Levodopa changes brain motor network function during ankle movements in Parkinson’s disease

2012 ◽  
Vol 120 (3) ◽  
pp. 423-433 ◽  
Author(s):  
Petra Schwingenschuh ◽  
Petra Katschnig ◽  
Margit Jehna ◽  
Mariella Koegl-Wallner ◽  
Stephan Seiler ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Network Function ◽  
Motor Network

scholarly journals Co-speech gestures are a window into the effects of Parkinson’s disease on action representations

2020 ◽  
Author(s):  
Stacey Humphries ◽  
JUDITH HOLLER ◽  
Trevor Crawford ◽  
Ellen Poliakoff
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fine Grained ◽  
Network Function ◽  
Person Perspective ◽  
Motor Network ◽  
Third Person ◽  
Third Person Perspective ◽  
Neuropsychological Evidence ◽  
Gesture Production

Parkinson’s disease impairs motor function and cognition, which together affect language and communication. Co-speech gestures are a form of language-related actions that provide imagistic depictions of the speech content they accompany. Gestures rely on visual and motor imagery, but it is unknown whether gesture representations require the involvement of intact neural sensory and motor systems. We tested this hypothesis with a fine-grained analysis of co-speech action gestures in Parkinson’s disease. 37 people with Parkinson’s disease and 33 controls described two scenes featuring actions which varied in their inherent degree of bodily motion. In addition to the perspective of action gestures (gestural viewpoint/first- vs. third-person perspective), we analysed how Parkinson’s patients represent manner (how something/someone moves) and path information (where something/someone moves to) in gesture, depending on the degree of bodily motion involved in the action depicted. We replicated an earlier finding that people with Parkinson’s disease are less likely to gesture about actions from a first-person perspective – preferring instead to depict actions gesturally from a third-person perspective – and show that this effect is modulated by the degree of bodily motion in the actions being depicted. When describing high motion actions, the Parkinson’s group were specifically impaired in depicting manner information in gesture and their use of third-person path-only gestures was significantly increased. Gestures about low motion actions were relatively spared. These results inform our understanding of the neural and cognitive basis of gesture production by providing neuropsychological evidence that action gesture production relies on intact motor network function.

scholarly journals Global efficiency of the motor network is decreased in Parkinson's disease in comparison with essential tremor and healthy controls

2021 ◽  
Author(s):  
Natalia Pelizari Novaes ◽  
Joana Bisol Balardin ◽  
Fabiana Campos Hirata ◽  
Luciano Melo ◽  
Edson Amaro ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Healthy Controls ◽  
Global Efficiency ◽  
Motor Network

Graph theory network function in Parkinson’s disease assessed with electroencephalography

2016 ◽  
Vol 127 (5) ◽  
pp. 2228-2236 ◽  
Author(s):  
Rene L. Utianski ◽  
John N. Caviness ◽  
Elisabeth C.W. van Straaten ◽  
Thomas G. Beach ◽  
Brittany N. Dugger ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Graph Theory ◽  
Network Function

scholarly journals Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson’s disease

2020 ◽  
Author(s):  
Abhinav Sharma ◽  
Diego Vidaurre ◽  
Jan Vesper ◽  
Alfons Schnitzler ◽  
Esther Florin
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Beta Activity ◽  
Beta Band ◽  
Time Resolved ◽  
Functional Roles ◽  
Dopaminergic Medication ◽  
Physiological Processes ◽  
Motor Network ◽  
Theta Frequency

AbstractPathological oscillations including elevated beta activity in the subthalamic nucleus (STN) and between STN and cortical areas are a hallmark of neural activity in Parkinson’s disease (PD). Oscillations also play an important role in normal physiological processes and serve distinct functional roles at different points in time. We characterised the effect of dopaminergic medication on oscillatory whole-brain networks in PD in a time-resolved manner by employing a hidden Markov model on combined STN local field potentials and magnetoencephalography (MEG) recordings from 17 PD patients. Dopaminergic medication led to communication within the medial and orbitofrontal cortex in the delta/theta frequency range. This is in line with deteriorated frontal executive functioning as a side effect of dopamine treatment in Parkinson’s disease. In addition, dopamine caused the beta band activity to switch from an STN-mediated motor network to a frontoparietal-mediated one. In contrast, dopamine did not modify locally-originating STN oscillations in PD. STN–STN synchrony emerged both on and off medication. By providing electrophysiological evidence for the differential effects of dopaminergic medication on the discovered networks, our findings open further avenues for electrical and pharmacological interventions in PD.

Changes of functional connectivity of the motor network in the resting state in Parkinson's disease

2009 ◽  
Vol 460 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Tao Wu ◽  
Liang Wang ◽  
Yi Chen ◽  
Cheng Zhao ◽  
Kuncheng Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Resting State ◽  
Motor Network

scholarly journals Dopaminergic modulation of motor network compensatory mechanisms in Parkinson's disease

2019 ◽  
Vol 40 (15) ◽  
pp. 4397-4416
Author(s):  
Maya A. Jastrzębowska ◽  
Renaud Marquis ◽  
Lester Melie‐García ◽  
Antoine Lutti ◽  
Ferath Kherif ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Compensatory Mechanisms ◽  
Motor Network ◽  
Dopaminergic Modulation

scholarly journals Cerebral blood flow and cerebrovascular reactivity correlate with severity of motor symptoms in Parkinson’s disease

2019 ◽  
Vol 12 ◽  
pp. 175628641983835 ◽  
Author(s):  
Laura Pelizzari ◽  
Maria Marcella Laganà ◽  
Federica Rossetto ◽  
Niels Bergsland ◽  
Mirco Galli ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Rating Scale ◽  
Neurovascular Unit ◽  
Cerebrovascular Reactivity ◽  
Motor Symptoms ◽  
Precentral Gyrus ◽  
Motor Network

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder that is mainly characterized by movement dysfunction. Neurovascular unit (NVU) disruption has been proposed to be involved in the disease, but its role in PD neurodegenerative mechanisms is still unclear. The aim of this study was to investigate cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) within the regions belonging to the motor network, in patients with mild to moderate stages of PD. Methods: Twenty-eight PD patients (66.6 ± 8.6 years, 22 males, median [interquartile range, IQR] Hoehn & Yahr = 1.5 [1–1.9]) and 32 age- and sex-matched healthy controls (HCs) were scanned with arterial spin labeling (ASL) magnetic resonance imaging (MRI) for CBF assessment. ASL MRI was also acquired in hypercapnic conditions to induce vasodilation and subsequently allow for CVR measurement in a subgroup of 13 PD patients and 13 HCs. Median CBF and CVR were extracted from cortical and subcortical regions belonging to the motor network and compared between PD patients and HCs. In addition, the correlation between these parameters and the severity of PD motor symptoms [quantified with Unified Parkinson’s Disease Rating Scale part III (UPDRS III)] was assessed. The false discovery rate (FDR) method was used to correct for multiple comparisons. Results: No significant differences in terms of CBF and CVR were found between PD patients and HCs. Positive significant correlations were observed between CBF and UPDRS III within the precentral gyrus, postcentral gyrus, supplementary motor area, striatum, pallidum, thalamus, red nucleus, and substantia nigra (pFDR < 0.05). Conversely, significant negative correlation between CVR and UPDRS III was found in the corpus striatum (pFDR < 0.05). Conclusion: CBF and CVR assessment provides information about NVU integrity in an indirect and noninvasive way. Our findings support the hypothesis of NVU involvement at the mild to moderate stages of PD, suggesting that CBF and CVR within the motor network might be used as either diagnostic or prognostic markers for PD.

scholarly journals Pallidal Thermolesion Unleashes Gamma Oscillations in the Motor Cortex in Parkinson's Disease

Neurosurgery ◽  
2019 ◽  
Vol 66 (Supplement_1) ◽  
Author(s):  
Doris D Wang ◽  
Coralie de Hemptinne ◽  
Svjetlana Miocinovic ◽  
Witney Chen ◽  
Jill L Ostrem ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Essential Tremor ◽  
Primary Motor Cortex ◽  
Gamma Oscillations ◽  
Gamma Band ◽  
Motor Dysfunction ◽  
Oscillatory Activity ◽  
Motor Network

Abstract INTRODUCTION In Parkinson's disease, the emergence of motor dysfunction is thought to be related to an imbalance between antikinetic and prokinetic patterns of oscillatory activity in the motor network. Invasive recordings from the basal ganglia and cortex in surgical patients have suggested that levodopa and therapeutic deep brain stimulation can suppress antikinetic beta band (13-30 Hz) rhythms while promoting prokinetic gamma band (60-90 Hz) rhythms. Surgical ablation of the globus pallidus internus is one of the oldest effective therapies for Parkinson's disease and gives a remarkable immediate relief from rigidity and bradykinesia, but its effects on oscillatory activity in the motor network have not been studied. We characterize the effects of pallidotomy on cortical oscillatory activity in Parkinson's disease patients. METHODS Using a temporary 6-contact lead placed over the sensorimotor cortex in the subdural space, we recorded acute changes in cortical oscillatory activities in 3 Parkinson's disease patients undergoing pallidotomy and compared the results to that of 3 essential tremor patients undergoing thalamotomy. RESULTS In all 3 Parkinson's disease patients, we observed the emergence of an approximately 70 to 80 Hz narrow-band oscillation with effective thermolesion of the pallidum. This gamma oscillatory activity was spatially localized over the primary motor cortex, was minimally affected by voluntary movements, and was not found in the motor cortex of essential tremor patients undergoing thalamotomy. CONCLUSION Our finding suggests that acute lesioning of the pallidum promotes cortical gamma band oscillations. This may represent an important mechanism for alleviating bradykinesia in Parkinson's disease.

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