Preoperative biliary drainage-related inflammation is associated with shorter survival in biliary tract cancer patients

2016 ◽  
Vol 21 (5) ◽  
pp. 934-939 ◽  
Author(s):  
Hiroshi Kurahara ◽  
Kosei Maemura ◽  
Yuko Mataki ◽  
Masahiko Sakoda ◽  
Satoshi Iino ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Biliary Drainage ◽  
Preoperative Biliary Drainage ◽  
Tract Cancer

scholarly journals CA19-9 or CEA Decline after the First Cycle of Treatment Predicts Survival in Advanced Biliary Tract Cancer Patients Treated with S-1 and Cisplatin Chemotherapy

2017 ◽  
Vol 49 (3) ◽  
pp. 807-815 ◽  
Author(s):  
Dae-Won Lee ◽  
Seock-Ah Im ◽  
Yu Jung Kim ◽  
Yaewon Yang ◽  
Jiyoung Rhee ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Tract Cancer

Incidence and risk factors for cholangitis during systemic chemotherapy among patients with advanced biliary tract cancer.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 313-313 ◽  
Author(s):  
J. Hashimoto ◽  
C. Morizane ◽  
S. Kondo ◽  
H. Ueno ◽  
S. Mitsunaga ◽  
...  
Keyword(s):  
Risk Factors ◽  
Median Time ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Biliary Drainage ◽  
Systemic Chemotherapy ◽  
Sphincter Of Oddi ◽  
Ampullary Cancer ◽  
First Episode ◽  
Tract Cancer

313 Background: Patients with biliary tract cancer (BTC) have a high risk of developing cholangitis. In patients with advanced BTC receiving systemic chemotherapy, cholangitis might interfere with the execution of the treatment. Furthermore, cholangitis during severe immunosuppression might develop into lethal complications such as sepsis or shock. Purpose: To determine the incidence of cholangitis among patients with advanced BTC undergoing systemic chemotherapy and to identify risk factors for the development of cholangitis. Methods: We reviewed the records of 301 patients with advanced BTC who received systemic chemotherapy at our hospital between February 2002 and July 2009. The clinical data of patients treated with gemcitabine monotherapy (GEM) as a first-line chemotherapy was retrieved. Results: One hundred and thirty-one patients were successfully followed up throughout the entire GEM treatment. Forty-three patients had intrahepatic BTC (32.8%), 28 had extrahepatic BTC (21.4%), 11 had hilar BTC (8.4%), 7 had ampullary cancer (5.3%), and 42 had gallbladder cancer (32.1%). Interventional radiological treatment or biliary reconstruction for biliary obstruction was performed in 50 patients (37.9%) prior to the start of chemotherapy. The median time to GEM treatment failure was 126 days. Cholangitis developed in 30 patients (22.9%) during GEM, and severe cholangitis developed in 10 patients (7.6%). The median time to the first episode of cholangitis from the start of chemotherapy was 65 days. Chemotherapy was discontinued because of cholangitis in 4 patients (3.1%), but no deaths as a result of cholangitis occurred. A multivariate analysis using a logistic regression model demonstrated that the presence of hilar obstruction (p=0.0002, OR: 10.748), the loss of sphincter of Oddi function (p=0.0005,OR: 8.960), and the presence of internal biliary drainage (p=0.007, OR: 4.472) were independent risk factors of cholangitis. Conclusions: The incidence of cholangitis during GEM treatment was 22.9% among the advanced BTC patients in this study. Hilar obstruction, the loss of sphincter of Oddi function, and internal biliary drainage may be risk factors of cholangitis. No significant financial relationships to disclose.

scholarly journals Expression of insulin-like growth factor I receptor as a biomarker for predicting prognosis in biliary tract cancer patients

2015 ◽  
Vol 3 (3) ◽  
pp. 464-470 ◽  
Author(s):  
HIDEO SUZUKI ◽  
JUAN C. ROA ◽  
TORU KAWAMOTO ◽  
KAZUNORI ISHIGE ◽  
IGNACIO I. WISTUBA ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cancer Patients ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Insulin Like Growth Factor ◽  
Tract Cancer ◽  
Factor I ◽  
Growth Factor I

scholarly journals Changes in hepatic lobe volume in biliary tract cancer patients after right portal vein embolization

Hepatology ◽  
1995 ◽  
Vol 21 (2) ◽  
pp. 434-439 ◽  
Author(s):  
Masato Nagino ◽  
Yuji Nimura ◽  
Junichi Kamiya ◽  
Satoshi Kondo ◽  
Katsuhiko Uesaka ◽  
...  
Keyword(s):  
Portal Vein ◽  
Cancer Patients ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Portal Vein Embolization ◽  
Hepatic Lobe ◽  
Tract Cancer

LDH serum levels as prognostic and predictive factor in advanced biliary tract cancer patients treated with first-line chemotherapy.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 313-313
Author(s):  
Luca Faloppi ◽  
Michela Del Prete ◽  
Mario Scartozzi ◽  
Daniele Santini ◽  
Maristella Bianconi ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Serum Levels ◽  
First Line ◽  
Tract Cancer ◽  
Group A ◽  
Group B ◽  
Line Chemotherapy

313 Background: Previous data suggested that LDH serum levels may be associated with tumour hypoxia and VEGFA and VEGFR-1 over-expression. LDH may then represent an indirect marker of activated tumour neo-angiogenesis and worse prognosis in many tumour types. In our analysis, we analyzed the role of LDH serum levels in predicting clinical outcome for biliary tract cancer patients treated with first-line cisplatin and gemcitabine chemotherapy, to individuate a potentially reliable and easy to use marker for patients stratification. Methods: 71 advanced biliary tract cancer patients treated with cisplatin and gemcitabine in first-line chemotherapy were available for our analysis. For all patients, LDH values were collected within one month before treatment beginning. We chose the laboratory cut-off (Upper Normal Rate, UNR) as LDH cut-off value (450 U/l) and then we divided the patients into two groups (A and B, below and above the UNR respectively). Survival distribution was estimated by the Kaplan-Meier method. Disease control rate (DCR) was assessed with chi-square test. A significant level of 0.05 was chosen to assess the statistical significance. Results: Patients in group A (46 patients) and B (25 patients) proved homogeneous for all clinical characteristics analyzed. Median progression free survival (PFS) was 3.97 months and 1.8 months respectively in group A (patients with LDH level below the UNR) and in group B (patients with LDH level above the UNR), p=0.0064 (HR=2.07, 95%CI: 1.07-3.99). Median overall survival (OS) was 9.24 months and 2.55 months in group A and B respectively, p<0.0001 (HR=2.93; 95%CI: 1.37-6.27). DCR was 65% in group A vs. 21% in group B (p=0.004). Conclusions: Our observations seem to suggest a prognostic role of LDH in biliary tract cancer patients. Our findings showing an improved PFS and DCR in patients with low LDH serum levels also suggest a possible predictive role in patients treated with a cisplatin and gemcitabine regimen as first-line chemotherapy. After further confirmation in larger trial, these results may be relevant for a better patients stratification and selection.

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