scholarly journals Chondrogenesis and Integration of Mesenchymal Stem Cells Within an In Vitro Cartilage Defect Repair Model

2009 ◽  
Vol 37 (12) ◽  
pp. 2556-2565 ◽  
Author(s):  
T. Vinardell ◽  
S. D. Thorpe ◽  
C. T. Buckley ◽  
D. J. Kelly
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cartilage Defect ◽  
Cartilage Defect Repair ◽  
Defect Repair

Sox11-modified mesenchymal stem cells accelerate cartilage defect repair in SD rats

2019 ◽  
Vol 376 (2) ◽  
pp. 247-255 ◽  
Author(s):  
Liangliang Xu ◽  
E Shunmei ◽  
Sien Lin ◽  
Yonghui Hou ◽  
Weiping Lin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cartilage Defect ◽  
Sd Rats ◽  
Cartilage Defect Repair ◽  
Defect Repair

Combined Effects of Bone Marrow-Derived Mesenchymal Stem Cells and PLGA-PEG-PLGA Scaffolds on Repair of Articular Cartilage Defect

2013 ◽  
Vol 815 ◽  
pp. 345-349 ◽  
Author(s):  
Ching Wen Hsu ◽  
Ping Liu ◽  
Song Song Zhu ◽  
Feng Deng ◽  
Bi Zhang
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Growth Factor ◽  
Cartilage Defect ◽  
Cartilage Regeneration ◽  
Tissue Growth ◽  
Cartilage Defects

Here we reported a combined technique for articular cartilage repair, consisting of bone arrow mesenchymal stem cells (BMMSCs) and poly (dl-lactide-co-glycolide-b-ethylene glycol-b-dl-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers carried with tissue growth factor (TGF-belat1). In the present study, BMMSCs seeded on PLGA-PEG-PLGA with were incubated in vitro, carried or not TGF-belta1, Then the effects of the composite on repair of cartilage defect were evaluated in rabbit knee joints in vivo. Full-thickness cartilage defects (diameter: 5 mm; depth: 3 mm) in the patellar groove were either left empty (n=18), implanted with BMMSCs/PLGA (n=18), TGF-belta1 modified BMMSCs/PLGA-PEG-PLGA. The defect area was examined grossly, histologically at 6, 24 weeks postoperatively. After implantation, the BMMSCs /PLGA-PEG-PLGA with TGF-belta1 group showed successful hyaline-like cartilage regeneration similar to normal cartilage, which was superior to the other groups using gross examination, qualitative and quantitative histology. These findings suggested that a combination of BMMSCs/PLGA-PEG-PLGA carried with tissue growth factor (TGF-belat1) may be an alternative treatment for large osteochondral defects in high loading sites.

Scaffold-Free, Engineered Porcine Cartilage Construct for Cartilage Defect Repair—In Vitro and In Vivo Study

2006 ◽  
Vol 30 (8) ◽  
pp. 586-596 ◽  
Author(s):  
Kwideok Park ◽  
Jinsong Huang ◽  
Frederick Azar ◽  
Ri L. Jin ◽  
Byoung-Hyun Min ◽  
...  
Keyword(s):  
Cartilage Defect ◽  
In Vivo Study ◽  
Cartilage Defect Repair ◽  
Defect Repair ◽  
Cartilage Construct

scholarly journals BMP-12 Treatment of Adult Mesenchymal Stem Cells In Vitro Augments Tendon-Like Tissue Formation and Defect Repair In Vivo

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e17531 ◽  
Author(s):  
Jonathan Y. Lee ◽  
Zuping Zhou ◽  
Peter J. Taub ◽  
Melissa Ramcharan ◽  
Yonghui Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tissue Formation ◽  
Adult Mesenchymal Stem Cells ◽  
Defect Repair
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