Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials

2011 ◽  
Vol 30 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Yanfu Fang ◽  
Chuanlai Hu ◽  
Xingyong Tao ◽  
Yuhui Wan ◽  
Fangbiao Tao
Keyword(s):  
Bone Mineral Density ◽  
Randomized Controlled Trials ◽  
Bone Mineral ◽  
Vitamin K ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Mineral Density ◽  
Randomized Controlled

scholarly journals The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled trials

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Liyou Hu ◽  
Jindou Ji ◽  
Dong Li ◽  
Jing Meng ◽  
Bo Yu
Keyword(s):  
Bone Mineral Density ◽  
Randomized Controlled Trials ◽  
Bone Mineral ◽  
Vitamin K ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Combined Effect ◽  
Controlled Trials ◽  
Mineral Density ◽  
Randomized Controlled

Abstract Background With the increasing incidence of osteoporosis, vitamin K and calcium have been linked to bone mineral density (BMD) and undercarboxylated osteocalcin (UcOC) in many studies, but the results of studies of the combined effect of vitamin K and calcium on BMD and UcOC in humans have been inconsistent. We conducted a systematic review of randomized controlled trials to assess the effect of this combination treatment on BMD and UcOC in humans. Methods A search for articles was conducted using PubMed, Embase, and the Cochrane Library database up to March 2021 (no language restrictions). We also reviewed the reference lists of the relevant publications and reviews to locate additional publications. The standard mean difference (SMD) was used as the primary measure of effect size. Our main endpoints were lumbar BMD, femoral neck BMD, hip BMD, total femoral BMD, and UcOC from baseline to end point. We performed subgroup analysis, heterogeneity testing, and assessment of publication bias. Results A total of 1346 patients from 10 randomized controlled trials were included in the meta-analysis. The forest plot analysis revealed that vitamin K combined with calcium was associated with a higher lumbar spine BMD compared to controls. The SMD was 0.20 [95% confidence interval (CI): 0.07 to 0.32]. Vitamin K and calcium supplementation led to a significant decrease in UcOC (SMD: − 1.71, 95% CI: − 2.45 to − 0.96). Subgroup analysis showed that vitamin K2 and vitamin K1 had SMDs of 0.30 (95% CI: 0.10 to 0.51) and SMDs of 0.14 (95% CI: − 0.02 to 0.29), and calcium dosages of ≤ 1000 mg/d or > 1000 mg/d had SMDs of 0.19 (95% CI: 0.05 to 0.32) and 0.26 (95% CI: − 0.04 to 0.55). Conclusion The combination of vitamin K and calcium has a positive effect on lumbar BMD and decreases the level of UcOC. Registration: The protocol for this meta-analysis was registered at the International Prospective Register of Systematic Reviews (CRD42021251825).

scholarly journals Exercise and Bone Mineral Density in Premenopausal Women: A Meta-Analysis of Randomized Controlled Trials

2013 ◽  
Vol 2013 ◽  
pp. 1-16 ◽  
Author(s):  
George A. Kelley ◽  
Kristi S. Kelley ◽  
Wendy M. Kohrt
Keyword(s):  
Bone Mineral Density ◽  
Randomized Controlled Trials ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Premenopausal Women ◽  
The United States ◽  
Controlled Trials ◽  
Number Needed To Treat ◽  
Mineral Density ◽  
Randomized Controlled

Objective. Examine the effects of exercise on femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) in premenopausal women.Methods. Meta-analysis of randomized controlled exercise trials ≥24 weeks in premenopausal women. Standardized effect sizes (g) were calculated for each result and pooled using random-effects models,Zscore alpha values, 95% confidence intervals (CIs), and number needed to treat (NNT). Heterogeneity was examined usingQandI2. Moderator and predictor analyses using mixed-effects ANOVA and simple metaregression were conducted. Statistical significance was set atP≤0.05.Results. Statistically significant improvements were found for both FN (7g's, 466 participants,g=0.342, 95%  CI=0.132, 0.553,P=0.001,Q=10.8,P=0.22,I2=25.7%,NNT=5) and LS (6g's, 402 participants,g=0.201, 95%  CI=0.009, 0.394,P=0.04,Q=3.3,P=0.65,I2=0%,NNT=9) BMD. A trend for greater benefits in FN BMD was observed for studies published in countries other than the United States and for those who participated in home versus facility-based exercise. Statistically significant, or a trend for statistically significant, associations were observed for 7 different moderators and predictors, 6 for FN BMD and 1 for LS BMD.Conclusions. Exercise benefits FN and LS BMD in premenopausal women. The observed moderators and predictors deserve further investigation in well-designed randomized controlled trials.

Sign in / Sign up

Export Citation Format

Share Document