Induction of apoptosis in cervical carcinoma HeLa cells by Petasites japonicus ethanol extracts

2015 ◽  
Vol 24 (2) ◽  
pp. 665-672 ◽  
Author(s):  
Yu-Jin Hwang ◽  
Hae-Ri Wi ◽  
Haeng-Ran Kim ◽  
Kye Won Park ◽  
Kyung-A Hwang
2013 ◽  
Vol 48 (1) ◽  
pp. 68-72 ◽  
Author(s):  
Isuru Wijesekara ◽  
Yong-Xin Li ◽  
Thanh-Sang Vo ◽  
Quang Van Ta ◽  
Dai-Hung Ngo ◽  
...  

2016 ◽  
Vol 11 (2) ◽  
pp. 337
Author(s):  
Jing Sun ◽  
Jing Wu ◽  
Li Zhang ◽  
Qi-Yue Wan ◽  
Li-Ci Wang ◽  
...  

<p>The current study demonstrates the effect of plumericin on the viability and induction of apoptosis through degradation of double helical DNA structure in Bu25TK and HeLa cervical carcinoma cell lines. Plumericin treatment exhibited concentration- and time-dependent effect on the viability of Bu25TK and HeLa cells. Incubation of Bu25TK and HeLa cells with 40 µM concen-tration of plumericin decreased cell viability to 24 and 29%, respectively after 48 hours. Plumericin treatment also caused significant increase in the proportion of apoptotic cells in both the cell lines at 40 µM concentration compared to the control cells. Examination of the DNA double helical structure after 48 hours of treatment with plumericin at 40 µM concentration showed DNA degradation and formation of comets. Thus, plumericin exhibits inhibitory effect on the viability of Bu25TK and HeLa cells and induced apoptosis through DNA degradation. Therefore, plumericin is a potent candidate for the treatment of cervical carcinoma.</p><p> </p>


1996 ◽  
Vol 55 (6) ◽  
pp. 403-411 ◽  
Author(s):  
M. de Kock ◽  
M.-L. Lottering ◽  
C.J.S. Grobler ◽  
T.C. Viljoen ◽  
M. le Roux ◽  
...  

2009 ◽  
Vol 76 (5) ◽  
pp. 998-1010 ◽  
Author(s):  
Sergio Anguissola ◽  
Barbara Köhler ◽  
Robert O'Byrne ◽  
Heiko Düssmann ◽  
Mary D. Cannon ◽  
...  

2016 ◽  
Vol 11 (4) ◽  
pp. 2440-2444 ◽  
Author(s):  
PING JIANG ◽  
YA-LI REN ◽  
JIA-LIANG LI ◽  
JUN LUO

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