Lymphocytic Infiltration in Pediatric Thyroid Carcinomas

2004 ◽  
Vol 7 (5) ◽  
pp. 487-492 ◽  
Author(s):  
Van H. Savell ◽  
Stephen M. Hughes ◽  
Charles Bower ◽  
David M. Parham
Keyword(s):  
Papillary Carcinoma ◽  
Follicular Carcinoma ◽  
Thyroid Neoplasms ◽  
Lymphocytic Infiltration ◽  
Lymphocytic Infiltrate ◽  
Low Grade ◽  
Lymphoid Infiltrate ◽  
Thyroid Carcinomas ◽  
Thyroid Papillary ◽  
Adults And Children

Lymphocytic thyroiditis has been associated with an increase in the incidence of thyroid papillary carcinoma in some reports, mostly series of both adults and children. Relatively little is written about thyroiditis and follicular carcinomas. We have seen several cases of pediatric follicular thyroid carcinomas, that had an associated lymphocytic infiltrate, which led us to examine all primary malignant thyroid neoplasms in our surgical files from 1984 through 2000 to examine this relationship. We also investigated the nature of the lymphocytic infiltrate with routine immunohistochemistry. Ten patients (five male, five female, ages 4.5–21 years of age) had a thyroid carcinoma resection, six (three males and three females) with papillary carcinoma and four patients (two males and two females) with low-grade follicular carcinoma. Seven samples (one male had two cases with tumor) from patients who had a papillary carcinoma resection with tissue blocks available were identified (one patient had slides but no blocks), as were all four patients with a follicular carcinoma. The thyroid of all patients with a follicular carcinoma contained a lymphocytic infiltrate; only four of the seven papillary carcinoma samples had an associated lymphoid infiltrate. In all cases with a lymphoid infiltrate, the infiltrate was present in both lobes (both adjacent and separate from the tumor). B lymphocytes were present in the lymphoid infiltrate of three of four patients with follicular carcinomas and in 1 of 3 cases of papillary carcinomas. T cells were dispersed throughout all the tumors with lymphoid infiltrates. We conclude that pediatric follicular carcinomas have an associated lymphocytic infiltrate in the tumor and/or adjacent thyroid, more commonly than papillary carcinomas.

Recent Advances in the Classification of Low-grade Papillary-like Thyroid Neoplasms and Aggressive Papillary Thyroid Carcinomas

2018 ◽  
Vol 25 (4) ◽  
pp. 263-272 ◽  
Author(s):  
Zhenying Guo ◽  
Minghua Ge ◽  
Ying-Hsia Chu ◽  
Sofia Asioli ◽  
Ricardo V. Lloyd
Keyword(s):  
Thyroid Neoplasms ◽  
Low Grade ◽  
Papillary Thyroid ◽  
Thyroid Carcinomas ◽  
Recent Advances

scholarly journals Deregulation of microRNA expression in follicular cell-derived human thyroid carcinomas

2010 ◽  
Vol 17 (1) ◽  
pp. F91-F104 ◽  
Author(s):  
Pierlorenzo Pallante ◽  
Rosa Visone ◽  
Carlo Maria Croce ◽  
Alfredo Fusco
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Carcinoma ◽  
Thyroid Tissue ◽  
Endocrine System ◽  
Follicular Carcinoma ◽  
Thyroid Neoplasms ◽  
Anaplastic Thyroid Cancer ◽  
Microrna Expression ◽  
Human Thyroid ◽  
Thyroid Carcinomas

Carcinoma of the thyroid gland is an uncommon cancer, but one of the most frequent malignancies of the endocrine system. Most thyroid cancers are derived from the follicular cells. Follicular carcinoma is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one of the most lethal human cancers. Even though several genetic lesions have been already described in human thyroid cancer, particularly in the papillary histotype, the mechanisms underlying the development of these neoplasias are still far from being completely elucidated. Some years ago, several studies were undertaken to analyze the expression of microRNAs (miRNAs or miRs) in thyroid carcinoma to evaluate a possible role of their deregulation in the process of carcinogenesis. These studies showed an aberrant microRNA expression profile that distinguishes unequivocally among PTC, ATC, and normal thyroid tissue. Here, other than summarizing the current findings on microRNA expression in human thyroid carcinomas, we discuss the mechanisms by which microRNA deregulation may play a role in thyroid carcinogenesis, and the possible use of microRNA knowledge in the diagnosis and therapy of thyroid neoplasms.

DIFFERENTIATED THYROID CARCINOMAS ASSOCIATED WITH CHRONIC THYROIDITIS: BIOLOGICAL AND CLINICAL PROPERTIES

2018 ◽  
Vol 40 (2) ◽  
pp. 128-131 ◽  
Author(s):  
T M Myshunina ◽  
B D Guda ◽  
M Yu Bolgov ◽  
N I Mikhailenko ◽  
N D Tronko
Keyword(s):  
Tumor Growth ◽  
Lymph Nodes ◽  
Papillary Carcinoma ◽  
Tumor Size ◽  
Follicular Carcinoma ◽  
Disease Stage ◽  
Chronic Thyroiditis ◽  
Cervical Lymph Nodes ◽  
Thyroid Carcinomas ◽  
Carcinoma Metastasis

Aim: To determine biological and clinical features of papillary and follicular thyroid carcinomas associated or not associated with chronic thyroiditis. Materials and Methods: The study was conducted by retrospective analysis of medical histories of 2,459 patients with thyroid cancer. Tumor size, its category according to the TNM system, multi-focal properties of tumor growth, carcinoma invasiveness, as well as disease stage, rates of relapses and metastasis, and also cumulative survival rates were analyzed. Results: The tumor size in patients with papillary or follicular carcinoma associated with thyroiditis was smaller compared to the patients without thyroiditis. In the first case, the invasion frequency into extrathyroid structure and into the capsule was also lower. Multi-focal growth of both carcinoma types was registered more frequently in the presence of thyroiditis. The frequency of papillary carcinoma metastasis to lateral cervical lymph nodes was lower in the presence of thyroiditis, the frequency being equal for metastasis into lymph nodes of the VI lymph outflow zone in both groups of patients (with and without thyroiditis). In the presence of thyroiditis, the frequency of distant papillary carcinoma metastasis was decreased, no metastases were detected in patients with follicular carcinoma. In the group of patients with papillary carcinoma there was found no relation between the presence of thyroiditis and disease stage, relapse rates, and mortality levels; however, the risk of follicular carcinoma relapse was significantly lower in patients with thyroiditis. Conclusions: The presence of chronic thyroiditis in papillary carcinoma patients showed a certain positive impact on the course of the disease, in particular, primary tumor growth, invasion, and metastasis. Such effect is even more expressed in the patients with follicular thyroid carcinoma.

scholarly journals Pola kanker tiroid periode Juli 2013 – Juni 2016 di RSUP Prof. Dr. R. D Kandou Manado

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Yolanda Parura ◽  
Victor Pontoh ◽  
Marselus Werung
Keyword(s):  
Thyroid Cancer ◽  
Papillary Carcinoma ◽  
Malignant Disease ◽  
Endocrine System ◽  
Follicular Carcinoma ◽  
Female Gender ◽  
Medullary Carcinoma ◽  
Mountainous Areas ◽  
Thyroid Carcinomas ◽  
Histopathological Type

Abstract: Thyroid cancer is a common malignant disease found in endocrine system and is increasing in incidence every year, in Indonesia found around 9 from 10 malignancy. Based on histopathological types, thyroid carcinomas are divided into papillary carcinoma, follicular carcinoma, medullary carcinoma, and anaplastic carcinomas. The most common are papillary carcinoma and then follicular carcinoma. Factors that can influence the histopathological type of thyroid carcinomas is geographical factor, which most commonly found in mountainous areas. Thyroid cancer is rare in men, most often in women with a ratio of 1: 3.Conclusion: Female gender, mountainous terrain and adulthood to older people who suffered most thyroid cancer. Keywords: thyroid cancer Abstrak: Kanker tiroid penyakit keganasan tersering ditemukan pada sistim endokrin dan insidennya meningkat setiap tahun, di Indonesia menempati urutan 9 dari 10 keganasan yang sering ditemukan. Berdasarkan gambaran histopatologinya, karsinoma tiroid dibagi menjadi tipe papiler, folikuler, meduler, dan anaplastik. Kasus terbanyak adalah karsinoma tiroid papiler dan terbanyak kedua adalah karsinoma tiroid folikular. Salah satu faktor yang mempengaruhi gambaran histopatologi karsinoma tiroid adalah keadaan geografis, dimana paling banyak ditemukan pada daerah pegunungan. Kanker tiroid jarang terjadi pada laki-laki, paling sering pada perempuan dengan perbandingan 1:3. Simpulan: Jenis kelamin perempuan, daerah pegunungan dan usia dewasa sampai lanjut usia yang paling banyak menderita kanker tiroid. Kata kunci: kanker tiroid

Cystic cervical lymphadenopathy revealing thyroid papillary carcinoma

2020 ◽  
Author(s):  
Mehdi Hasnaoui ◽  
Mohamed Masmoudi ◽  
Takwa Belaid ◽  
Khalifa Mighri
Keyword(s):  
Papillary Carcinoma ◽  
Cervical Lymphadenopathy ◽  
Thyroid Papillary Carcinoma ◽  
Thyroid Papillary

scholarly journals Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: case report and review of the literature

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nadia De Falco ◽  
Giuseppe Santangelo ◽  
Fabrizio Chirico ◽  
Angelo Cangiano ◽  
Maria Giulia Sommella ◽  
...  
Keyword(s):  
Literature Review ◽  
Thyroid Carcinoma ◽  
Papillary Carcinoma ◽  
Parathyroid Carcinoma ◽  
Malignant Tumors ◽  
Gamma Probe ◽  
Differentiated Thyroid Carcinoma ◽  
Thyroid Carcinomas ◽  
First Case ◽  
Well Differentiated

Abstract Background Parathyroid carcinoma is a rare endocrine malignancy, rarer when synchronous with a non medullary well differentiated thyroid carcinoma. Parathyroid carcinoma accounts of 0.005% of all malignant tumors and it is responsible for less than 1% of primary hyperparathyroidism. The intrathyroidal localization of a parathyroid gland is not frequent with a reported prevalence of 0.2%. Carcinoma of parathyroids with intrathyroidal localization represents an even rarer finding, reported in only 16 cases described in literature. The rare constellation of synchronous parathyroid and thyroid carcinomas has prompted us to report our experience and perform literature review. Case presentation We herein report a case of a 63-years-old man with multinodular goiter and biochemical diagnosis of hyperparathyroidism. Total thyroidectomy with radio-guide technique using gamma probe after intraoperative sesta-MIBI administration and intraoperative PTH level was performed. The high radiation levels in the posterior thyroid lobe discovered an intrathyroidal parathyroid. Microscopic examination revealed a parathyroid main cell carcinoma at the posterior thyroidal left basal lobe, a classic papillary carcinoma at the same lobe and follicular variant of papillary carcinoma at the thyroidal right lobe. To the best of our knowledge, this is the first case documenting a synchronous multicentric non medullary thyroid carcinomas and intrathyroidal parathyroid carcinoma. Conclusions Our experience was reported and literature review underlining challenging difficulties in diagnostic workup and surgical management was carried out.

scholarly journals Pneumatosis intestinalis in a radioactive iodine-refractory metastasic thyroid papillary carcinoma with BRAFV600E mutation treated with dabrafenib–trametinib: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
M. C. Martín-Soberón ◽  
S. Ruiz ◽  
G. De Velasco ◽  
R. Yarza ◽  
A. Carretero ◽  
...  
Keyword(s):  
Case Report ◽  
Papillary Carcinoma ◽  
Radioactive Iodine ◽  
Specific Treatment ◽  
Pneumatosis Intestinalis ◽  
Thyroid Papillary Carcinoma ◽  
Intestinal Pneumatosis ◽  
Abdominal Symptoms ◽  
Positron Emission ◽  
Thyroid Papillary

Abstract Background Pneumatosis intestinalis (PI) is a rare entity which refers to the presence of gas within the wall of the small bowel or colon which is a radiographic sign. The etiology and clinical presentation are variable. Patients with PI may present either with chronic mild non-specific symptoms or with acute abdominal pain with peritonitis. Some cases of intestinal pneumatosis have been reported as adverse events of new oncological treatments such as targeted therapies that are widely used in multiple tumors. Case presentation A 59-year-old caucasian female with radioactive iodine-refractory metastatic thyroid papillary carcinoma with BRAFV600E mutation was treated with dabrafenib and trametinib as a compassionate use. After 4 months treatment, positron emission tomography–computed tomography (PET–CT) showed PI. At the time of diagnosis, the patient was asymptomatic without signs of peritonitis. The initial treatment was conservative and no specific treatment for PI was needed. Unfortunately, after dabrafenib–trametinib withdrawal, the patient developed tumor progression with significant clinical worsening. Conclusions This case report is, in our knowledge, the first description of PI in a patient treated with dabrafenib–trametinib. Conservative treatment is feasible if there are no abdominal symptoms.

scholarly journals ResCaps: an improved capsule network and its application in ultrasonic image classification of thyroid papillary carcinoma

2021 ◽  
Author(s):  
Xiongzhi Ai ◽  
Jiawei Zhuang ◽  
Yonghua Wang ◽  
Pin Wan ◽  
Yu Fu
Keyword(s):  
Papillary Carcinoma ◽  
Network Model ◽  
Reliability And Validity ◽  
Thyroid Papillary Carcinoma ◽  
Data Set ◽  
Ultrasonic Image ◽  
First Choice ◽  
Thyroid Papillary ◽  
Ultrasonic Images

AbstractUltrasonic image examination is the first choice for the diagnosis of thyroid papillary carcinoma. However, there are some problems in the ultrasonic image of thyroid papillary carcinoma, such as poor definition, tissue overlap and low resolution, which make the ultrasonic image difficult to be diagnosed. Capsule network (CapsNet) can effectively address tissue overlap and other problems. This paper investigates a new network model based on capsule network, which is named as ResCaps network. ResCaps network uses residual modules and enhances the abstract expression of the model. The experimental results reveal that the characteristic classification accuracy of ResCaps3 network model for self-made data set of thyroid papillary carcinoma was $$81.06\%$$ 81.06 % . Furthermore, Fashion-MNIST data set is also tested to show the reliability and validity of ResCaps network model. Notably, the ResCaps network model not only improves the accuracy of CapsNet significantly, but also provides an effective method for the classification of lesion characteristics of thyroid papillary carcinoma ultrasonic images.

scholarly journals Advanced thyroid carcinomas: neural network analysis of ultrasonographic characteristics

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Michael Cordes ◽  
Theresa Ida Götz ◽  
Elmar Wolfgang Lang ◽  
Stephan Coerper ◽  
Torsten Kuwert ◽  
...  
Keyword(s):  
Neural Network ◽  
Imaging Modality ◽  
Follicular Carcinoma ◽  
Predictive Values ◽  
Thyroid Carcinomas ◽  
The Neural Network ◽  
Group 2 ◽  
Line Imaging ◽  
Hidden Layer ◽  
Group 1

Abstract Background Ultrasound is the first-line imaging modality for detection and classification of thyroid nodules. Certain characteristics observable by ultrasound have recently been identified that may indicate malignancy. This retrospective cohort study was conducted to test the hypothesis that advanced thyroid carcinomas show distinctive clinical and sonographic characteristics. Using a neural network model as proof of concept, nine clinical/sonographic features served as input. Methods All 96 study enrollees had histologically confirmed thyroid carcinomas, categorized (n = 32, each) as follows: group 1, advanced carcinoma (ADV) marked by local invasion or distant metastasis; group 2, non-advanced papillary carcinoma (PTC); or group 3, non-advanced follicular carcinoma (FTC). Preoperative ultrasound profiles were obtained via standardized protocols. The neural network had nine input neurons and one hidden layer. Results Mean age and the number of male patients in group 1 were significantly higher compared with groups 2 (p = 0.005) or 3 (p <  0.001). On ultrasound, tumors of larger volume and irregular shape were observed significantly more often in group 1 compared with groups 2 (p <  0.001) or 3 (p ≤ 0.01). Network accuracy in discriminating advanced vs. non-advanced tumors was 84.4% (95% confidence interval [CI]: 75.5–91), with positive and negative predictive values of 87.1% (95% CI: 70.2–96.4) and 92.3% (95% CI: 83.0–97.5), respectively. Conclusions Our study has shown some evidence that advanced thyroid tumors demonstrate distinctive clinical and sonographic characteristics. Further prospective investigations with larger numbers of patients and multicenter design should be carried out to show whether a neural network incorporating these features may be an asset, helping to classify malignancies of the thyroid gland.

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