Venous thromboembolism associated with lower limb fractures after trauma: dilemma and management

2015 ◽  
Vol 20 (2) ◽  
pp. 364-372 ◽  
Author(s):  
Chia-Chi Chu ◽  
Hirofumi Haga
2016 ◽  
Vol 18 (3) ◽  
pp. 263-268 ◽  
Author(s):  
Sanil H. Ajwani ◽  
Alex Shaw ◽  
Osamah Naiz ◽  
Deepu Bhaskar ◽  
Charalambos P. Charalambous

2016 ◽  
Vol 23 (1) ◽  
pp. 78-83 ◽  
Author(s):  
Yong Yang ◽  
Pengfei Zan ◽  
Jinpeng Gong ◽  
Ming Cai

Objective: For the present study, the authors hypothesized that the d-dimer levels would be systematically raised in a postoperative population of patients younger than 50 with lower limb fractures and to define a feasible cutoff value for identification of venous thromboembolism (VTE). Methods: Doppler ultrasonography of lower limbs was performed pre- and postoperatively to evaluate for deep vein thrombosis in 150 patients who underwent open reduction and internal fixation (ORIF). Plasma d-dimer levels were assessed 2 days before surgery and on the 3rd, 7th, and 10th days after surgery. Statistical analysis was carried out to define a feasible threshold for the d-dimer levels. Results: Plasma d-dimer levels were found to be systematically raised postoperatively, and they differed between patients with and without VTE significantly. On the third day after surgery, d-dimer levels of more than 3 mg/L indicated VTE with a sensitivity of 88.37% and a specificity of 96.96%, allowing for the definition of a feasible cutoff value. Duration of surgery, duration of tourniquet, ventilation time, and time of postoperative immobility of lower limbs were identified as highly significant risk factors for the development of VTE. Conclusion: Using a threshold of 3 mg/L, the d-dimer levels will screen out VTE with a high degree of sensitivity and specificity in younger patients who have undergone ORIF for lower limb fractures.


2021 ◽  
Author(s):  
Ylenia Colella ◽  
Arianna Scala ◽  
Chiara De Lauri ◽  
Francesco Bruno ◽  
Giuseppe Cesarelli ◽  
...  

Author(s):  
J. Mingo-Robinet ◽  
J.A. Alonso ◽  
M. Moreno-Barrero ◽  
L. González-García ◽  
V. Garcia-Virto ◽  
...  

2000 ◽  
Vol 35 (6) ◽  
pp. 851
Author(s):  
Tae Woo Park ◽  
Sung Do Cho ◽  
Yong Sun Cho ◽  
Bum Soo Kim ◽  
Soon Woo Hong ◽  
...  

2004 ◽  
Vol 92 (11) ◽  
pp. 1166-1167 ◽  
Author(s):  
Francesco Dentali ◽  
Davide Imberti ◽  
Walter Ageno

2019 ◽  
Vol 10 (6) ◽  
pp. 715-719
Author(s):  
Lars Ung ◽  
Malte Ohlmeier ◽  
Birger Jettkant ◽  
Dennis Grasmücke ◽  
Mirko Aach ◽  
...  

Study Design: Retrospective observational study. Objectives: To analyze the clinical and radiological outcomes of lower limb fractures following surgical treatment in patients with chronic spinal cord injury (SCI). Methods: Between January 2003 and December 2015, 102 chronic SCI patients with a lower limb fracture were surgically treated at our hospital. A total of 58 patients met the inclusion criteria and were recruited for final analysis. Patients with 2-stage procedure or incomplete clinical records with lost-to-follow-up were excluded from the study. Patients were divided into 2 groups (group 1= internal fixation; group 2 = external fixation). Primary outcome measures were to identify the number of nonunions via Kaplan-Meier analysis and the time to bone consolidation. The diagnosis of a pseudarthrosis was made after more than 180 days of consolidation time. Considering the Kaplan-Meier analysis, pseudarthrosis was interpreted as treatment failure. Secondary outcome measure was to evaluate the complication rate with special focus on heterotopic ossification. Results: A total of 58 chronic SCI patients with closed bone fractures were included in this study. Fifty-two fractures (88%) were simple and 7 (12%) were complex (type C) fractures according to AO classification. The majority of patients (34 cases, 59%) developed femur fractures followed by 24 tibial fractures (41%). Seventeen patients received an external (29%) and 41 an internal fixation (71%). Bone consolidation was reported in 31 patients (53%) with a mean time interval of bone consolidation after 97 days (range from 45 to 160 days; SD = 30). The reported nonunion (pseudarthrosis) rate was 47%. Comparing the internal group (n = 15 patients) versus the external group (n = 14), we could not find any significant difference ( P = .939) concerning the bone consolidation time. The Kaplan-Meier analysis showed a 75% cumulative survivorship at 120 days (internal group) versus 111 days (external group). Most common postoperative complications occurred in the internal fixation group with Wound infections being predominantly observed (10%), followed by heterotopic ossifications (8%). Conclusions: Our results show that surgical treatment of lower limb fractures in chronic SCI patients is a challenging treatment with a high pseudarthrosis rate in both groups. The complication rate seems to be lower in the patients treated with external fixation. As a clinical recommendation, longer implants should be used for a stable osteosynthesis since SCI patients seem to have a higher load on the osteosynthesis material due to missing sensomotoric feedback.


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