The Influence of PRP on Early Bone Formation in Membrane Protected Defects. A Histological and Histomorphometric Study in the Rabbit Calvaria

2011 ◽  
Vol 13 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Nina Broggini ◽  
Willy Hofstetter ◽  
Ernst Hunziker ◽  
Dieter D. Bosshardt ◽  
Michael M. Bornstein ◽  
...  
Keyword(s):  
Bone Formation ◽  
Histomorphometric Study ◽  
Early Bone Formation

scholarly journals Use of Platelet-Rich Fibrin Associated with Xenograft in Critical Bone Defects: Histomorphometric Study in Rabbits

Symmetry ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1293
Author(s):  
Paulo Wilson Maia ◽  
Marcelo Lucchesi Teixeira ◽  
Luís Guilherme Scavone de Macedo ◽  
Antonio Carlos Aloise ◽  
Celio Amaral Passos Junior ◽  
...  
Keyword(s):  
Bone Formation ◽  
Saline Solution ◽  
Healing Process ◽  
Test Group ◽  
The Other ◽  
Control Group ◽  
Collagen Membrane ◽  
Platelet Rich Fibrin ◽  
Histomorphometric Study ◽  
Significant Difference

Platelet-rich fibrin (PRF) is an autologous material used to improve bone regeneration when associated with bone grafts. It affects tissue angiogenesis, increasing the healing process and, theoretically, presenting potential to increase bone neoformation. The aim of this study was to verify, histomorphometrically, the effects of the association of PRF to a xenograft. Twelve adult white New Zealand rabbits were randomly assigned into two groups containing six animals each. After general anesthesia of the animals, two critical defects of 12 mm were created in the rabbit calvaria, one on each side of the sagittal line. Each defect was filled with the following biomaterials: in the control group (CG), xenograft hydrated with saline solution filling one defect and xenograft hydrated with saline solution covered with collagen membrane on the other side; in the test group (TG), xenograft associated with PRF filling the defect of one side and xenograft associated with PRF covered with collagen membrane on the other side. After eight weeks the animals were euthanized and a histomorphometric analysis was performed. The results showed that in the sites that were covered with collagen membrane, there was no statistically significant difference for all the analyzed parameters. However, when comparing the groups without membrane coverage, a statistically significant difference could be observed for the vital mineralized tissue (VMT) and nonmineralized tissue (NMT) parameters, with more VMT in the test group and more NMT in the control group. Regarding the intragroup comparison, the use of the membrane coverage presented significant outcomes in both groups. Therefore, in this experimental model, PRF did not affect the levels of bone formation when a membrane coverage technique was used. However, higher levels of bone formation were observed in the test group when membrane coverage was not used.

Locally enhanced early bone formation of zoledronic acid incorporated into a bone cement plugin vivo

2012 ◽  
Vol 65 (2) ◽  
pp. 201-212 ◽  
Author(s):  
Torben C. Sörensen ◽  
Jörg Arnoldi ◽  
Philip Procter ◽  
Claudia Beimel ◽  
Anders Jönsson ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Bone Formation ◽  
Bone Cement ◽  
Early Bone Formation

scholarly journals Histological Comparison of New Bone Formation Using Amnion Membrane Graft Versus Resorbable Collagen Membrane: An Animal Study

2018 ◽  
Vol 44 (5) ◽  
pp. 335-340 ◽  
Author(s):  
Soheil Koushaei ◽  
Mohammad Hassan Samandari ◽  
Sayed Mohammad Razavi ◽  
Ahad Khoshzaban ◽  
Shahriar Adibi ◽  
...  
Keyword(s):  
Bone Formation ◽  
Amniotic Membrane ◽  
Clinical Impact ◽  
Control Group ◽  
Collagen Membrane ◽  
New Bone Formation ◽  
Histomorphometric Study ◽  
Collagen Group ◽  
Group 12 ◽  
Amnion Membrane

The purpose of this article was to evaluate the bone induction effects of an amnion membrane–protected graft compared with a collagen membrane–protected graft in the repair of tibial bony defects in dogs. This study was performed using the tibial bone of dogs. After the removal of periosteum, similar holes were made with a 16-mm trephine drill (38 holes in total). For the study group, 10 holes were covered by absorbable collagen and 16 holes by amniotic membrane. In the control group, 12 holes were made and covered by the overlying soft tissue. Tibial bones were exposed after 6 and 12 weeks, and the samples were harvested and histologically processed. New bone formation was evaluated by histomorphometric study. Four Iranian mixed dogs older than 1.5 years were included in this study. The new bone formation was less in the control group when compared with the collagen group (P = .863). The collagen group showed less bone formation than the amnion group (P = .194), but this difference was not significant. However, bone formation in the amnion group was significantly more than in the control group (P = .050). Using the amniotic membrane appears to accelerate bone formation in guided bone regeneration. However, further studies should investigate its clinical impact on bone healing.

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