Effect of Proton Pump Inhibitors on the Secretion of Bicarbonates and Pepsinogen Induced by Chemical Stimulation of the Gastric Mucosa

2013 ◽  
Vol 154 (4) ◽  
pp. 415-418
Author(s):  
V. A. Zolotarev ◽  
R. P. Khropycheva
Keyword(s):  
Gastric Mucosa ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Chemical Stimulation ◽  
Stimulation Of

scholarly journals CHARACTERISTICS OF GASTRIC MUCOSA INJURY IN PATIENTS WITH NSAID-INDUCED GASTROPATHY AND CONCOMITANT ISCHEMIC HEART DISEASE, AND WAYS TO CORRECT THIS CONDITION

2020 ◽  
Vol 20 (2) ◽  
pp. 70-75
Author(s):  
V.V. Parkhomenko ◽  
І.М. Skrypnyk ◽  
І.І. Starchenko ◽  
O.F. Gopko
Keyword(s):  
Heart Disease ◽  
Gastric Mucosa ◽  
Ischemic Heart Disease ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Morphological Changes ◽  
Ischemic Heart ◽  
Mucosal Barrier ◽  
Nsaid Gastropathy ◽  
H Pylori

The non-steroidal anti-inflammatory drugs (NSAIDs) in general clinical practice can provoke the development of NSAID-induced gastropathy, which can be complicated by bleeding. The aim of this article was to evaluate the effect of eupatilin on histological changes of the gastric mucosa in patients with NSAID-induced gastropathy and concomitant ischemic heart disease depending on the association with Helicobacter pylori. The study included 125 patients with NSAID-gastropathy and concomitant stable ischemic heart disease I-II functional class. Patients were divided into two groups: I (n=82) included individuals with NSAID-gastropathy, which was not associated with H. pylori, while II (n=43) included individuals with H. pylori-induced gastropathy. Depending on the prescribed treatment complexes, patients were subdivided as follows: I-A (n=44) included patients, who took proton pump inhibitors in standard doses and II-A group (n=23) included patients, who received antihelicobacter therapy according to Maastricht V (2016) guidelines. Patients of groups I-B (n=38) and II-B (n=20) were additionally prescribed 60 mg of eupatilin (1 tablet) 3 times a day for 28 days. The upper endoscopy with the gastric mucosa biopsy, followed by histological examination was done at the beginning of treatment and in 45±2 days. The severity of gastric mucosa erosive and ulcerative injury was assessed endoscopically using a modified Lanzascore scale; morphological changes were evaluated by a semi-quantitative method on a visual-analogue scale. H. pylori is an independent and significant factor determining the severity of endoscopic and morphological changes in NSAID-gastropathy patients with concomitant ischemic heart disease. Acid-suppressive and antihelicobacter therapy can reduce the intensity of the structural injury of the gastric mucosa, but the identified changes substantiate the feasibility of long-term proton pump inhibitors prescribed to the patients with NSAID-gastropathy. Prescribing eupatilin against the background of basic therapy can significantly reduce the severity of erosive-ulcerative gastric mucosa injury assessed by Lanzascore scale while histomorphological parameters by reducing the activity of neutrophilic inflammation, protective effect on mucosal barrier resistance and microcirculatory condition.

Proton pump inhibitors are gastric mucosa carbonic anhydrase inhibitors as well

2001 ◽  
Vol 120 (5) ◽  
pp. A156-A156
Author(s):  
I PUSCAS ◽  
L GILAU ◽  
M COLTAU ◽  
A MAGHIAR ◽  
G DOMUTA ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Carbonic Anhydrase ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Carbonic Anhydrase Inhibitors

Proton pump inhibitors are gastric mucosa carbonic anhydrase inhibitors as well

2001 ◽  
Vol 120 (5) ◽  
pp. A156
Author(s):  
Ioan Puscas ◽  
Ludovic Gilau ◽  
Marcela Coltau ◽  
Adrian Maghiar ◽  
Gabriela Domuta ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Carbonic Anhydrase ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Carbonic Anhydrase Inhibitors

Proton pump inhibitors protect gastric mucosa from aspirin-induced injuries in parallel with carbonic anhydrase inhibition

2000 ◽  
Vol 118 (4) ◽  
pp. A1296
Author(s):  
Ioan Puscas ◽  
Marcela Coltau ◽  
Ioan I. Puscas ◽  
Adrian Maghiar ◽  
Ioan Herea ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Carbonic Anhydrase ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Carbonic Anhydrase Inhibition

scholarly journals REGULARITY OF CHANGES IN THE LEVEL OF ACIDITY, HELICOBACTER INFECTION AND CLINICAL MANIFESTATIONS IN THE FORM OF HEARTBURN IN PATIENTS WITH CHRONIC NON-ATROPHIC GASTRITIS BEFORE AND AFTER TREATMENT WITHOUT USE OF PROTON PUMP INHIBITORS

2021 ◽  
Vol 19 (4) ◽  
Author(s):  
A.A. Avramenko
Keyword(s):  
Gastric Mucosa ◽  
Atrophic Gastritis ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Clinical Manifestations ◽  
Average Level ◽  
Comparative Characteristic ◽  
Urease Test ◽  
Before And After ◽  
H Pylori

The aim of the work – to study the regularity of changes in the level of acidity, H.pylori infection and the clinical manifestation of heartburn in patients with chronic nonatrophic gastritis before and after treatment that did not include proton pump inhibitors.Material and methods. We have analyzed the results of a comprehensive examinationof 38 patients with chronic non-atrophic gastritis, suffering from heartburn, before andafter treatment that did not include proton pump inhibitors. Comprehensive examinationbefore treatment included a step-by-step pH-metry, esophagogastroduodenoscopy,double testing for Helicobacter pylori infection (urease test and microscopy of the stainedsmears-prints) using mucosal biopsy specimens from 4 topographic zones of the stomach;histological examination of the gastric mucosa, material for which was taken from thesame areas, and HELIC test. After the treatment, pH-meter control and HELIС test wereperformed.Results. When carrying out a comparative characteristic of the obtained data, ithasbeen found that the average level of acidity after the treatment increased from moderateminimal hypoacidity to pronounced absolute hyperacidity, while the average level ofcontamination of the gastric mucosa by H. pylori infection, tracked by the level of theHELIC test, decreased from 16.4 ± 0.12 mm to 2.3 ± 0.12 mm, and the "heartburn"symptom disappeared in 100% of cases.Conclusions. In the formation of the “heartburn”symptom in patients with chronicnon-atrophic gastritis, the leading factor is the level of ammonia produced by H. pyloriinfection.

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