Evaluation of different treatment protocols for dentin hypersensitivity: an 18-month randomized clinical trial

Oral lichen planus (OLP) is a chronic, inflammatory, immune-mediated disease, which can alter the quality of life of patients. The aim of this randomized clinical trial was to compare the therapeutic efficacy of clobetasol oral gel 0.05% versus an anti-inflammatory in oral solution (mouthwash) in the management of patients suffering from symptomatic OLP. The secondary objective was to analyze which one of the two treatments induced a greater risk of developing side effects. Forty patients were assigned (20 patients for group), through a randomized design, to receive clobetasol gel 0.05% or an anti-inflammatory mouthwash, which contains calcium hydroxide, hyaluronic acid, umbelliferone and oligomeric pro-anthocyanidins) for three months. At baseline (T0) and after 3 months (T1), patients underwent dental and dermatological examinations to assess their symptoms (Numerical Pain Scale (NRS) score) and signs (Thongprasom score). Data were calculated using T-test for the dependent variable, Wilcoxon test and Mann-Whitney u test. Both clobetasol and anti-inflammatory resulted in a statistically significant reduction of signs, (p < 0.001 and p = 0.02, respectively) and symptoms (p < 0.001 for clobetasol and p = 0.02 for anti-inflammatory). In conclusion, the results evidenced that, compared to clobetasol, the anti-inflammatory was less effective in determining the reduction of signs and symptom in OLP patients.

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Four-Session Protocol Effectiveness in Reducing Cervical Dentin Hypersensitivity: A 24-Week Randomized Clinical Trial

Photobiomodulation Photomedicine and Laser Surgery ◽

10.1089/photob.2018.4477 ◽

2019 ◽

Vol 37 (2) ◽

pp. 117-123 ◽

Cited By ~ 1

Author(s):

Guilherme Faria Moura ◽

Lívia Fávaro Zeola ◽

Michele Borges Silva ◽

Sônia Cristina Sousa ◽

Fernanda Rodrigues Guedes ◽

...

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Dentin Hypersensitivity

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Dental Fluorosis Treatment Can Improve the Individuals’ OHRQoL? Results from a Randomized Clinical Trial

Brazilian Dental Journal ◽

10.1590/0103-6440201801733 ◽

2018 ◽

Vol 29 (2) ◽

pp. 109-116 ◽

Cited By ~ 2

Author(s):

Sônia Saeger Meireles ◽

Marilia Leão Goettems ◽

Kaline Silva Castro ◽

Fábio Correia Sampaio ◽

Flávio Fernando Demarco

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Endemic Area ◽

Dental Fluorosis ◽

Tooth Bleaching ◽

Treatment Protocols ◽

Treatment Groups ◽

Anterior Teeth ◽

Related Quality ◽

At Home

Abstract This study aimed to evaluate the effect on oral health-related quality of life (OHRQoL) of two treatment protocols for dental fluorosis in individuals enrolled in a randomized clinical trial. Seventy volunteers, who lived in a fluorosis endemic area in Brazil, and had at least four maxillary anterior teeth showing fluorosis with a Thylstrup and Fejerskov index from 1 to 7, were randomized into two treatment groups (n= 35): GI- enamel microabrasion; or GII- microabrasion associated with at-home bleaching. Microabrasion was performed using 37% phosphoric acid and pumice, and at-home tooth bleaching with 10% carbamide peroxide in a tray. Volunteers completed a questionnaire at baseline and 1-month post treatment to assess changes in OHRQoL, using the Oral Impact on Daily Performance (OIDP). Differences in overall impact scores between and within treatment groups were analyzed with Wilcoxon (within) and Mann-Whitney (between) tests. Changes in performance scores were analyzed using Wilcoxon tests (a< 0.05). One month after treatment, subjects reported improvement in OHRQoL. Both groups showed lower OIDP scores (p< 0.001), but there was no difference between them. Eating, cleaning teeth, smiling and emotional state performance scores were lower after treatment for the whole sample. In conclusion, the treatment with microabrasion improved the OHRQoL in this sample of individuals living in a fluorosis endemic area regardless of the addition of at-home bleaching.

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