Expression of Toll-like receptors 2 and 4 in the saliva of patients with systemic lupus erythematosus and chronic periodontitis

2021 ◽  
Author(s):  
Consuelo P. C. Marques ◽  
Vandilson P. Rodrigues ◽  
Larissa C. de Carvalho ◽  
Louise P. Nichilatti ◽  
Mayra M. Franco ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Chronic Periodontitis ◽  
Toll Like Receptors ◽  
Systemic Lupus

Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: Ethnic differences and potential new targets for therapeutic drugs

2014 ◽  
Vol 61 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Beverly D. Lyn-Cook ◽  
Chenghui Xie ◽  
Jarren Oates ◽  
Edward Treadwell ◽  
Beverly Word ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Ethnic Differences ◽  
Lupus Erythematosus ◽  
Toll Like Receptors ◽  
Systemic Lupus ◽  
New Targets ◽  
Therapeutic Drugs

Vitamin D3 Alters the Expression of Toll-like Receptors in Peripheral Blood Mononuclear Cells of Patients With Systemic Lupus Erythematosus

2017 ◽  
Vol 118 (12) ◽  
pp. 4831-4835 ◽  
Author(s):  
Esmaeil Yazdanpanah ◽  
Mahmoud Mahmoudi ◽  
Maryam Sahebari ◽  
Zahra Rezaieyazdi ◽  
Seyed-Alireza Esmaeili ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Peripheral Blood Mononuclear Cells ◽  
Vitamin D3 ◽  
Lupus Erythematosus ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Toll Like Receptors ◽  
Systemic Lupus ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

scholarly journals Interferon Regulatory Factor 5 in the Pathogenesis of Systemic Lupus Erythematosus

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Candace M. Cham ◽  
Kichul Ko ◽  
Timothy B. Niewold
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Immune Complexes ◽  
Interferon Regulatory Factor ◽  
Immune Defense ◽  
Toll Like Receptors ◽  
Regulatory Factor ◽  
Systemic Lupus ◽  
Interferon Regulatory Factor 5

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple genetic risk factors, high levels of interferon alpha (IFN-α), and the production of autoantibodies against components of the cell nucleus. Interferon regulatory factor 5 (IRF5) is a transcription factor which induces the transcription of IFN-αand other cytokines, and genetic variants of IRF5 have been strongly linked to SLE pathogenesis. IRF5 functions downstream of Toll-like receptors and other microbial pattern-recognition receptors, and immune complexes made up of SLE-associated autoantibodies seem to function as a chronic endogenous stimulus to this pathway. In this paper, we discuss the physiologic role of IRF5 in immune defense and the ways in whichIRF5variants may contribute to the pathogenesis of human SLE. Recent data regarding the role ofIRF5in both serologic autoimmunity and the overproduction of IFN-αin human SLE are summarized. These data support a model in which SLE-risk variants of IRF5 participate in a “feed-forward” mechanism, predisposing to SLE-associated autoantibody formation, and subsequently facilitating IFN-αproduction downstream of Toll-like receptors stimulated by immune complexes composed of these autoantibodies.

Role for toll-like receptors in autoimmune disease: The example of systemic lupus erythematosus

2011 ◽  
Vol 78 (2) ◽  
pp. 124-130 ◽  
Author(s):  
Christophe Richez ◽  
Patrick Blanco ◽  
Ian Rifkin ◽  
Jean-François Moreau ◽  
Thierry Schaeverbeke
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Lupus Erythematosus ◽  
Toll Like Receptors ◽  
Systemic Lupus

The role of toll-like receptors in systemic lupus erythematosus

2006 ◽  
Vol 28 (2) ◽  
pp. 131-143 ◽  
Author(s):  
Adeeb H. Rahman ◽  
Robert A. Eisenberg
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Toll Like Receptors ◽  
Systemic Lupus

Is chronic periodontitis premature in systemic lupus erythematosus patients?

2016 ◽  
Vol 36 (3) ◽  
pp. 713-718 ◽  
Author(s):  
Débora Cerqueira Calderaro ◽  
Gilda Aparecida Ferreira ◽  
Jôice Dias Corrêa ◽  
Santuza Maria Souza Mendonça ◽  
Tarcília Aparecida Silva ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Chronic Periodontitis ◽  
Systemic Lupus
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