Early bone formation around immediately loaded implants with nanostructured calcium-incorporated and machined surface: a randomized, controlled histologic and histomorphometric study in the human posterior maxilla

Aim. To evaluate the effects of fixture design and surface on the early bone formation around immediately loaded implants inserted in the human posterior maxilla. Materials and Methods. Ten totally edentulous subjects received two transitional implants: one tapered implant with knife-edge threads/nanostructured calcium-incorporated surface (test: Anyridge®, Megagen, Gyeongbuk, South Korea) and one cylindrical implant with self-tapping threads/sandblasted surface (control: EZPlus®, Megagen). The implants were placed according to a split-mouth design and immediately loaded to support an interim complete denture; after 8 weeks, they were removed for histologic/histomorphometric analysis. The bone-to-implant contact (BIC%) and the bone density (BD%) were calculated. The Wilcoxon test was used to evaluate the differences. Results. With test implants, a mean BIC% and BD% of 35.9 (±9.1) and 31.8 (±7.5) were found. With control implants, a mean BIC% and BD% of 29.9 (±7.6) and 32.5 (±3.9) were found. The mean BIC% was higher with test implants, but this difference was not significant (p=0.16). Similar BD% were found in the two groups (p=0.9). Conclusions. In the posterior maxilla, under immediate loading conditions, implants with a knife-edge thread design/nanostructured calcium-incorporated surface seem to increase the peri-implant endosseous healing properties, when compared to implants with self-tapping thread design/sandblasted surface.

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The Influence of PRP on Early Bone Formation in Membrane Protected Defects. A Histological and Histomorphometric Study in the Rabbit Calvaria

Clinical Implant Dentistry and Related Research ◽

10.1111/j.1708-8208.2009.00266.x ◽

2011 ◽

Vol 13 (1) ◽

pp. 1-12 ◽

Cited By ~ 29

Author(s):

Nina Broggini ◽

Willy Hofstetter ◽

Ernst Hunziker ◽

Dieter D. Bosshardt ◽

Michael M. Bornstein ◽

...

Keyword(s):

Bone Formation ◽

Histomorphometric Study ◽

Early Bone Formation

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Early bone formation in mini‐lateral window sinus floor elevation with simultaneous implant placement: An in vivo experimental study

Clinical Oral Implants Research ◽

10.1111/clr.13714 ◽

2021 ◽

Author(s):

Liqin Zhu ◽

Jiakang Yang ◽

Jiaxing Gong ◽

Chenqiu Zhang ◽

Bernhard Ganss ◽

...

Keyword(s):

Experimental Study ◽

Bone Formation ◽

Sinus Floor Elevation ◽

Implant Placement ◽

Sinus Floor ◽

Early Bone Formation

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3D perfusion bioreactor-activated porous granules on implant fixation and early bone formation in sheep

Journal of Biomedical Materials Research Part B Applied Biomaterials ◽

10.1002/jbm.b.33783 ◽

2016 ◽

Vol 105 (8) ◽

pp. 2465-2476 ◽

Cited By ~ 1

Author(s):

Ming Ding ◽

Susan S. Henriksen ◽

Roberta Martinetti ◽

Søren Overgaard

Keyword(s):

Bone Formation ◽

Perfusion Bioreactor ◽

Implant Fixation ◽

Early Bone Formation

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Use of Platelet-Rich Fibrin Associated with Xenograft in Critical Bone Defects: Histomorphometric Study in Rabbits

Symmetry ◽

10.3390/sym11101293 ◽

2019 ◽

Vol 11 (10) ◽

pp. 1293

Author(s):

Paulo Wilson Maia ◽

Marcelo Lucchesi Teixeira ◽

Luís Guilherme Scavone de Macedo ◽

Antonio Carlos Aloise ◽

Celio Amaral Passos Junior ◽

...

Keyword(s):

Bone Formation ◽

Saline Solution ◽

Healing Process ◽

Test Group ◽

The Other ◽

Control Group ◽

Collagen Membrane ◽

Platelet Rich Fibrin ◽

Histomorphometric Study ◽

Significant Difference

Platelet-rich fibrin (PRF) is an autologous material used to improve bone regeneration when associated with bone grafts. It affects tissue angiogenesis, increasing the healing process and, theoretically, presenting potential to increase bone neoformation. The aim of this study was to verify, histomorphometrically, the effects of the association of PRF to a xenograft. Twelve adult white New Zealand rabbits were randomly assigned into two groups containing six animals each. After general anesthesia of the animals, two critical defects of 12 mm were created in the rabbit calvaria, one on each side of the sagittal line. Each defect was filled with the following biomaterials: in the control group (CG), xenograft hydrated with saline solution filling one defect and xenograft hydrated with saline solution covered with collagen membrane on the other side; in the test group (TG), xenograft associated with PRF filling the defect of one side and xenograft associated with PRF covered with collagen membrane on the other side. After eight weeks the animals were euthanized and a histomorphometric analysis was performed. The results showed that in the sites that were covered with collagen membrane, there was no statistically significant difference for all the analyzed parameters. However, when comparing the groups without membrane coverage, a statistically significant difference could be observed for the vital mineralized tissue (VMT) and nonmineralized tissue (NMT) parameters, with more VMT in the test group and more NMT in the control group. Regarding the intragroup comparison, the use of the membrane coverage presented significant outcomes in both groups. Therefore, in this experimental model, PRF did not affect the levels of bone formation when a membrane coverage technique was used. However, higher levels of bone formation were observed in the test group when membrane coverage was not used.

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