Change of viral hemorrhagic septicemia virus (VHSV) titer in olive flounder (Paralichthys olivaceus) following Poly(I:C) administration

2013 ◽  
Vol 22 (3) ◽  
pp. 1175-1179 ◽  
Author(s):  
Wi-Sik Kim ◽  
Jong-Oh Kim ◽  
Jae-Kwon Cho ◽  
Myung-Joo Oh
Keyword(s):  
Paralichthys Olivaceus ◽  
Olive Flounder ◽  
Poly I:C ◽  
Viral Hemorrhagic Septicemia Virus ◽  
Viral Hemorrhagic Septicemia ◽  
Olive Flounder Paralichthys Olivaceus

scholarly journals Poly (I:C)-Potentiated Vaccination Enhances T Cell Response in Olive Flounder (Paralichthys olivaceus) Providing Protection against Viral Hemorrhagic Septicemia Virus (VHSV)

Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 482
Author(s):  
Jin Hong Chun ◽  
Jae Wook Jung ◽  
Young Rim Kim ◽  
Jassy Mary S. Lazarte ◽  
Si Won Kim ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Paralichthys Olivaceus ◽  
T Cell Responses ◽  
Olive Flounder ◽  
Poly I:C ◽  
Viral Hemorrhagic Septicemia Virus ◽  
Cell Responses ◽  
Viral Hemorrhagic Septicemia ◽  
Olive Flounder Paralichthys Olivaceus

Viral hemorrhagic septicemia (VHS), caused by viral hemorrhagic septicemia virus (VHSV), is a viral disease affecting teleosts, and is the major cause of virus-related deaths in olive flounder (Paralichthys olivaceus). Research has focused on ways to control VHS, and recently, the use of polyinosinic-polycytidylic acid poly (I:C)-potentiated vaccination has been investigated, whereby fish are injected with poly (I:C) and then with live pathogenic virus, resulting in a significant decrease in VHSV-related mortality. T cell responses were investigated in the present study after vaccinating olive flounder with poly (I:C)-potentiated vaccination to understand the ability of poly (I:C) to induce T cell immunity. Stimulation of T cell responses with the poly (I:C)-potentiated vaccination was confirmed by examining levels of CD3+ T cells, CD4-1+ T cells and CD4-2+ T cells. Higher levels of CD4-2+ T cells were found in vaccinated fish than CD4-1+ T cells, believed to result from a synergistic effect between poly (I:C) administration and pathogenic VHSV immunization. More importantly, the role of CD4-2+ T cells in the antiviral response was clearly evident. The results of this study suggest that the outstanding protection obtained with the poly (I:C)-potentiated vaccination is due to the robust immune response initiated by the CD4-2+ T cells.

Sign in / Sign up

Export Citation Format

Share Document