scholarly journals Comparison of multi-delay FAIR and pCASL labeling approaches for renal perfusion quantification at 3T MRI

2019 ◽  
Vol 33 (1) ◽  
pp. 81-94 ◽  
Author(s):  
Anita A. Harteveld ◽  
Anneloes de Boer ◽  
Suzanne Lisa Franklin ◽  
Tim Leiner ◽  
Marijn van Stralen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Renal Perfusion ◽  
Intra Class Correlation ◽  
3T Mri ◽  
Perfusion Measurement ◽  
Arterial Transit Time ◽  
Perfusion Quantification ◽  
Intra Class Correlation Coefficient

Abstract Objective To compare the most commonly used labeling approaches, flow-sensitive alternating inversion recovery (FAIR) and pseudocontinuous arterial spin labeling (pCASL), for renal perfusion measurement using arterial spin labeling (ASL) MRI. Methods Multi-delay FAIR and pCASL were performed in 16 middle-aged healthy volunteers on two different occasions at 3T. Relative perfusion-weighted signal (PWS), temporal SNR (tSNR), renal blood flow (RBF), and arterial transit time (ATT) were calculated for the cortex and medulla in both kidneys. Bland–Altman plots, intra-class correlation coefficient, and within-subject coefficient of variation were used to assess reliability and agreement between measurements. Results For the first visit, RBF was 362 ± 57 and 140 ± 47 mL/min/100 g, and ATT was 0.47 ± 0.13 and 0.70 ± 0.10 s in cortex and medulla, respectively, using FAIR; RBF was 201 ± 72 and 84 ± 27 mL/min/100 g, and ATT was 0.71 ± 0.25 and 0.86 ± 0.12 s in cortex and medulla, respectively, using pCASL. For both labeling approaches, RBF and ATT values were not significantly different between visits. Overall, FAIR showed higher PWS and tSNR. Moreover, repeatability of perfusion parameters was better using FAIR. Discussion This study showed that compared to (balanced) pCASL, FAIR perfusion values were significantly higher and more comparable between visits.

Arterial spin labeling magnetic resonance imaging at short post-labeling delay reflects cerebral perfusion pressure verified by oxygen-15-positron emission tomography in cerebrovascular steno-occlusive disease

2020 ◽  
pp. 028418512091711
Author(s):  
Hiroshi Itagaki ◽  
Yasuaki Kokubo ◽  
Kanako Kawanami ◽  
Shinji Sato ◽  
Yuki Yamada ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Arterial Spin Labeling ◽  
Cerebral Perfusion ◽  
Perfusion Pressure ◽  
Spin Labeling ◽  
Occlusive Disease ◽  
Resonance Imaging ◽  
Arterial Transit Time ◽  
The Right

Background Arterial transit time correction by data acquisition with multiple post-labeling delays (PLDs) or relatively long PLDs is expected to obtain more accurate imaging in cases of the cerebrovascular steno-occlusive disease. However, there have so far been no reports describing the significance of arterial spin labeling (ASL) images at short PLDs regarding the evaluation of cerebral circulation in ischemic cerebrovascular disease. Purpose To clarify the role of short-PLD ASL in cerebrovascular steno-occlusive disease. Material and Methods Fifty-three patients with cerebrovascular steno-occlusive disease were included in this study. All patients underwent ASL magnetic resonance imaging and 15O-PET within two days of each modality. To compare the ASL findings with each parameter of PET, the right-to-left (R/L) ratio, defined as the right middle cerebral artery (MCA) value/left MCA value, was calculated. Results There is a significant correlation between the ASL images at a short PLD and the ratio of cerebral blood flow and cerebral blood volume by 15O-PET, which may accurately reflect the cerebral perfusion pressure. A receiver operating characteristic curve analysis indicated that ASL images at PLD 1000 and 1500 ms were more accurate than at PLD 2000–3000 ms for the detection of a ≥10% change in the PET cerebral blood flow. Conclusion ASL images at shorter PLDs may be useful at least as a screening modality to detect the changes in the cerebral circulation in cerebrovascular steno-occlusive disease. We must evaluate ASL images at multiple PLDs while considering the arterial transit time of each case at present.

scholarly journals The spatial coefficient of variation in arterial spin labeling cerebral blood flow images

2017 ◽  
Vol 37 (9) ◽  
pp. 3184-3192 ◽  
Author(s):  
Henri JMM Mutsaerts ◽  
Jan Petr ◽  
Lena Václavů ◽  
Jan W van Dalen ◽  
Andrew D Robertson ◽  
...  
Keyword(s):  
Blood Flow ◽  
Spatial Distribution ◽  
Cerebral Blood Flow ◽  
Coefficient Of Variation ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Maximum Relative Error ◽  
Signal Distribution ◽  
Arterial Transit Time ◽  
Age And Sex

Macro-vascular artifacts are a common arterial spin labeling (ASL) finding in populations with prolonged arterial transit time (ATT) and result in vascular regions with spuriously increased cerebral blood flow (CBF) and tissue regions with spuriously decreased CBF. This study investigates whether there is an association between the spatial signal distribution of a single post-label delay ASL CBF image and ATT. In 186 elderly with hypertension (46% male, 77.4 ± 2.5 years), we evaluated associations between the spatial coefficient of variation (CoV) of a CBF image and ATT. The spatial CoV and ATT metrics were subsequently evaluated with respect to their associations with age and sex – two demographics known to influence perfusion. Bland–Altman plots showed that spatial CoV predicted ATT with a maximum relative error of 7.6%. Spatial CoV was associated with age (β = 0.163, p = 0.028) and sex (β = −0.204, p = 0.004). The spatial distribution of the ASL signal on a standard CBF image can be used to infer between-participant ATT differences. In the absence of ATT mapping, the spatial CoV may be useful for the clinical interpretation of ASL in patients with cerebrovascular pathology that leads to prolonged transit of the ASL signal to tissue.

scholarly journals Noninvasive Renal Perfusion Measurement Using Arterial Spin Labeling (ASL) MRI: Basic Concept

2021 ◽  
pp. 229-239
Author(s):  
Min-Chi Ku ◽  
María A. Fernández-Seara ◽  
Frank Kober ◽  
Thoralf Niendorf
Keyword(s):  
Basic Concept ◽  
Arterial Spin Labeling ◽  
Regional Distribution ◽  
Spin Labeling ◽  
Renal Perfusion ◽  
The European Union ◽  
Perfusion Measurement ◽  
Metabolic Products ◽  
Renal Mri ◽  
The Cost

AbstractThe kidney is a complex organ involved in the excretion of metabolic products as well as the regulation of body fluids, osmolarity, and homeostatic status. These functions are influenced in large part by alterations in the regional distribution of blood flow between the renal cortex and medulla. Renal perfusion is therefore a key determinant of glomerular filtration. Therefore the quantification of regional renal perfusion could provide important insights into renal function and renal (patho)physiology. Arterial spin labeling (ASL) based perfusion MRI techniques, can offer a noninvasive and reproducible way of measuring renal perfusion in animal models. This chapter addresses the basic concept of ASL-MRI.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.

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