Functional in situ assessment of human articular cartilage using MRI: a whole-knee joint loading device

2017 ◽  
Vol 16 (6) ◽  
pp. 1971-1986 ◽  
Author(s):  
Sven Nebelung ◽  
Manuel Post ◽  
Stefan Raith ◽  
Horst Fischer ◽  
Matthias Knobe ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Human Articular Cartilage ◽  
Joint Loading ◽  
Loading Device ◽  
In Situ Assessment ◽  
Knee Joint Loading

scholarly journals Model predictions of increased knee joint loading in regions of thinner articular cartilage after patellar tendon adhesion

2011 ◽  
Vol 29 (8) ◽  
pp. 1168-1177 ◽  
Author(s):  
Justin W. Fernandez ◽  
Massoud Akbarshahi ◽  
Kay M. Crossley ◽  
Kevin B. Shelburne ◽  
Marcus G. Pandy
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Patellar Tendon ◽  
Joint Loading ◽  
Model Predictions ◽  
Knee Joint Loading

scholarly journals Versican gene expression in human articular cartilage and comparison of mRNA splicing variation with aggrecan

1993 ◽  
Vol 291 (2) ◽  
pp. 361-367 ◽  
Author(s):  
J Grover ◽  
P J Roughley
Keyword(s):  
Alternative Splicing ◽  
Articular Cartilage ◽  
Regulatory Protein ◽  
Mrna Splicing ◽  
Human Articular Cartilage ◽  
Complement Regulatory Protein ◽  
Mature Adult ◽  
Epidermal Growth ◽  
Egf Domain

The chondrocytes in human articular cartilage from subjects of all ages express mRNAs for both of the aggregating proteoglycans aggrecan and versican, although the level of expression of versican mRNA is much lower than that of aggrecan mRNA. Aggrecan shows alternative splicing of the epidermal growth factor (EGF)-like domain within its C-terminal globular region, but there is no evidence for a major difference in situ in the relative expression of this domain with age. At all ages studied from birth to the mature adult, a greater proportion of transcripts lacked the EGF domain. The relative proportions of the two transcripts did not change upon culture and passage of isolated chondrocytes. In contrast, the neighbouring complement regulatory protein (CRP)-like domain was predominantly expressed irrespective of age, but cell culture did result in variation of the splicing of this domain. Versican possesses two EGF-like domains and one CRP-like domain, but at all ages the three domains were predominantly present in all transcripts. This situation persisted upon culture and passage of the chondrocytes. Thus, unlike aggrecan, the versican expressed by human articular cartilage does not appear to undergo alternative splicing of its C-terminal globular region, either in cartilage in situ or in chondrocytes in culture.

Influence of rearfoot kinematics during initial ground contact on knee joint loading in rearfoot running

2011 ◽  
Vol 3 (sup1) ◽  
pp. S78-S79
Author(s):  
Frank Ingo Michel ◽  
Sebastian Campe ◽  
Eveline Silvia Graf ◽  
Katja Johanna Michel
Keyword(s):  
Knee Joint ◽  
Ground Contact ◽  
Joint Loading ◽  
Knee Joint Loading
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