Infliximab improves bone metabolism and bone mineral density in rheumatoid arthritis and ankylosing spondylitis: a prospective 2-year study

2012 ◽  
Vol 32 (3) ◽  
pp. 377-381 ◽  
Author(s):  
Gabriel Dischereit ◽  
Ingo H. Tarner ◽  
Ulf Müller-Ladner ◽  
Uwe Lange
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Ankylosing Spondylitis ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Mineral Density

Anti-TNFS effects on bone mineral density and bone metabolism in rheumatoid arthritis: Focus on etanercept

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S427
Author(s):  
C. Ancuta ◽  
E. Ancuta ◽  
C. Iordache ◽  
S. Miu ◽  
R. Chirieac
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Mineral Density

Abnormalities of Bone Mineral Density and Bone Metabolism in Venezuelan Patients with Rheumatoid Arthritis

2003 ◽  
Vol 9 (4) ◽  
pp. 219-227 ◽  
Author(s):  
Fanny Manrique ◽  
Jesaida Gamardo ◽  
Karem de Elguezabal ◽  
Ruby Martinis ◽  
Julio S. Castro ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals Effects of 1-year anti-TNF-α therapies on bone mineral density and bone biomarkers in rheumatoid arthritis and ankylosing spondylitis

2019 ◽  
Vol 39 (1) ◽  
pp. 167-175 ◽  
Author(s):  
Katalin Gulyás ◽  
Ágnes Horváth ◽  
Edit Végh ◽  
Anita Pusztai ◽  
Ágnes Szentpétery ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Ankylosing Spondylitis ◽  
Bone Loss ◽  
Bone Mineral ◽  
Certolizumab Pegol ◽  
Joint Destruction ◽  
Type I ◽  
Mineral Density ◽  
Tnf Α

Abstract Objectives Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) have been associated with generalized and localized bone loss. We conducted a comprehensive study using imaging (dual-energy X-ray absorptiometry, DXA) and laboratory biomarkers in order to determine bone health and to study the effects of anti-tumor necrosis factor (TNF) biologics in RA and AS. Patients and methods Thirty-six RA and 17 AS patients undergoing 1-year etanercept (ETN) or certolizumab-pegol (CZP) therapy were studied. Bone density was assessed by DXA at baseline and after 12 months. Serum C-reactive protein (CRP), calcium, phosphate, parathyroid hormone (PTH), vitamin D3, osteocalcin, procollagen type I N-propeptide (P1NP), C-terminal telopeptide (βCTX), osteoprotegerin, sclerostin (SOST), Dickkopf-1 (DKK-1), soluble receptor activator nuclear kappa B ligand (sRANKL), and cathepsin K (cathK) levels were determined at baseline and after 6 and 12 months. Results TNF-α inhibition was clinically effective. Anti-TNF-α halted further bone loss over 1 year. In general, anti-TNF therapy significantly increased P1NP, SOST levels, and the P1NP/βCTX ratios, while decreased DKK-1 and CathK production at different time points in most patient subsets. In the full cohort and in RA, baseline and/or 12-month bone mineral density (BMD) at multiple sites exerted inverse relationships with CRP and βCTX, and positive correlation with SOST. In AS, L2-4 BMD after 1-year biologic therapy inversely correlated with baseline βCTX, while femoral neck BMD rather showed inverse correlations with CRP. Conclusions Anti-TNF therapy slowed down generalized bone loss, in association with clinical improvements, in both diseases. TNF blockade may enhance bone formation and suppress joint destruction. Anti-TNF therapy may act inversely on DKK-1 and SOST. Independent predictors of BMD were SOST and βCTX in RA, whilst CRP in AS.Key Points• One-year anti-TNF therapy halted generalized bone loss in association with clinical improvement in arthritides.• Anti-TNF therapy may inversely act on DKK-1 and SOST.• Independent predictors of BMD were SOST and βCTX in RA, while CRP in AS.

scholarly journals Changes and comparison of bone metabolism, bone mineral density, MRI in early rheumatoid arthritis

2013 ◽  
Author(s):  
Diana Vershhynina ◽  
Varerij Ryzhyk ◽  
Olena Mikhalchenko ◽  
Iryna Golovach ◽  
Peter Dudij ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Early Rheumatoid Arthritis ◽  
Mineral Density
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