cruzi and the chloroquine-sensitive Ghana strain of Plasmodium falciparum along with their cytotoxicity on MRC-5 cells. The methanolic extract showed the strongest antiprotozoal activity against P. falciparum (IC50 4 μg/ml), a good activity against T. brucei (IC50 13 μg/ml), and a moderate activity against T. cruzi (IC50 31 μg/ml) along with an IC50 on human MRC-5 cells of 32 μg/ml. Bioassay-guided fractionation from the methanolic extract led to antiplasmodially active subfractions. A prospective, placebo-controlled ethnotherapeutic trial assessed the antimalarial effectiveness and tolerability of C. benthamiana syrup administered orally to children with uncomplicated malaria as compared with chloroquine syrup. Phytochemical screening of the leaf extracts indicated the presence of flavonoids, terpenoids, tannins, saponins, and iridoids.

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