scholarly journals Lung Nodule Classification Using Biomarkers, Volumetric Radiomics, and 3D CNNs

Author(s):  
Kushal Mehta ◽  
Arshita Jain ◽  
Jayalakshmi Mangalagiri ◽  
Sumeet Menon ◽  
Phuong Nguyen ◽  
...  

AbstractWe present a hybrid algorithm to estimate lung nodule malignancy that combines imaging biomarkers from Radiologist’s annotation with image classification of CT scans. Our algorithm employs a 3D Convolutional Neural Network (CNN) as well as a Random Forest in order to combine CT imagery with biomarker annotation and volumetric radiomic features. We analyze and compare the performance of the algorithm using only imagery, only biomarkers, combined imagery + biomarkers, combined imagery + volumetric radiomic features, and finally the combination of imagery + biomarkers + volumetric features in order to classify the suspicion level of nodule malignancy. The National Cancer Institute (NCI) Lung Image Database Consortium (LIDC) IDRI dataset is used to train and evaluate the classification task. We show that the incorporation of semi-supervised learning by means of K-Nearest-Neighbors (KNN) can increase the available training sample size of the LIDC-IDRI, thereby further improving the accuracy of malignancy estimation of most of the models tested although there is no significant improvement with the use of KNN semi-supervised learning if image classification with CNNs and volumetric features is combined with descriptive biomarkers. Unexpectedly, we also show that a model using image biomarkers alone is more accurate than one that combines biomarkers with volumetric radiomics, 3D CNNs, and semi-supervised learning. We discuss the possibility that this result may be influenced by cognitive bias in LIDC-IDRI because malignancy estimates were recorded by the same radiologist panel as biomarkers, as well as future work to incorporate pathology information over a subset of study participants.

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
Rab Nawaz Jadoon ◽  
Waqas Jadoon ◽  
Ahmad Khan ◽  
Zia ur Rehman ◽  
Sajid Shah ◽  
...  

In this paper, we propose a linear discriminative learning model called adaptive locality-based weighted collaborative representation (ALWCR) that formulates the image classification task as an optimization problem to reduce the reconstruction error between the query sample and its computed linear representation. The optimal linear representation for a query image is obtained by using the weighted regularized linear regression approach which incorporates intrinsic locality structure and feature variance between data into representation. The resultant representation increases the discrimination ability for correct classification. The proposed ALWCR method can be considered an extension of the collaborative representation- (CR-) based classification approach which is an alternative to the sparse representation- (SR-) based classification method. ALWCR improved the discriminant ability for classification as compared with CR original formulation and overcomes the limitations that arose due to a small training sample size and low feature dimension. Experimental results obtained using various feature dimensions on well-known publicly available face and digit datasets have verified the competitiveness of the proposed method against competing image classification methods.


Mathematics ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 779
Author(s):  
Ruriko Yoshida

A tropical ball is a ball defined by the tropical metric over the tropical projective torus. In this paper we show several properties of tropical balls over the tropical projective torus and also over the space of phylogenetic trees with a given set of leaf labels. Then we discuss its application to the K nearest neighbors (KNN) algorithm, a supervised learning method used to classify a high-dimensional vector into given categories by looking at a ball centered at the vector, which contains K vectors in the space.


2021 ◽  
Vol 2021 (4) ◽  
Author(s):  
Jack Y. Araz ◽  
Michael Spannowsky

Abstract Ensemble learning is a technique where multiple component learners are combined through a protocol. We propose an Ensemble Neural Network (ENN) that uses the combined latent-feature space of multiple neural network classifiers to improve the representation of the network hypothesis. We apply this approach to construct an ENN from Convolutional and Recurrent Neural Networks to discriminate top-quark jets from QCD jets. Such ENN provides the flexibility to improve the classification beyond simple prediction combining methods by linking different sources of error correlations, hence improving the representation between data and hypothesis. In combination with Bayesian techniques, we show that it can reduce epistemic uncertainties and the entropy of the hypothesis by simultaneously exploiting various kinematic correlations of the system, which also makes the network less susceptible to a limitation in training sample size.


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