p53 acetylation enhances Taxol-induced apoptosis in human cancer cells

APOPTOSIS ◽  
2012 ◽  
Vol 18 (1) ◽  
pp. 110-120 ◽  
Author(s):  
Jae Hyeong Kim ◽  
Eun-Kyung Yoon ◽  
Hye-Jin Chung ◽  
Seong-Yeol Park ◽  
Kyeong-Man Hong ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Induced Apoptosis

scholarly journals RuvBL1 Maintains Resistance to TRAIL-Induced Apoptosis by Suppressing c-Jun/AP-1 Activity in Non-Small Cell Lung Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Hao Li ◽  
Taoran Zhou ◽  
Yue Zhang ◽  
Hengyi Jiang ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Therapeutic Strategy ◽  
Molecular Mechanisms ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
The Common ◽  
Trail Resistance ◽  
Induced Apoptosis ◽  
Necrosis Factor

Lung cancer is the common malignant tumor with the highest death rate in the world. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a potential anticancer agent induces selective apoptotic death of human cancer cells. Unfortunately, approximately half of lung cancer cell lines are intrinsically resistant to TRAIL-induced cell death. In this study, we identified RuvBL1 as a repressor of c-Jun/AP-1 activity, contributing to TRAIL resistance in lung cancer cells. Knocking down RuvBL1 effectively sensitized resistant cells to TRAIL, and overexpression of RuvBL1 inhibited TRAIL-induced apoptosis. Moreover, there was a negative correlation expression between RuvBL1 and c-Jun in lung adenocarcinoma by Oncomine analyses. High expression of RuvBL1 inversely with low c-Jun in lung cancer was associated with a poor overall prognosis. Taken together, our studies broaden the molecular mechanisms of TRAIL resistance and suggest the application of silencing RuvBL1 synergized with TRAIL to be a novel therapeutic strategy in lung cancer treatment.

scholarly journals Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells

2008 ◽  
Vol 75 (10) ◽  
pp. 2020-2033 ◽  
Author(s):  
Dae-Hee Lee ◽  
Clifford Kim ◽  
Lin Zhang ◽  
Yong J. Lee
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Induced Apoptosis

scholarly journals Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells

Autophagy ◽  
2012 ◽  
Vol 8 (3) ◽  
pp. 338-349 ◽  
Author(s):  
Jing Zhou ◽  
Shuai-Er Hu ◽  
Shi-Hao Tan ◽  
Ruoxi Cao ◽  
Yiyang Chen ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Induced Apoptosis

scholarly journals ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21(CIP1/WAF1)in human cancer cells

2014 ◽  
Vol 171 (13) ◽  
pp. 3182-3195 ◽  
Author(s):  
Jingru Li ◽  
Yicheng Chen ◽  
Jiali Wan ◽  
Xin Liu ◽  
Chunrong Yu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Induced Apoptosis

Changes in intracellular Ca2+ concentrations related to PDT-induced apoptosis in photosensitized human cancer cells

1998 ◽  
Vol 128 (2) ◽  
pp. 205-210 ◽  
Author(s):  
Hisao Tajiri ◽  
Akemi Hayakawa ◽  
Yoshinari Matsumoto ◽  
Itsuo Yokoyama ◽  
Shigeaki Yoshida
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Induced Apoptosis
Sign in / Sign up

Export Citation Format

Share Document