Decreased levels of repulsive guidance molecule A in association with beneficial effects of repeated intrathecal triamcinolone acetonide application in progressive multiple sclerosis patients

2014 ◽  
Vol 122 (6) ◽  
pp. 841-848 ◽  
Author(s):  
Thomas Müller ◽  
Stefan Barghorn ◽  
Sven Lütge ◽  
Thomas Haas ◽  
Reinhold Mueller ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Triamcinolone Acetonide ◽  
Progressive Multiple Sclerosis ◽  
Beneficial Effects ◽  
Repulsive Guidance Molecule ◽  
Repulsive Guidance Molecule A ◽  
Multiple Sclerosis Patients ◽  
Guidance Molecule

scholarly journals Air bubble after intrathecal triamcinolone acetonide application in a progressive multiple sclerosis patient

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Thomas Müller ◽  
◽  
Sven Lütge; Gunnar Gäde ◽  
Keyword(s):  
Multiple Sclerosis ◽  
Triamcinolone Acetonide ◽  
Fold Increase ◽  
Progressive Multiple Sclerosis ◽  
Walking Distance ◽  
Air Bubble ◽  
Upper Limb Function ◽  
Repulsive Guidance Molecule ◽  
Repulsive Guidance Molecule A ◽  
Guidance Molecule

Repeated intrathecal application of the sustained release steroid Triamcinolone Acetonide (TCA) is beneficial in progressive Multiple Sclerosis (MS) patients [1]. Particularly, patients with spinal lesions often show a distinct benefit with a three fold increase of the maximum walking distance [2]. This therapy ameliorates walking distance, improves upper limb function and reduces spastic symptoms [1]. The putative regenerative effect may result from declined synthesis of the repulsive guidance molecule A [3]. Visualization of air bubbles after a TCA injection prompted this case report.

Efficacy and safety of repeated intrathecal triamcinolone acetonide application in progressive multiple sclerosis patients

2003 ◽  
Vol 211 (1-2) ◽  
pp. 81-84 ◽  
Author(s):  
Volker Hoffmann ◽  
Sebastian Schimrigk ◽  
Saida Islamova ◽  
Kerstin Hellwig ◽  
Carsten Lukas ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Triamcinolone Acetonide ◽  
Progressive Multiple Sclerosis ◽  
Efficacy And Safety ◽  
Multiple Sclerosis Patients

scholarly journals Targeting Repulsive Guidance Molecule A to Promote Regeneration and Neuroprotection in Multiple Sclerosis

Cell Reports ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. 1887-1898 ◽  
Author(s):  
Elena Demicheva ◽  
Yi-Fang Cui ◽  
Philip Bardwell ◽  
Stefan Barghorn ◽  
Martina Kron ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Repulsive Guidance Molecule ◽  
Repulsive Guidance Molecule A ◽  
Guidance Molecule
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