Analysis of Morphological Changes in the CNS and Internal Organs of Macaca mulatta Monkeys after Intracerebral Injection of a Low-Attenuated Rubella Virus Strain

2021 ◽  
Vol 171 (5) ◽  
pp. 671-675
Author(s):  
O. A. Shamsutdinova ◽  
D. V. Bulgin ◽  
D. D. Karal-Ogly ◽  
I. N. Lavrent’eva
Diagnostics ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 682
Author(s):  
Gelsomina Mansueto ◽  
Mario Di Napoli ◽  
Pasquale Mascolo ◽  
Anna Carfora ◽  
Pierluca Zangani ◽  
...  

Background: Diagnostic criteria for electrocution related death are still a challenge in forensic pathology and it seems that the electrical mark is the only reliable evidence. Methods: A comparison of histological and morphological findings of skin and internal organs from an autopsy series of electrocution deaths with those mostly reported in literature as representative for electrocution. Results: The morphological changes of heart, brain and other main internal organs are still unspecific. Organ’s damage observed in electrocution deaths shows a wide variability, not reliable for a certain diagnosis of electrocution. The electrical mark is still the golden standard for diagnosis of electrocution. Conclusions: In electrocution related deaths, pathological findings of the main internal organs are not enough evidence to support with certainty a post-mortem diagnosis that a victim suffered an electrical damage. Although the organ histological changes are undoubtedly the starting point for a better understanding of the fatal even, the diagnosis of death from electrical damage is still a dark and unsolved chapter. The electrical mark still represents a fundamental indicator above all in the medical-legal field, but the identification of pathognomonic elements and signs not limited to the skin alone could be a valid help in the future, especially in unclear cases.


Intervirology ◽  
1993 ◽  
Vol 36 (4) ◽  
pp. 225-236 ◽  
Author(s):  
J.K. Chantler ◽  
K.D. Lund ◽  
N.P.H. Miki ◽  
C.A. Berkowitz ◽  
G. Tai

Intervirology ◽  
2003 ◽  
Vol 46 (2) ◽  
pp. 79-85 ◽  
Author(s):  
Zhiyu Wang ◽  
Ping Yao ◽  
Yanyan Song ◽  
Guiting Wang ◽  
Yongkang Wang ◽  
...  

Author(s):  
Nikita Aleksandrovich Navolokin ◽  
◽  
Olga Viktorovna Matveeva ◽  
Galina Nikiforovna Maslyakova ◽  
Alla Borisovna Bucharskaya ◽  
...  

Author(s):  
Alla Borisovna Bucharskaya ◽  
◽  
Georgiy Sergeevich Terentyuk ◽  
Galina Nikiphorovna Maslyakova ◽  
Olga Viktorovna Matveeva ◽  
...  

Author(s):  
G. M. Ignatev ◽  
E. V. Atrashevskaya ◽  
L. L. Suchanova ◽  
E. S. Sidorenko ◽  
N. A. Netesova

Aim. In order to study rubella virus strain RA-27/3 genetic stability, used for the vaccines production, a molecular genetic study was conducted. Materials and methods. In the study different series of master and work seed of RA-27/3 rubella virus strain by «Microgen», a few lots of rubella vaccines by the different manufacturers, as well as strain «Orlov» of rubella virus were used. RT-PCR followed by restriction, sequencing were performed . Results. Full-genomic sequences of the rubella virus strain RA-27/3 by «Microgen», were obtained and presented to GenBank. The full structure correspondence of RA-27/3 rubella virus strain by «Microgen» to the similar rubella strains used by GSK and Merck & Co Inc. has been shown. The RT-PCR method with the subsequent restriction was fulfilled using only domestic reagents. The developed method has been demonstrated as applicable for the identification of the RA-27/3 rubella virus strain as in monopreparation as well as in the combined vaccine preparation. Conclusion. The data obtained make it possible to suggest application of the molecular genetic methods for the vaccine virus identification not only at the production stages, but also in the finished vaccine lots.


2021 ◽  
Vol 12 (4) ◽  
pp. 34-45
Author(s):  
N. K. Arutiunova ◽  
L. V. Araslanova ◽  
V. A. Riabchenko ◽  
E. A. Pisarenko ◽  
E. I. Ter-Ananiants

Abnormalities of the abdominal aorta branches may cause chronic mesenteric ischemia, progressive pathological changes of the internal organs in this setting, and chronic pain syndrome. The causes of chronic mesenteric ischemia may be divided into atherosclerotic and non-atherosclerotic. Atherosclerosis of the unpaired branches of the abdominal aorta involves stenosis or occlusion. Other causes include fibromuscular dysplasia, vasculitis (Takayasu, segmental mediolytic arteriopathy), and median arcuate ligament syndrome. These syndromes, the pathogenesis of some of which remains controversial, lead to nonspecific complaints such as abdominal pain, weight loss, and others. Digital subtraction angiography or duplex ultrasound may provide hemodynamic information in cases of vascular disease in this area. However, multislice spiral computed tomography is in many cases the first choice because it allows for a comprehensive assessment of the state of blood vessels and associated morphological changes of internal organs. Structural changes accompanying these syndromes can also occur in patients who are undergoing a medical examination for other reasons. However, these syndromes should not be diagnosed solely on the basis of imaging; instead, the findings should be compared with the clinical presentation, which implies collaboration of radiologists and clinicians.


Author(s):  
А. А. Babanin ◽  
V. S. Ulanov

The experiment with the chronic effects of alcohol on experimental animals reflects the picture of long-term use of alcoholic beverages by a person with alcoholism. It is impossible to fully study the ultrastructural changes in internal organs, including the reproductive system, in humans, both in acute and chronic alcohol consumption, but the results obtained in the experiment can be extrapolated to humans. The results obtained showed that changes in the parenchymal-stromal elements of the testicles during chronic alcoholization are reduced to dystrophic transformation of the spermatogenic epithelium. The testicular stroma is characterized by pronounced circulatory disorders with plethora and stasis in the postcapillaries and small veins, edema, phenomena of perivascular and interstitial sclerosis, with foci of pronounced hyalinosis, most expressed by 2-3 months of alcoholism. By 6 months of the model experiment, there was no dynamics of the growth of morphological changes, partial adaptation to constant intoxication with ethyl alcohol.


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