scholarly journals Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer’s disease

2012 ◽  
Vol 120 (1) ◽  
pp. 103-111 ◽  
Author(s):  
Lezanne Ooi ◽  
Kuldip Sidhu ◽  
Anne Poljak ◽  
Greg Sutherland ◽  
Michael D. O’Connor ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Drug Discovery ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Disease Modelling ◽  
Induced Pluripotent

Neurons Derived from Induced Pluripotent Stem Cells of Patients with Down Syndrome Reproduce Early Stages of Alzheimer’s Disease Type Pathology in vitro

2017 ◽  
Vol 56 (2) ◽  
pp. 835-847 ◽  
Author(s):  
Erdem B. Dashinimaev ◽  
Alexander S. Artyuhov ◽  
Alexey P. Bolshakov ◽  
Ekaterina A. Vorotelyak ◽  
Andrey V. Vasiliev
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Down Syndrome ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Disease Type ◽  
Early Stages ◽  
Induced Pluripotent

scholarly journals Human Induced Pluripotent Stem Cells and the Modelling of Alzheimer’s Disease: The Human Brain Outside the Dish

2017 ◽  
Vol 11 (1) ◽  
pp. 27-38 ◽  
Author(s):  
Godwin Tong ◽  
Pablo Izquierdo ◽  
Rana Arham Raashid
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Human Brain ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Primary Cultures ◽  
The Elderly ◽  
Global Health Issue ◽  
Induced Pluripotent

Background:Neurodegenerative diseases like Alzheimer’s Disease (AD) are a global health issue primarily in the elderly. Although AD has been investigated using primary cultures, animal models and post-mortem human brain tissues, there are currently no effective treatments.Summary:With the advent of induced pluripotent stem cells (iPSCs) reprogrammed from fully differentiated adult cells such as skin fibroblasts, newer opportunities have arisen to study the pathophysiology of many diseases in more depth. It is envisioned that iPSCs could be used as a powerful tool for neurodegenerative disease modelling and eventually be an unlimited source for cell replacement therapy. This paper provides an overview of; the contribution of iPSCs towards modeling and understanding AD pathogenesis, the novel human/mouse chimeric models in elucidating current AD pathogenesis hypotheses, the possible use of iPSCs in drug screening, and perspectives on possible future directions.Key messages:Human/mouse chimeric models using iPSCs to study AD offer much promise in better replicating AD pathology and can be further exploited to elucidate disease pathogenesis with regards to the neuroinflammation hypothesis of AD.

scholarly journals Elucidating Molecular Phenotypes Caused by the SORL1 Alzheimer’s Disease Genetic Risk Factor Using Human Induced Pluripotent Stem Cells

2015 ◽  
Vol 16 (4) ◽  
pp. 373-385 ◽  
Author(s):  
Jessica E. Young ◽  
Jonathan Boulanger-Weill ◽  
Daniel A. Williams ◽  
Grace Woodruff ◽  
Floyd Buen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Risk Factor ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Genetic Risk ◽  
Genetic Risk Factor ◽  
Induced Pluripotent ◽  
Molecular Phenotypes

scholarly journals Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

Nature ◽  
2012 ◽  
Vol 482 (7384) ◽  
pp. 216-220 ◽  
Author(s):  
Mason A. Israel ◽  
Shauna H. Yuan ◽  
Cedric Bardy ◽  
Sol M. Reyna ◽  
Yangling Mu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Familial Alzheimer’S Disease ◽  
Familial Alzheimer's Disease ◽  
Induced Pluripotent

scholarly journals Modeling familial Alzheimer's disease with induced pluripotent stem cells

2011 ◽  
Vol 20 (23) ◽  
pp. 4530-4539 ◽  
Author(s):  
Takuya Yagi ◽  
Daisuke Ito ◽  
Yohei Okada ◽  
Wado Akamatsu ◽  
Yoshihiro Nihei ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Familial Alzheimer’S Disease ◽  
Familial Alzheimer's Disease ◽  
Induced Pluripotent
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