The Use of Autologous Mesenchymal Stem Cells for Cell Therapy of Patients with Amyotrophic Lateral Sclerosis in Belarus

2015 ◽  
Vol 159 (4) ◽  
pp. 576-581 ◽  
Author(s):  
Yu. N. Rushkevich ◽  
S. M. Kosmacheva ◽  
G. V. Zabrodets ◽  
S. I. Ignatenko ◽  
N. V. Goncharova ◽  
...  
Keyword(s):  
Stem Cells ◽  
Amyotrophic Lateral Sclerosis ◽  
Mesenchymal Stem Cells ◽  
Cell Therapy ◽  
Autologous Mesenchymal Stem Cells ◽  
Lateral Sclerosis

Selection of optimal passage of bone marrow-derived mesenchymal stem cells for stem cell therapy in patients with amyotrophic lateral sclerosis

2010 ◽  
Vol 472 (2) ◽  
pp. 94-98 ◽  
Author(s):  
Mi Ran Choi ◽  
Hyun Young Kim ◽  
Ji-Yoon Park ◽  
Tae Yong Lee ◽  
Cheong Soon Baik ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Amyotrophic Lateral Sclerosis ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Lateral Sclerosis ◽  
Selection Of

scholarly journals Autologous Mesenchymal Stem Cells for the Treatment of Amyotrophic Lateral Sclerosis

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Jorge C Trainini ◽  
Gabriel Volman ◽  
Noemi Lago ◽  
Javier Bordone ◽  
Oscar Ectchegoyen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Amyotrophic Lateral Sclerosis ◽  
Mesenchymal Stem Cells ◽  
Autologous Mesenchymal Stem Cells ◽  
Lateral Sclerosis

Autologous mesenchymal stem cells: clinical applications in amyotrophic lateral sclerosis

2006 ◽  
Vol 28 (5) ◽  
pp. 523-526 ◽  
Author(s):  
Letizia Mazzini ◽  
Katia Mareschi ◽  
Ivana Ferrero ◽  
Elena Vassallo ◽  
Giuseppe Oliveri ◽  
...  
Keyword(s):  
Stem Cells ◽  
Amyotrophic Lateral Sclerosis ◽  
Mesenchymal Stem Cells ◽  
Clinical Applications ◽  
Autologous Mesenchymal Stem Cells ◽  
Lateral Sclerosis

Intravenous infusion of mesenchymal stem cells delays disease progression in the SOD1G93A transgenic amyotrophic lateral sclerosis rat model

2021 ◽  
Vol 1757 ◽  
pp. 147296
Author(s):  
Hirotoshi Magota ◽  
Masanori Sasaki ◽  
Yuko Kataoka-Sasaki ◽  
Shinichi Oka ◽  
Ryo Ukai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Amyotrophic Lateral Sclerosis ◽  
Mesenchymal Stem Cells ◽  
Disease Progression ◽  
Rat Model ◽  
Intravenous Infusion ◽  
Lateral Sclerosis

Mesenchymal Stem Cells in the Treatment of Amyotrophic Lateral Sclerosis

2016 ◽  
Vol 11 (1) ◽  
pp. 41-50 ◽  
Author(s):  
Mahsa Hajivalili ◽  
Fatemeh Pourgholi ◽  
Hossein Samadi Kafil ◽  
Farhad Jadidi-Niaragh ◽  
Mehdi Yousefi
Keyword(s):  
Stem Cells ◽  
Amyotrophic Lateral Sclerosis ◽  
Mesenchymal Stem Cells ◽  
Lateral Sclerosis

scholarly journals Autologous mesenchymal stem cells in treatment of liver cirrhosis: evaluation of effectiveness and visualization method

2020 ◽  
Vol 5 (3) ◽  
pp. 197-203
Author(s):  
Inna E. Kotkas ◽  
Natella I. Enukashvili ◽  
Shamil M. Asadulayev ◽  
Anna V. Chubar
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Cirrhosis ◽  
Cell Therapy ◽  
Clinical Observation ◽  
Health Assessment ◽  
Subjective Health ◽  
Oxide Nanoparticles ◽  
Cell Structures ◽  
Autologous Mesenchymal Stem Cells

Through clinical observation, we present an assessment of the autologous mesenchymal stem cells effectiveness in treatment of liver cirrhosis of alimentary etiology. In order to determine the localization of the implanted cell structures, the stem cells were previously labeled with iron (II, III) oxide nanoparticles (IONPs). Further MRI visualization helped to detect the cell structures stained with iron oxide nanoparticles in the human body. In 6 months after the cell therapy, the patient underwent clinical and biochemical blood tests, MEGX test, elastography and subjective health assessment test. The tests data analysis revealed the improvement of the values of all examined parameters after the cell treatment. Also in 6 and 12 months after the treatment, a liver biopsy was performed from the area where the implanted stem cells were visualized. In histological examination of liver bioptates obtained from the area of MSC transplantation, the largest number of stained cells was observed in liver micronodes, as well as at the boundaries of micronodes and fibrous septa. A portion of the bioptate obtained in 12 months after transplantation was used to produce primary cell cultures. Before the first re-seeding of the cultures, cell colonies of both fibroblast-like morphology and epithelial were detected in them. Both types of colonies contained the particles. Conducting the cell therapy to a patient with liver cirrhosis of alimentary etiology contributed to improving the laboratory and instrumental examinations indicators. The patient had come through the treatment procedure satisfactorily, no complications were registered.

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