Association between comorbidities and extraglandular manifestations in primary Sjögren’s syndrome: a multicenter cross-sectional study

2020 ◽  
Vol 39 (9) ◽  
pp. 2677-2688
Author(s):  
Yuying Zhang ◽  
Mengtao Li ◽  
Liyun Zhang ◽  
Qin Li ◽  
Pinting Yang ◽  
...  
Keyword(s):  
Sjogren’S Syndrome ◽  
Cross Sectional Study ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Sectional Study ◽  
Primary Sjogren’S Syndrome ◽  
Cross Sectional ◽  
Primary Sjögren's Syndrome ◽  
Extraglandular Manifestations ◽  
Sjögren‘S Syndrome

scholarly journals Peripheral regulatory cells immunophenotyping in Primary Sjögren's Syndrome: a cross-sectional study

2013 ◽  
Vol 15 (3) ◽  
pp. R68 ◽  
Author(s):  
Janette Furuzawa-Carballeda ◽  
Gabriela Hernández-Molina ◽  
Guadalupe Lima ◽  
Yahaira Rivera-Vicencio ◽  
Karen Férez-Blando ◽  
...  
Keyword(s):  
Sjogren’S Syndrome ◽  
Cross Sectional Study ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Regulatory Cells ◽  
Sectional Study ◽  
Primary Sjogren’S Syndrome ◽  
Cross Sectional ◽  
Primary Sjögren's Syndrome ◽  
Sjögren‘S Syndrome

scholarly journals Correlation of sleep quality with fatigue and disease activity among patients with primary Sjögren’s syndrome: a cross-sectional study

2020 ◽  
Vol 138 (2) ◽  
pp. 146-151 ◽  
Author(s):  
Luciana Paula Dardin ◽  
Ana Beatriz Andreo Garcia ◽  
Fernanda Martins Gazoni ◽  
Fania Cristina dos Santos ◽  
Marco Tulio de Mello ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Disease Activity ◽  
Sjogren’S Syndrome ◽  
Cross Sectional Study ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Sectional Study ◽  
Primary Sjogren’S Syndrome ◽  
Cross Sectional ◽  
Primary Sjögren's Syndrome

scholarly journals Discordant Predictions of Extraglandular Involvement in Primary Sjögren’s Syndrome According to the Anti-SSA/Ro60 Antibodies Detection Assay in a Cohort Study

2022 ◽  
Vol 11 (1) ◽  
pp. 242
Author(s):  
Geoffrey Urbanski ◽  
Aline Gury ◽  
Pascale Jeannin ◽  
Alain Chevailler ◽  
Pierre Lozac’h ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Extraglandular Manifestations ◽  
Antibodies Detection ◽  
Sjögren‘S Syndrome

Electrophoresis-derived techniques for anti-SSA/Ro60 KDa (anti-SSA) antibodies detection have been progressively replaced by methods using non-native antigens. We aimed to compare the patients’ phenotypes and the occurrence of extraglandular manifestations in primary Sjögren’s syndrome according to the method used to detect anti-SSA antibodies. Sera from patients with a diagnosis of pSS according to ACR/EULAR 2016 criteria between 2008 and 2017 were tested for anti-SSA antibodies using methods with non-native antigens (magnetic bead multiplex assay; line immunoassays) and one with native antigens (counterimmunoelectrophoresis (CIE)). The population was split into three groups according to anti-SSA antibodies status: absence (SSA−), presence in any method except for CIE (SSA+CIE−), and presence in CIE (SSA+CIE+). The patients in the SSA+CIE+ group (n = 70, 42.7%) were ten years younger and presented more immunological activity compared with both the SSA− (n = 80, 48.8%) and SSA+CIE− groups (n = 14, 8.5%). The SSA− and SSA+CIE− groups were poorly distinct. The presence of anti-SSA antibodies solely in CIE was significantly associated with the occurrence of extraglandular manifestations of pSS (HR = 4.45 (2.35–8.42)). Contrary to CIE, methods using non-native antigens to detect anti-SSA antibodies were unable to predict the occurrence of systemic expression of pSS.

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