A longitudinal three-center study of craniofacial morphology at 6 and 12 years of age in patients with complete bilateral cleft lip and palate

Objective To evaluate the possible association between the size of the premaxilla in infants and craniofacial morphology in children with complete bilateral cleft lip and palate (CBCLP) and identify the characteristics of craniofacial morphology in children with CBCLP with median facial dysplasia (MFD). Design Retrospective study. Setting A university hospital craniofacial center. Subjects Thirty-four patients with nonsyndromic CBCLP, 24 boys and 10 girls, had large premaxilla (LP group). Thirty-six patients with nonsyndromic CBCLP, 16 boys and 20 girls, had small premaxilla (SP group). Thirteen CBCLP patients with MFD, five boys and eight girls (MFD group). Main Outcome Measures Infant maxillary dental cast at the age of 1 year was used to measure the size of the premaxilla. Cephalometric analysis was used to determine craniofacial morphology in children at the age of 5 years. Results The size of the premaxilla in infants with CBCLP varied greatly. The LP group tended to have a longer maxilla and a more protruded maxilla, producing a better interjaw relation. The opposite phenomena were observed in the MFD group; the SP group yielded results between those of the LP and the MFD groups. Conclusion The size of the premaxilla in infants with CBCLP can be used to predetermine subsequent craniofacial morphology at the age of 5 years. Children with nonsyndromic CBCLP had craniofacial characteristics that differed significantly from those of children with CBCLP with median facial dysplasia.

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A Longitudinal Three-Center Study of Dental Arch Relationship in Patients With Bilateral Cleft Lip and Palate

The Cleft Palate-Craniofacial Journal ◽

10.1597/08-249.1 ◽

2010 ◽

Vol 47 (2) ◽

pp. 167-174 ◽

Cited By ~ 13

Author(s):

Theodosia Bartzela ◽

Christos Katsaros ◽

William C. Shaw ◽

Elisabeth Rønning ◽

Sara Rizell ◽

...

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Dental Arch ◽

Bilateral Cleft Lip ◽

Dental Arch Relationship ◽

Center Study

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Three-Dimensional Analysis of the Pharyngeal Airway Volume and Craniofacial Morphology in Patients With Bilateral Cleft Lip and Palate

The Cleft Palate-Craniofacial Journal ◽

10.1177/1055665620946982 ◽

2020 ◽

pp. 105566562094698

Author(s):

Wenying Kuang ◽

Jie Zheng ◽

Shaolin Li ◽

Shiyu Yuan ◽

Hong He ◽

...

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Three Dimensional ◽

Tertiary Hospital ◽

Craniofacial Morphology ◽

Class I ◽

Oropharyngeal Airway ◽

Pharyngeal Airway ◽

Bilateral Cleft Lip ◽

Maxilla And Mandible

Objective: This study aimed to determine the correlations between the craniofacial morphology and pharyngeal airway volume in patients with complete bilateral cleft lip and palate (BCLP). Design: Retrospective study. Setting: Tertiary hospital. Participants: Twenty-seven patients with complete BCLP and 27 class I control patients, aged 10 to 14 years. Main Outcome Measure: The pharyngeal airway volume and craniofacial morphology were evaluated using cone-beam computed tomography. Measurements were compared between groups and any correlations were identified. Results: A significantly smaller total pharyngeal airway volume (TPV), oropharyngeal airway volume, and upper (UOPV) and lower (LOPV) oropharyngeal airway volume were found in patients with BCLP than in class I control patients, with no difference in the nasopharyngeal volume between groups. Furthermore, the craniofacial morphology measurements of N-Me, S-Go, Or-C, Ptm-C, Me-C, Co-Go, Go-Me, Ptm-Or, N-S-Ar, and Ar-Go-Me significantly differed between the BCLP and control groups (all P < .05). Multiple regression analysis indicated that Ptm-C and Me-C; Ptm-C, Or-C, and Me-C; and Me-C explained 20.3%, 38.9%, and 17.1% of the variations in TPV ( P = .025), UOPV ( P = .002), and LOPV ( P = .018), respectively. Conclusions: Total pharyngeal airway volume, TPV, OPV, UOPV, and LOPV were significantly smaller in patients with BCLP than in class I controls. In patients with BCLP, the maxilla showed inhibited sagittal development and a retrograde position; moreover, the pharyngeal airway volume was weakly associated with the position of the maxilla and mandible relative to the coronal plane.

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Craniofacial Morphology in Adult Patients with Unoperated Complete Bilateral Cleft Lip and Palate

The Cleft Palate-Craniofacial Journal ◽

10.1597/1545-1569(1998)035<0111:cmiapw>2.3.co;2 ◽

1998 ◽

Vol 35 (2) ◽

pp. 111-119 ◽

Cited By ~ 16

Author(s):

Omar Gabriel da Silva Filho ◽

Rita de Cássia Moura Carvalho Lauris ◽

Leopoldino Capelozza Filho ◽

Gunvor Semb

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Adult Patients ◽

Craniofacial Morphology ◽

Bilateral Cleft Lip

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P-A Cephalometric Analysis of Nonoperated Adult Cleft Lip and Palate

The Cleft Palate-Craniofacial Journal ◽

10.1597/1545-1569_1994_031_0193_pacaon_2.3.co_2 ◽

1994 ◽

Vol 31 (3) ◽

pp. 193-200 ◽

Cited By ~ 2

Author(s):

Nobuyoshi Motohashi ◽

Takayuki Kuroda ◽

Leopoldino Capelozza Filho ◽

José Alberto De Souza Freitas

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Craniofacial Morphology ◽

Cephalometric Analysis ◽

Facial Morphology ◽

Facial Deformity ◽

Control Subjects ◽

Significant Difference ◽

Bilateral Cleft Lip ◽

The Comparative Study

P-A cephalometric analysis was performed on the craniofacial morphology in 88 Brazilian men with nonoperated and operated cleft lip and palate. For the comparative study, these subjects were divided into the following four groups: (1) 31 nonoperated unilateral cleft lip and palate (UCLP), (2) 24 nonoperated bilateral cleft lip and palate (BCLP), (3) 16 operated UCLP, (4) 17 operated BCLP. Thirty Brazilian men without cleft lip and palate were used as control subjects. In comparison with the control subjects, nonoperated BCLP and UCLP showed remarkable facial deformity characterized by Increased width of various facial parts. Facial morphology of surgically treated BCLP and UCLP, however, was very similar to that of noncleft subjects, apart from the Immediate cleft region. There was no remarkable difference in the facial morphology between nonoperated BCLP and UCLP, except for the cleft width and the deviation of nasal septum base, while the only significant difference between operated BCLP and UCLP was in the cleft width.

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Craniofacial Morphology of Dutch Patients with Bilateral Cleft Lip and Palate and Noncleft Controls at the Age of 15 Years

The Cleft Palate-Craniofacial Journal ◽

10.1597/07-166.1 ◽

2008 ◽

Vol 45 (6) ◽

pp. 661-666 ◽

Cited By ~ 22

Author(s):

Geer M. van den Dungen ◽

Edwin M. Ongkosuwito ◽

Irene H. A. Aartman ◽

Birte Prahl-Andersen

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Pearson Correlation ◽

Correlation Coefficients ◽

Craniofacial Morphology ◽

Control Group ◽

Class Iii ◽

Cross Sectional ◽

Significant Difference ◽

Bilateral Cleft Lip

Objective: Comparison of craniofacial morphology in bilateral cleft lip and palate patients to that of a noncleft control group at the age of 15 years. Design: A cross-sectional study of cephalometric data. Subjects and Methods: Cephalometric records of 41 consecutive patients (32 boys and 9 girls) with nonsyndromic complete bilateral cleft lip and palate born between 1973 and 1987. The patients were treated by the cleft teams of the Erasmus Medical Centre in Rotterdam and the VU University Amsterdam. The control group of normal Dutch subjects was followed in the Nijmegen Growth Study. From this population, mean cephalometric data were used. Differences in cephalometric measurements and other variables were calculated between the bilateral cleft lip and palate group and the control group. Results: Independent-sample t tests indicated that there was a statistically significant difference between the mean of the cephalometric values of the bilateral cleft lip and palate patients and the control group with respect to all cephalometric variables. Pearson correlation coefficients calculated between angle ANB and the number of operators, number of surgical procedures before 15 years of age, and the year of birth were not significant. Conclusions: Bilateral cleft lip and palate patients treated in the Amsterdam and Rotterdam cleft centers differed significantly from the control group in all measurements. A Class III development due to a less forward positioned maxilla was observed. The vertical measurements indicated a more divergent growth pattern in bilateral cleft lip and palate patients (Ans-Me/N-Me, GoGn-SN, and SN-FFH).

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A longitudinal three-center study of dental arch relationship in patients with bilateral cleft lip and palate

The Cleft Palate-Craniofacial Journal ◽

10.1597/08-249 ◽

2009 ◽

pp. 091202121239062

Author(s):

Theodosia Bartzela ◽

Christos Katsaros ◽

William Shaw ◽

Elisabeth Rønning ◽

Sara Rizell ◽

...

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Dental Arch ◽

Bilateral Cleft Lip ◽

Dental Arch Relationship ◽

Center Study

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A Longitudinal Three-Center Study of Dental Arch Relationship in Patients with Bilateral Cleft Lip and Palate

The Cleft Palate-Craniofacial Journal ◽

10.1597/08-249_1 ◽

2010 ◽

Vol 47 (2) ◽

pp. 167-174 ◽

Cited By ~ 3

Author(s):

Theodosia Bartzela ◽

Christos Katsaros ◽

William C. Shaw ◽

Elisabeth Rønning ◽

Sara Rizell ◽

...

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Dental Arch ◽

Bilateral Cleft Lip ◽

Dental Arch Relationship ◽

Center Study

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Influence of Lip Repair on Craniofacial Morphology of Patients with Complete Bilateral Cleft Lip and Palate

The Cleft Palate-Craniofacial Journal ◽

10.1597/1545-1569_2003_040_0144_iolroc_2.0.co_2 ◽

2003 ◽

Vol 40 (2) ◽

pp. 144-153 ◽

Cited By ~ 9

Author(s):

Omar Gabriel da Silva Filho ◽

José Valladares Neto ◽

Leopoldino Capelloza Filho ◽

JoséAlberto de Souza Freitas

Keyword(s):

Adult Male ◽

Significant Influence ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Cranial Base ◽

Craniofacial Morphology ◽

Bilateral Cleft Lip ◽

Male Patients ◽

Spatial Positioning ◽

Craniofacial Complex

Objective The aim of this study was to compare two groups of adult male patients with complete bilateral cleft lip and palate (BCLP) on the basis of lateral cephalometric radiographs. Patients The first group of adult male patients with complete BCLP was comprised of 13 unoperated patients with an average age of 21 years. The second group was comprised of 14 patients with an average age of 21 years 7 months, who had been operated only on the lip prior to 2 years of age. Design The following measurements were evaluated: angle and length of cranial base; maxillary spatial positioning and length; mandibular spatial positioning; morphology and length; maxillomandibular relationship; vertical facial length; dental positioning; interdental arch relationship; and soft profile. Results The results suggest that lip repair has a significant influence on certain areas of the craniofacial complex, mainly the premaxilla and the upper incisors. Conclusions The most significant findings consequent to lip repair consisted of reduction of the premaxillary anterior projection and lingual tipping of the upper incisors. Retropositioning of the premaxilla, especially in the alveolar part, is a desired effect of lip repair in complete BCLP. Such effect on the projected premaxilla is usually beneficial, except when the exceedingly severe lip pressure, unfavorable growth pattern, or both retropositions the midface profile beyond acceptable sagittal limits.

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