Reference Ranges for Prothrombin Time, Activated Partial Thromboplastin Time and Platelet Count in Llamas and Alpacas

2002 ◽  
Vol 11 (4) ◽  
pp. 256-261 ◽  
Author(s):  
N. SUMMERFIELD ◽  
A. N. BAIRD ◽  
R. BOSTON
Keyword(s):  
Platelet Count ◽  
Prothrombin Time ◽  
Partial Thromboplastin Time ◽  
Activated Partial Thromboplastin Time ◽  
Reference Ranges

Can RoTEM®analysis be applied for haemostatic monitoring in paediatric congenital heart surgery?

2011 ◽  
Vol 21 (6) ◽  
pp. 684-691 ◽  
Author(s):  
Jo Bønding Andreasen ◽  
Anne-Mette Hvas ◽  
Kirsten Christiansen ◽  
Hanne Berg Ravn
Keyword(s):  
Cardiac Surgery ◽  
Platelet Count ◽  
Prothrombin Time ◽  
Partial Thromboplastin Time ◽  
Congenital Heart ◽  
Heart Surgery ◽  
Congenital Heart Surgery ◽  
Activated Partial Thromboplastin Time ◽  
Clotting Time ◽  
Coagulation Tests

AbstractBackgroundSuccessful management of bleeding disorders after congenital heart surgery requires detection of specific coagulation disturbances. Whole-blood rotation thromboelastometry (RoTEM®) provides continuous qualitative haemostatic profiles, and the technique has shown promising results in adult cardiac surgery.SettingTo compare the performance of RoTEM®with that of conventional coagulation tests in children, we conducted a descriptive study in children undergoing congenital cardiac surgery. For that purpose, 60 children were enrolled and had blood samples taken before, immediately after, and 1 day after surgery. Conventional coagulation tests included: activated partial thromboplastin time, prothrombin time, fibrinogen, fibrin D-dimer, thrombin clotting time, factor XIII, and platelet count.ResultsPost-surgical haemostatic impairment was present to some degree in all children, as seen by pronounced changes in activated partial thromboplastin time, prothrombin time, thrombin clotting time, and platelet count, as well as RoTEM®analysis. RoTEM®showed marked changes in clotting time – prolonged by 7–18% – clot formation time – prolonged by 46–71% – maximum clot firmness – reduced by 10–19%, and maximum velocity – reduced by 29–39%. Comparison of the two techniques showed that conventional coagulation tests and RoTEM®performed equally well with regard to negative predictive values for excessive post-operative drain production – more than 20 millilitres per kilogram per 24 hours after surgery – with an area under the curve of approximately 0.65.ConclusionRoTEM®can detect haemostatic impairments in children undergoing cardiac surgery and the method should be considered as a supplement in the perioperative care of the children where targeted transfusion therapy is necessary to avoid volume overload.

Evaluation of bone marrow with particular consideration of the megakaryocyte lineage and coagulation profile in the pregnant fallow deer (Dama dama)

2016 ◽  
Vol 19 (2) ◽  
pp. 359-364
Author(s):  
A. Snarska ◽  
P. Sobiech
Keyword(s):  
Bone Marrow ◽  
Platelet Count ◽  
Prothrombin Time ◽  
Partial Thromboplastin Time ◽  
Fallow Deer ◽  
Activated Partial Thromboplastin Time ◽  
Control Group ◽  
Slight Reduction ◽  
Thrombin Time ◽  
Coagulation Parameters

Abstract The aim of the study was to evaluate the megakaryocyte lineage of bone marrow and coagulation parameters in fallow deer during the last month of pregnancy. The animals were managed in the barn-feeding system. Twenty female fallow deer, aged 2-3 years, divided into 2 groups were used in the study. Group 1 comprised the females in the last month of pregnancy, and the non-pregnant females were used as the control. All the animals were clinically healthy. Coagulation parameters were measured in all the deer: thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), and plasma concentrations of fibrinogen, D-dimer, and antithrombin III. A quantitative assessment of bone marrow was carried out for the erythroblastic, myeloid, lymphoid, monocyte-macrophage, and megakaryopoietic cell lines. A detailed analysis of megakaryocyte lineage was performed after whole blood and platelet count. There were no significant differences in the erythroblast, granulocyte, monocyte-macrophage and lymphoid systems between the animal groups. Thrombocyte count in the pregnant deer was lower than that found in the control group. Bone marrow smears revealed a slightly decreased megakaryocyte count, while the megakaryoblast and promegakaryocyte counts were unchanged. The analysis of coagulation parameters showed increased levels of fibrinogen, thrombin time, prothrombin time and activated partial thromboplastin time in the pregnant animals. The study suggested a hyperactivation of the coagulation system with a slight reduction in the megakaryocyte count in bone marrow, and a reduction in platelet count in peripheral blood at the end of pregnancy.

Value of Preoperative Hemostasis Testing in Patients with Liver Disease for Perioperative Hemostatic Management

2017 ◽  
Vol 126 (2) ◽  
pp. 338-344 ◽  
Author(s):  
Ton Lisman ◽  
Robert J. Porte
Keyword(s):  
Platelet Count ◽  
Liver Disease ◽  
Prothrombin Time ◽  
Partial Thromboplastin Time ◽  
Blood Product ◽  
Fibrinogen Level ◽  
Activated Partial Thromboplastin Time

Preoperative hemostasis testing may have limited use in patients with liver disease, and an abnormal platelet count, prothrombin time, activated partial thromboplastin time, and fibrinogen level should not trigger prophylactic transfusion of blood product components.

scholarly journals Effects of Antibiotics on Haemostatic Parameters during Pregnancy

2021 ◽  
pp. 57-62
Author(s):  
Iyevhobu Kenneth Oshiokhayamhe ◽  
Amaechi R. A. ◽  
Turay A. A. ◽  
Okobi T. J. ◽  
Usoro E. R. ◽  
...  
Keyword(s):  
Platelet Count ◽  
Pregnant Women ◽  
Prothrombin Time ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Partial Thromboplastin Time ◽  
Health Centre ◽  
Activated Partial Thromboplastin Time ◽  
Erythrocyte Sedimentation ◽  
Time Test

An estimated 50,000 Nigerian women die each year from complications of pregnancy and childbirth, accounting for 10% of global estimates of pregnancy maternal death with about 2% resulting from drug induction. This cross-sectional study sets out to evaluate the Prothrombin time test (PT), activated partial thromboplastin time test (aPTT) Erythrocyte sedimentation rate (ESR), and Platelet count (PC) of pregnant women attending antenatal clinics at Oredo Health Centre in Benin City, Edo State. A total number of 130 subjects comprising 100 pregnant women and 30 non-pregnant women were recruited for the study. Prothrombin time (PT), Activated Partial Thromboplastin Time (APTT), Platelet count and Erythrocyte Sedimentation Rate (ESR) were studied using standard manual methods. The prothrombin time (sec) of the pregnant women 1st trimester (19.12±0.77b), 2nd trimester (19.90±1.02 b) and 3rd trimester (19.66±0.56 b), activated partial thromboplastin time (sec) 1st trimester (44.02±1.17 b), 2nd trimester (47.72±1.47 b) and 3rd trimester (45.88±1.10b), Erythrocyte sedimentation rate (mm/hr) 1st trimester (24.37±3.04 a), 2nd trimester (37.83±4.53 a) and 3rd trimester (43.25±5.24 a) and platelet count (X109/L) 1st trimester (248.29±23.18a), 2nd trimester (236.33±13.84 b) and 3rd trimester (239.10±16.07 a) were significantly higher than the prothrombin time (sec) 16.48±0.81 a, activated partial thromboplastin time (sec) 36.53±1.42 a, ESR (mm/hr) 29.83±4.14 a and platelet count (X109/L) 201±9.54 an of the non-pregnant women (p<0.05). The ESR (mm/hr) of the 3rd trimester (43.25±5.24) was observed to be significantly higher than that of the 1st trimester (24.37±3.04) and 2nd trimester (37.83±4.53) (p<0.05). Our investigation showed that antibiotics in pregnancy have a deleterious effect on PT, ESR, APTT and PC studied. We recommend that pregnant women should be given due attention throughout the course and events of pregnancy to prevent or reduce the risk of thrombotic episodes and possible disseminated intravascular coagulation (DIC) with resultant better maternity/child safety and health outcome and educated on the effects of antibiotics to pregnancy.

scholarly journals INTRACEREBRAL BLEEDING IN LATE HEMORRHAGIC DISEASE OF THE NEWBORN

2019 ◽  
pp. 1-2
Author(s):  
Jayashree Nadkarni
Keyword(s):  
Platelet Count ◽  
Prothrombin Time ◽  
Vitamin K ◽  
Partial Thromboplastin Time ◽  
Late Onset ◽  
Activated Partial Thromboplastin Time ◽  
The Body ◽  
Hemorrhagic Disease ◽  
Normal Platelet Count ◽  
Normal Platelet

Late onset HDN can present as bleeding from any site of the body but more commonly from intracranial vessels. It is diagnosed if bleeding occurs after 7th day of life with normal platelet count, prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT), associated with stopping of bleeding and PT/PTTreturning to normal after giving vitamin K. Among the types of intracranial bleeding in late hemorrhagic disease of newborn, intracerebral parenchymal bleeding is least common.

scholarly journals Haemostatic Effects of Ethanolic Extracts of Amaranthus hybridus on Wistar Rats

2020 ◽  
pp. 14-21
Author(s):  
B. C. Chinko ◽  
F. S. Amah-Tariah
Keyword(s):  
Platelet Count ◽  
Prothrombin Time ◽  
Partial Thromboplastin Time ◽  
Wistar Rats ◽  
Activated Partial Thromboplastin Time ◽  
Control Group ◽  
Dependent Manner ◽  
Amaranthus Hybridus ◽  
Wide Range ◽  
Ethanolic Extracts

Introduction: Haemostasis refers to the arrest of bleeding due to vascular damage and involves the intrinsic and extrinsic coagulation pathways which converge at the point of fibrin activation to stop or minimize blood loss. Amaranthus hybridus contains a while range of nutritional, chemical and phytochemical constituents which gives it wide range of applications in folk medicine. Aim: To evaluate the effects of ethanolic extracts of Amaranthus hybridus on blood platelet count, prothrombin time (PT) and activated partial thromboplastin time (APTT) using Wistar rat models. Methodology: Twenty Four (24) adult male Wistar rats were used for the study. The animals were randomly divided into three (3) groups of eight (8) animals each. Oral administration of distilled water for the control group and ethanolic extracts of Amaranthus hybridus at 30 and 60 mg/kg lasted for twenty eight (28) days. Platelet count, prothrombin time (PT) and activated partial thromboplastin time (APTT) were determined using standard laboratory methods. Results: Ethanolic extracts of Amaranthus hybridus significantly increased platelet count at 30 mg and 60 mg/kg compared to the control animals (p<0.05). Also, it significantly reduced prothrombin time and activated partial thromboplastin time at 30 and 60 mg/kg in a dose dependent manner compared to control animals (P<0.05).   Conclusion: The study shows that ethanolic extract of Amaranthus hybridus may have enhanced haemostasis as demonstrated by increased platelet count and reduced prothrombin (PT) and activated partial thromboplastin time (APTT) time.

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