Elevated interleukin-12 in pseudosynovial fluid in patients with aseptic loosening of hip prosthesis

2000 ◽  
Vol 5 (4) ◽  
pp. 369-373 ◽  
Author(s):  
Masayoshi Inomoto ◽  
Syunpei Miyakawa ◽  
Hajime Mishima ◽  
Naoyuki Ochiai
Keyword(s):  
Aseptic Loosening ◽  
Hip Prosthesis ◽  
Interleukin 12 ◽  
Loosening Of Hip Prosthesis

Serum Interleukin 8 Levels Correlate With Synovial Fluid Levels in Patients With Aseptic Loosening of Hip Prosthesis

2005 ◽  
Vol 20 (8) ◽  
pp. 1049-1054 ◽  
Author(s):  
Ryuji Tanaka ◽  
Yugi Yasunaga ◽  
Takashi Hisatome ◽  
Takuma Yamasaki ◽  
Hiroshi Iwamori ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Aseptic Loosening ◽  
Hip Prosthesis ◽  
Interleukin 8 ◽  
Loosening Of Hip Prosthesis ◽  
Fluid Levels

Analysis of 18F-FDG uptake patterns in PET for diagnosis of septic and aseptic loosening after total hip arthroplasty

2003 ◽  
Vol 42 (06) ◽  
pp. 234-239 ◽  
Author(s):  
T. Mumme ◽  
P. Reinartz ◽  
D. Wirtz ◽  
F. U. Niethard ◽  
U. Büll ◽  
...  
Keyword(s):  
Aseptic Loosening ◽  
Femoral Component ◽  
Hip Prosthesis ◽  
Prosthetic Infection ◽  
Clinical Value ◽  
Septic Loosening ◽  
Hip Prostheses ◽  
Fdg Uptake ◽  
Positron Emission ◽  
Painful Hip

Summary Aim: Identification of typical patterns for fluorodeoxyglucose (FDG) uptake in positron emission tomography (PET) to detect aseptic loosening of hip prosthesis (ace-tabular and/or femoral component) and prosthetic infection. Methods: 18 patients with painful hip prosthesis underwent PET using a dedicated full ring scanner after application of 200-300 MBq FDG. The interface between bone and surrounding soft tissue or bone as displayed on coronal slices was divided into 12 segments in accordance with the classifications of Delee and Gruen. FDG uptake in each of the segments was scored (0-3) by two independent observers. Intraoperative findings were regarded as the gold standard. Results: After surgical revision 14 acetabular components and 9 femoral components were found to be loose and prosthetic infection was present in 7 prostheses. Loosening of the acetabular component was correlated to enhanced uptake in the middle of the acetabular interface, while loosening of the femoral component was correlated to enhanced uptake in the proximal and middle segment of the lateral femoral interface and the proximal segment of the medial femoral interface. A similar pattern was found in prosthetic infection with high uptake along the middle portion of the lateral fe-moral interface. In 6 of 7 infected prostheses loosening of the acetabular and of the femoral component was present. Taking the typical uptake patterns as criteria for loosening and grade 3 uptake as an additional criterion for septic loosening the accuracy of PET imaging in the detection of loosening of the acetabular or the femoral component and of prosthetic infection was 72, 78 and 89%, respectively. Conclusion: This pilot study presents FDG-PET as a promising diagnostic tool for patients with painful hip prostheses. Its clinical value should be evaluated in a larger patient population.

scholarly journals Review of the role of dynamic 18F-NaF PET in diagnosing and distinguishing between septic and aseptic loosening in hip prosthesis

2015 ◽  
Vol 10 (1) ◽  
pp. 5 ◽  
Author(s):  
Olu Adesanya ◽  
Andrew Sprowson ◽  
James Masters ◽  
Charles Hutchinson
Keyword(s):  
Aseptic Loosening ◽  
Hip Prosthesis

scholarly journals A Method for Prediction of Femoral Component of Hip Prosthesis Durability due to Aseptic Loosening by Using Coffin/Manson Fatigue Model

2018 ◽  
Vol 2018 ◽  
pp. 1-13
Author(s):  
Branislav Krivokapic ◽  
Zoran Blagojevic ◽  
Dora Selesi ◽  
Teodor Atanackovic ◽  
Stevan Pilipovic ◽  
...  
Keyword(s):  
Fatigue Life ◽  
Aseptic Loosening ◽  
Hip Prosthesis ◽  
Real Life ◽  
Physical Activities ◽  
Femoral Offset ◽  
Model Estimate ◽  
Daily Physical Activities ◽  
High Degree ◽  
Prosthesis Durability

The purpose of this work is to develop a new model estimate of the fatigue life of a hip prosthesis due to aseptic loosening as a multifactorial phenomenon. The formula developed here is a three-parameter model based on Basquin’s law for fatigue, eccentric compression formula for the compressive stress and torsion in the prosthesis due to the horizontal components of the contact force. With our model, we can accurately predict the durability of a hip prosthesis due to the following four parameters: body weight, femoral offset, duration, and intensity of daily physical activities of a patient. The agreement of the prediction with the real life of the prosthesis, observed on 15 patients, is found to be adequate. Based on the formula derived for a particular implant, there was a high degree of concurrence between the model-predicted and actual values of aseptic loosening (durability) proved by the Mann–Whitney U test. By virtue of the validated model, it is possible to predict, quantitatively, the influence of various factors on the hip life. For example, we can conclude that a 10% decrease of a patient’s body mass, with all other conditions being the same, causes 5% increase of the hip fatigue life.

scholarly journals Enzymes and cytokines disease in total hip arthroplasty: promoters of immune loosening

2018 ◽  
Vol 66 (3) ◽  
pp. 477-484
Author(s):  
Victorino Pacheco-Martelo ◽  
Sebastián Roldán-Vasco
Keyword(s):  
Total Hip Arthroplasty ◽  
Aseptic Loosening ◽  
Hip Arthroplasty ◽  
Hip Prosthesis ◽  
Prosthesis Loosening ◽  
Total Hip ◽  
Hip Prosthesis Loosening ◽  
Arthroplasty Failure

Introducción. Una de las causas más importantes de falla de la prótesis de cadera lo constituye el fenómeno de aflojamiento, el cual se relaciona con la liberación de enzimas mediada por citocinas y produce la lisis del hueso que soporta el implante.Objetivo. Describir los mecanismos de interacción biológica de las moléculas promotoras del aflojamiento de la prótesis total de cadera que con mayor frecuencia están presentes en el proceso.Materiales y métodos. Se realizó una búsqueda de artículos originales y casos clínicos en las bases de datos PubMed y Scopus, sin límite de fecha de publicación, utilizando los términos MeSH “hip prosthesis loosening”, “aseptic loosening”, “cytokines” y “hip arthroplasty failure”. La extracción de datos se hizo mediante la lectura de 250 estudios, de los cuales se seleccionaron 66 para fines de redacción.Resultados. Los autores describen las moléculas más representativas implicadas en el aflojamiento de la prótesis de cadera, además se presentan las interacciones entre ellas.Conclusiones. Enzimas y citocinas han sido ampliamente estudiadas por cuatro décadas, aunque sus mecanismos de interacción son poco conocidos. Los autores proponen un mecanismo de interacción, proceso que podría denominarse “enfermedad de las enzimas y citocinas” o “aflojamiento inmunológico”.

Characterization of wear debris associated with aseptic loosening of a canine hip prosthesis

1998 ◽  
Vol 119 (1) ◽  
pp. 89-93 ◽  
Author(s):  
M.J. Day ◽  
S.J. Butterworth ◽  
M.R. Palmer ◽  
C.P. Case
Keyword(s):  
Aseptic Loosening ◽  
Wear Debris ◽  
Hip Prosthesis

3rd Generation Alumina-on-Alumina in Modular Hip Prosthesis: 13 to 18 Years Follow-up Results

2016 ◽  
Vol 27 (1) ◽  
pp. 8-13 ◽  
Author(s):  
Aldo Toni ◽  
Federico Giardina ◽  
Giovanni Guerra ◽  
Alessandra Sudanese ◽  
Maurizio Montalti ◽  
...  
Keyword(s):  
Aseptic Loosening ◽  
Hip Prosthesis ◽  
Septic Loosening ◽  
Early Experiences ◽  
Clinical And Radiological Outcome ◽  
The Mean ◽  
Modular Hip Prosthesis ◽  
Ceramic On Ceramic

Introduction Ceramic-on-ceramic (CoC) couplings are alternative bearings surfaces that have been reported to reduce osteolysis, wear debris and aseptic loosening compared to the use of polyethylene. Early experiences with ceramics had poor results, but they have led to many improvements in the manufacture and design of subsequent implants. Methods We analysed medical files of 300 CoC total hip arthroplasty (THA) with a modular neck performed during period 1995-2000 by a single surgeon for a minimum follow-up of 13 years, evaluating clinical and radiological outcome. Results The mean clinical Merle d'Aubigne and Postel hip score at the final follow-up is 17.4, against a pre-operative value of 11.4. Overall survivorship with an endpoint of revision is 93.2% (95% CI, 89.0%-97.3%) at 15 years, while considering only prosthesis failures related to aseptic loosening and ceramic breakage, survival rate at 15 years is 97.2% (95% CI, 94.8%-100%). We observed complications that led to revision surgery in 11 patients (4%) (periprosthetic fractures, liner ruptures, septic loosening of the implant, aseptic loosening of the cup, aseptic loosening of the stem). The occurrence of squeaking is low (1.6%, 4 cases) and we analysed the characteristics of these patients. Discussion Our study shows an excellent long term survivorship of third generation alumina CoC THA. We reiterate the importance to have a stable implant to maximise the advantage of ceramic and to avoid complications.

Outcome and complications after dual mobility total hip replacement

2012 ◽  
Vol 25 (06) ◽  
pp. 511-517 ◽  
Author(s):  
A. Autefage ◽  
T. Dembour ◽  
J.-L. Chancrin ◽  
P. Guillaumot
Keyword(s):  
Aseptic Loosening ◽  
Acetabular Component ◽  
Acetabular Fracture ◽  
Hip Prosthesis ◽  
Perioperative Complications ◽  
Greater Trochanter ◽  
Dual Mobility ◽  
Total Hip ◽  
Trochanter Fracture

SummaryObjectives: To report the clinical and radiographic outcome of a canine total hip prosthesis with a dual mobility acetabular component, with a minimum of six months follow-up.Methods: The outcome of dogs that underwent primary cemented unilateral dual mobility hip prosthesis surgery by one of the authors for hip dysplasia or trauma, and which had a minimum of six months clinical and radiologic follow-up, was evaluated.Results: Fifty dogs were included in the study. Follow-up ranged from six to 38 months (mean 14.4 months). Perioperative complications were acetabular collapse (n = 1) and greater trochanter fracture (n = 1), both of which were successfully managed perioperatively. Postoperative complications were aseptic loosening of the acetabular component (n = 2; both surgically revised), implant sepsis (n = 3; all explanted), acetabular fracture (n = 1; conservatively managed), greater trochanter fracture (n = 1; conservatively managed) and sciatic neurapraxia (n = 1). No cases of postoperative luxation or femoral implant aseptic loosening were encountered. Outcome was poor for three cases (3 implant sepsis), fair for three cases (including 1 acetabular component loosening and 1 acetabular fracture), and good or excellent for 44 cases (88%).Clinical significance: There were not any cases of postoperative coxofemoral luxation observed in this series of 50 dogs with dual mobility hip prosthesis. Studies with more patients and longer follow-up are needed to confirm the satisfactory results observed to date with this implant.

Aseptic Loosening of the Monk hip Prosthesis

1980 ◽  
Vol 51 (1-6) ◽  
pp. 833-839 ◽  
Author(s):  
Niels Mossing ◽  
Jes Erin-Madsen
Keyword(s):  
Aseptic Loosening ◽  
Hip Prosthesis
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