Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation

2019 ◽  
Vol 23 (7) ◽  
pp. 898-907 ◽  
Author(s):  
Toru Fujii ◽  
Hiroko Segawa ◽  
Ai Hanazaki ◽  
Shiori Nishiguchi ◽  
Sakura Minoshima ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Phosphate Transporter ◽  
Phosphorylation Sites ◽  
Hormone Regulation ◽  
Sodium Dependent

Role of the sodium-dependent phosphate transporter PIT1 in bone growth in vivo

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S107
Author(s):  
A. Bourgine ◽  
P. Pilet ◽  
S. Diouani ◽  
S. Sourice ◽  
J. Lesoeur ◽  
...  
Keyword(s):  
Bone Growth ◽  
Phosphate Transporter ◽  
Sodium Dependent

scholarly journals Phosphate Transporter Regulator That Prevents Abnormal Hyperphosphatemia.

2021 ◽  
Author(s):  
Sumire Sasaki ◽  
Yuji Shiozaki ◽  
Ai Hanazaki ◽  
Megumi Koike ◽  
Kazuya Tanifuji ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Inorganic Phosphate ◽  
Fibroblast Growth Factor 23 ◽  
Kidney Injury ◽  
Proximal Tubules ◽  
Type Ii ◽  
Fibroblast Growth ◽  
Sodium Dependent ◽  
Fgf23 Concentration

Abstract Renal type II sodium-dependent inorganic phosphate (Pi) transporters NaPi2a and NaPi2c cooperate with other organs to strictly regulate the plasma Pi concentration. A high Pi load induces the phosphaturic hormones parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23), enhances urinary Pi excretion and prevents the onset of hyperphosphatemia. How FGF23 is induced from the bones by a high Pi load and the setpoint of the plasma Pi concentration, however, are unclear. Here, we investigated the role of transporter-associated protein (TRAP), found in gene co-expression networks in NaPi2a and NaPi2c function. TRAP is localized in the renal proximal tubules and interacts with NaPi2a. In TRAP-knockout (KO) mice, the serum FGF23 concentration was markedly increased but increased Pi excretion and hypophosphatemia were not observed. In addition, TRAP-KO mice exhibit reduced NaPi2a responsiveness to FGF23 and PTH administration. Furthermore, a dietary Pi load causes marked hyperphosphatemia and abnormal NaPi2a regulation in TRAP-KO mice. Thus, TRAP is thought to be associated with FGF23 induction in bones and the regulation of NaPi2a to prevent an increase in the plasma Pi concentration due to a high Pi load and kidney injury.

scholarly journals The Role of Sodium-Dependent Phosphate Transporter in Phosphate Homeostasis

2015 ◽  
Vol 61 (Supplement) ◽  
pp. S119-S121 ◽  
Author(s):  
Hiroko SEGAWA ◽  
Yuji SHIOZAKI ◽  
Ichiro KANEKO ◽  
Ken-ichi MIYAMOTO
Keyword(s):  
Phosphate Transporter ◽  
Phosphate Homeostasis ◽  
Sodium Dependent

Type 1 Sodium-Dependent Phosphate Transporter acts as a Membrane Potential-Driven Urate Exporter

2013 ◽  
Vol 6 (2) ◽  
pp. 88-94 ◽  
Author(s):  
Takaaki Miyaji ◽  
Tatsuya Kawasaki ◽  
Natsuko Togawa ◽  
Hiroshi Omote ◽  
Yoshinori Moriyama
Keyword(s):  
Membrane Potential ◽  
Phosphate Transporter ◽  
Sodium Dependent
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