Cervical cancer tissue characterized by high-resolution magic angle spinning MR spectroscopy

2004 ◽  
Vol 16 (4) ◽  
pp. 174-181 ◽  
Author(s):  
Beathe Sitter ◽  
Tone Bathen ◽  
Bj� �rn Hagen ◽  
Cecilie Arentz ◽  
Finn Egil Skjeldestad ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
High Resolution ◽  
Mr Spectroscopy ◽  
Magic Angle Spinning ◽  
Cancer Tissue ◽  
Magic Angle ◽  
Cervical Cancer Tissue ◽  
Angle Spinning

scholarly journals Evaluation of Tissue Metabolites with High Resolution Magic Angle Spinning MR Spectroscopy Human Prostate Samples after Three-Year Storage at –80 °C

2007 ◽  
Vol 2 ◽  
pp. 117727190700200 ◽  
Author(s):  
Kate W. Jordan ◽  
Wenlei He ◽  
Elkan F. Halpern ◽  
Chin-Lee Wu ◽  
Leo L. Cheng
Keyword(s):  
High Resolution ◽  
Mr Spectroscopy ◽  
Frozen Storage ◽  
Storage Conditions ◽  
Magic Angle Spinning ◽  
Human Prostate ◽  
Magic Angle ◽  
Metabolic Degradation ◽  
Specific Tissue ◽  
Angle Spinning

Accurate interpretation and correlation of tissue spectroscopy with pathological conditions requires disease-specific tissue metabolite databases; however, specimens for research are often kept in frozen storage for various lengths of time. Whether such frozen storage results in alterations to the measured metabolites is a critical but largely unknown issue. In this study, human prostate tissues from specimens that had been stored at –80 °C for 32 months were analyzed with high resolution magic angle spinning (HRMAS) magnetic resonance (MR) spectroscopy, and compared with the initial measurements of the adjacent specimens from the same cases when snap frozen in the operation room and kept frozen for less than 24 hours. Results of the current study indicate that that the storage-induced metabolite alterations are below the limits that tissue MR spectroscopy can discriminate. Furthermore, quantitative pathology evaluations suggest the observed alterations in metabolite profiles measured from the adjacent specimens of the same prostates may be accounted for by tissue pathological heterogeneities and are not a result of storage conditions. Hence, these results indicate that long-term frozen storage of prostate specimens can be quantitatively analyzed by HRMAS MR spectroscopy without concerns regarding significant metabolic degradation or alteration.

Prediction of survival for patients with advanced colorectal cancer using1H High-resolution magic angle spinning nuclear MR spectroscopy

2014 ◽  
Vol 41 (6) ◽  
pp. 1669-1674 ◽  
Author(s):  
Barbara Pacholczyk-Sienicka ◽  
Anna Fabiańska ◽  
Grażyna Pasz-Walczak ◽  
Radzisław Kordek ◽  
Stefan Jankowski
Keyword(s):  
Colorectal Cancer ◽  
High Resolution ◽  
Mr Spectroscopy ◽  
Advanced Colorectal Cancer ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Prediction Of Survival ◽  
Angle Spinning

High-resolution magic angle spinning MRS of breast cancer tissue

2002 ◽  
Vol 15 (5) ◽  
pp. 327-337 ◽  
Author(s):  
Beathe Sitter ◽  
Ursula Sonnewald ◽  
Manfred Spraul ◽  
Hans E. Fjösne ◽  
Ingrid S. Gribbestad
Keyword(s):  
Breast Cancer ◽  
High Resolution ◽  
Magic Angle Spinning ◽  
Breast Cancer Tissue ◽  
Cancer Tissue ◽  
Magic Angle ◽  
Angle Spinning

High Resolution Magic Angle Spinning NMR in Combinatorial Chemistry

2001 ◽  
Vol 4 (4) ◽  
pp. 333-351 ◽  
Author(s):  
G. Lippens ◽  
R. Warrass ◽  
J. Wieruszeski ◽  
P. Rousselot-Pailley ◽  
G. Chessari
Keyword(s):  
High Resolution ◽  
Combinatorial Chemistry ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Angle Spinning

A Polystyrene-Supported Tin Trichloride Catalyst with a C11-Spacer. Catalysis Monitoring Using High-Resolution Magic Angle Spinning NMR

2007 ◽  
Vol 26 (27) ◽  
pp. 6718-6725 ◽  
Author(s):  
Vanja Pinoie ◽  
Kevin Poelmans ◽  
Hans E. Miltner ◽  
Ingrid Verbruggen ◽  
Monique Biesemans ◽  
...  
Keyword(s):  
High Resolution ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Angle Spinning
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