The role of coupling strength and internal delay between compartments in shaping the bursting behavior of cortical neuron

2014 ◽  
Vol 35 (6) ◽  
pp. 883-889 ◽  
Author(s):  
Lei Wang ◽  
Yanjun Zeng
2001 ◽  
Vol 37 (4) ◽  
pp. 2411-2413 ◽  
Author(s):  
You Xu ◽  
Jiehui Yang ◽  
Xijuan Zhang ◽  
Fang Zhang ◽  
M. Guillot

Micromachines ◽  
2018 ◽  
Vol 9 (12) ◽  
pp. 663 ◽  
Author(s):  
Wei Gao ◽  
Xuan Zhang ◽  
Xiaotian Han ◽  
Chaoqun Shen

A two-dimensional molecular dynamics model of the liquid flow inside rough nanochannels is developed to investigate the effect of a solid wall on the interface slip of liquid in nanochannels with a surface roughness constructed by rectangular protrusions. The liquid structure, velocity profile, and confined scale on the boundary slip in a rough nanochannel are investigated, and the comparison of those with a smooth nanochannel are presented. The influence of solid wall properties, including the solid wall density, wall-fluid coupling strength, roughness height and spacing, on the interfacial velocity slip are all analyzed and discussed. It is indicated that the rough surface induces a smaller magnitude of the density oscillations and extra energy losses compared with the smooth solid surface, which reduce the interfacial slip of liquid in a nanochannel. In addition, once the roughness spacing is very small, the near-surface liquid flow dominates the momentum transfer at the interface between liquid and solid wall, causing the role of both the corrugation of wall potential and wall-fluid coupling strength to be less obvious. In particular, the slip length increases with increasing confined scales and shows no dependence on the confined scale once the confined scale reaches a critical value. The critical confined scale for the rough channel is larger than that of the smooth scale.


Nanoscale ◽  
2020 ◽  
Vol 12 (21) ◽  
pp. 11612-11618
Author(s):  
Manish Kumar ◽  
Jyotirban Dey ◽  
Mrigank Singh Verma ◽  
Manabendra Chandra

Single particle spectroscopy unravels the exact role of one specific plasmon dephasing channel, radiation damping, in controlling plasmon–exciton coupling in Au nanorod-J-aggregate hybrids.


2009 ◽  
Vol 20 (38) ◽  
pp. 385401 ◽  
Author(s):  
Xin Shen ◽  
Zelong Yi ◽  
Ziyong Shen ◽  
Xingyu Zhao ◽  
Jinlei Wu ◽  
...  

Author(s):  
Lena Will ◽  
Sybren Portegies ◽  
Jasper van Schelt ◽  
Merel van Luyk ◽  
Dick Jaarsma ◽  
...  

Abstract For the proper organization of the six-layered mammalian neocortex it is required that neurons migrate radially from their place of birth towards their designated destination. The molecular machinery underlying this neuronal migration is still poorly understood. The dynein-adaptor protein BICD2 is associated with a spectrum of human neurological diseases, including malformations of cortical development. Previous studies have shown that knockdown of BICD2 interferes with interkinetic nuclear migration in radial glial progenitor cells, and that Bicd2-deficient mice display an altered laminar organization of the cerebellum and the neocortex. However, the precise in vivo role of BICD2 in neocortical development remains unclear. By comparing cell-type specific conditional Bicd2 knock-out mice, we found that radial migration in the cortex predominantly depends on BICD2 function in post-mitotic neurons. Neuron-specific Bicd2 cKO mice showed severely impaired radial migration of late-born upper-layer neurons. BICD2 depletion in cortical neurons interfered with proper Golgi organization, and neuronal maturation and survival of cortical plate neurons. Single-neuron labeling revealed a specific role of BICD2 in bipolar locomotion. Rescue experiments with wildtype and disease-related mutant BICD2 constructs revealed that a point-mutation in the RAB6/RANBP2-binding-domain, associated with cortical malformation in patients, fails to restore proper cortical neuron migration. Together, these findings demonstrate a novel, cell-intrinsic role of BICD2 in cortical neuron migration in vivo and provide new insights into BICD2-dependent dynein-mediated functions during cortical development.


2011 ◽  
Vol 7 ◽  
pp. S523-S523
Author(s):  
Rosa Solano ◽  
Maria Casarejos ◽  
Ana Gomez ◽  
Juan Perucho ◽  
Justo de Yébenes ◽  
...  

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