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F1000Research ◽  
2022 ◽  
Vol 11 ◽  
pp. 34
Author(s):  
Ricardo Aparecido Pereira ◽  
Albimara Hey ◽  
Alexandre Lustoza de Carli ◽  
Camila Garcia Salvador Sanches ◽  
Jardel Cristiano Bordion ◽  
...  

Background: Oxidative stress and the mild inflammatory process present in diabetes play a critical role in the pathogenesis of the disease and its comorbidities. This understanding has opened new avenues and targets for developing improved treatments since the risk factors associated with diabetes may be reduced through non-pharmacological interventions. In this sense, plant extracts could be efficient in preventing or assisting these pathological conditions treatment. Methods: Diabetes mellitus was induced in 24 rats, which were allocated in 4 groups: Control (CT), Control+Baccharis (CT-B), Diabetes (DB), and Diabetes+Baccharis (DB-B). For 28 days, the animals of CT-B and DB-B groups were treated, via gavage, with B. dracunculifolia extract at 50 mg.kg-1. Results: The DB group presented higher values than the DB-B group on parameters such as creatinine (26.42%), urea (31.42%), and triglycerides (60.80%). Creatinine and triglycerides values of DB-B group (0.39±0.01 e 75.0±8.4, receptively) were equivalent to the values of CT group (0.32±0.01 e 71.7±5.4) and of CT-B group (0.39±0.01, and 58.8±4.5). The treatment with B. dracunculifolia improved the levels of fasting glucose and response of glucose tolerance (32%), insulin (52,17%) and lipid peroxidation (liver 33.33%, kidney 38.77%) when compared to the DB group. Conclusions: The phenolic compounds and the anti-inflammatory activity of the extract of Baccharis dracunculifolia may be responsible for the hypoglycemic effect observed in the study.


2022 ◽  
Vol 19 (1) ◽  
Author(s):  
Alexander T. Clark ◽  
Eric E. Abrahamson ◽  
Matthew M. Harper ◽  
Milos D. Ikonomovic

Abstract Background Altered cerebrovascular function and accumulation of amyloid-β (Aβ) after traumatic brain injury (TBI) can contribute to chronic neuropathology and increase the risk for Alzheimer’s disease (AD). TBI due to a blast-induced shock wave (bTBI) adversely affects the neurovascular unit (NVU) during the acute period after injury. However, the chronic effects of bTBI and Aβ on cellular components of the NVU and capillary network are not well understood. Methods We exposed young adult (age range: 76–106 days) female transgenic (Tg) APP/PS1 mice, a model of AD-like Aβ amyloidosis, and wild type (Wt) mice to a single bTBI (~ 138 kPa or ~ 20 psi) or to a Sham procedure. At 3-months or 12-months survival after exposure, we quantified neocortical Aβ load in Tg mice, and percent contact area between aquaporin-4 (AQP4)-immunoreactive astrocytic end-feet and brain capillaries, numbers of PDGFRβ-immunoreactive pericytes, and capillary densities in both genotypes. Results The astroglia AQP4-capillary contact area in the Tg-bTBI group was significantly lower than in the Tg-Sham group at 3-months survival. No significant changes in the AQP4-capillary contact area were observed in the Tg-bTBI group at 12-months survival or in the Wt groups. Capillary density in the Tg-bTBI group at 12-months survival was significantly higher compared to the Tg-Sham control and to the Tg-bTBI 3-months survival group. The Wt-bTBI group had significantly lower capillary density and pericyte numbers at 12-months survival compared to 3-months survival. When pericytes were quantified relative to capillary density, no significant differences were detected among the experimental groups, for both genotypes. Conclusion In conditions of high brain concentrations of human Aβ, bTBI exposure results in reduced AQP4 expression at the astroglia-microvascular interface, and in chronic capillary proliferation like what has been reported in AD. Long term microvascular changes after bTBI may contribute to the risk for developing chronic neurodegenerative disease later in life.


2022 ◽  
Vol 11 ◽  
Author(s):  
Hai-ni Wen ◽  
Chen-yu Wang ◽  
Jin-meng Li ◽  
Zheng Jiao

The cardiotoxicity of anti-cancer drugs presents as a challenge to both clinicians and patients. Significant advances in cancer treatments have improved patient survival rates, but have also led to the chronic effects of anti-cancer therapies becoming more prominent. Additionally, it is difficult to clinically predict the occurrence of cardiovascular toxicities given that they can be transient or irreversible, with large between-subject variabilities. Further, cardiotoxicities present a range of different symptoms and pathophysiological mechanisms. These notwithstanding, mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) modeling offers an important approach to predict cardiotoxicities and offering precise cardio-oncological care. Efforts have been made to integrate the structures of physiological and pharmacological networks into PK-PD modeling to the end of predicting cardiotoxicities based on clinical evaluation as well as individual variabilities, such as protein expression, and physiological changes under different disease states. Thus, this review aims to report recent progress in the use of PK-PD modeling to predict cardiovascular toxicities, as well as its application in anti-cancer therapies.


Author(s):  
Handan Karaoglu

Within the scope of this research, the chronic effects of ammonium nitrate, which is the most widely used fertilizer worldwide, on the tadpoles of Marsh Frog (Pelophylax ridibundus), the Iranian Long-Legged Frog (Rana macrocnemis), the Caucasian Parsley Frog (Pelodytes caucasicus) and the Variable Green Toad (Bufotes variabilis) were examined. To assess the chronic effects of the fertilizer, the tadpoles of all the species were exposed to 0, 5, 10, 15, 20, 25 mg/L concentrations in same conditions. The chronic concentrations were applied from the 25th developmental stage to the 42nd developmental stage. It was defined at the end of the experiments that although there were some variability between different populations of the same species or between different species in the observed effects, chronic levels of ammonium nitrate caused decreased growth rate, prolonging in time to complete metamorphosis, increased abnormalities, and mortality in general. Among the 4 amphibian species, the Variable Green Toad was the most damaged one in terms of growth reduction (on average 31-41 %), abnormality rates (on average 50-75 %), prolonged time to complete metamorphose (14-21 days on average) and mortality rates (%54-100). The most adaptive species and the least damaged one was an Iranian long-legged frog for growth reduction (on average 0-15 %), prolonged time to complete metamorphose (7-9 days on average), and mortality rates (%9-15). All the harmful effects of chronic fertilizer levels caused by agricultural activities in the region had very important for examined species in our researches and it can be said that important environmental and biodiversity problems may occur if certain precautions are not taken regarding the use of the fertilizers and if the attitudes of the farmers on this issue cannot be changed.


Muscles ◽  
2022 ◽  
Vol 1 (1) ◽  
pp. 1-15
Author(s):  
Irismar G. A. Encarnação ◽  
Ricardo B. Viana ◽  
Saulo R. S. Soares ◽  
Eduardo D. S. Freitas ◽  
Claudio A. B. de Lira ◽  
...  

A detraining period after resistance training causes a significant decrease in trained-induced muscular adaptations. However, it is unclear how long muscle strength and hypertrophy gains last after different detraining periods. Thus, the present systematic review with meta-analysis aimed to evaluate the chronic effects of detraining on muscle strength and hypertrophy induced by resistance training. Searches were conducted on PubMed, Scopus, EBSCO, CINAHL, CENTRAL, and Web of Science. The difference in means and pooled standard deviations of outcomes were converted into Hedges’ g effect sizes (g). Twenty randomized and non-randomized trials (high and moderate risks of bias, respectively, and fair quality) were included for qualitative analysis of muscle strength and hypertrophy, while only two studies were included in the meta-analysis for maximum muscle strength. The resistance training group presented a significant increase in one-repetition maximum (1RM) chest press (g: 4.43 [3.65; 5.22], p < 0.001) and 1RM leg press strength (g: 4.47 [2.12; 6.82], p < 0.001) after training. The strength gains observed in the resistance training group were also maintained after 16–24 weeks of detraining (g: 1.99 [0.62; 3.36], p = 0.004; and g: 3.16 [0.82; 5.50], p = 0.008; respectively), when compared to the non-exercise control group. However, 1RM chest press and leg press strength level was similar between groups after 32 (g: 1.81 [−0.59; 4.21], p = 0.139; and g: 2.34 [−0.48; 5.16], p = 0.104; respectively) and 48 weeks of detraining (g: 1.01 [−0.76; 2.79], p = 0.263; and g: 1.16 [−1.09; 3.42], p = 0.311; respectively). There was not enough data to conduct a meta-analysis on muscular hypertrophy. In conclusion, the present systematic review and meta-analysis demonstrated that, when taking random error into account, there is no sufficient high-quality evidence to make any unbiased claim about how long changes in muscle strength induced by RT last after a DT period. Moreover, the effect of different DT periods on muscle hypertrophy induced by RT remains unknown since there was not enough data to conduct a meta-analysis with this variable.


Author(s):  
Andrea Soltysova ◽  
Patricia Begerova ◽  
Kristina Jakic ◽  
Katarina Kozics ◽  
Monika Sramkova ◽  
...  

AbstractThe unique physicochemical properties make inorganic nanoparticles (INPs) an exciting tool in diagnosis and disease management. However, as INPs are relatively difficult to fully degrade and excrete, their unintended accumulation in the tissue might result in adverse health effects. Herein, we provide a methylome–transcriptome framework for chronic effects of INPs, commonly used in biomedical applications, in human kidney TH-1 cells. Renal clearance is one of the most important routes of nanoparticle excretion; therefore, a detailed evaluation of nanoparticle-mediated nephrotoxicity is an important task. Integrated analysis of methylome and transcriptome changes induced by INPs (PEG-AuNPs, Fe3O4NPs, SiO2NPs, and TiO2NPs) revealed significantly deregulated genes with functional classification in immune response, DNA damage, and cancer-related pathways. Although most deregulated genes were unique to individual INPs, a relatively high proportion of them encoded the transcription factors. Interestingly, FOS hypermethylation inversely correlating with gene expression was associated with all INPs exposures. Our study emphasizes the need for a more comprehensive investigation of INPs’ biological safety, especially after chronic exposure. Graphical abstract


2021 ◽  
Author(s):  
S.V. Ermolaeva

The main goal of health risk analysis is to obtain and generalize information about the possible influence of environmental factors on human health. As a result of hydrochemical analysis of drinking water supply sources in the Ulyanovsk region, a list of main contaminants has been established. It includes ammonium, iron, copper, phosphates, sulfates, chlorides, nitrates, zinc, manganese and chromium. Among them three pollutants - iron, manganese and sulfates – had surpassed maximum permissible concentration. The concentration of iron at the level of threshold chronic effects was found in drinking water of Baryshsky (0.13), Melekessky (0.16), Sengileevsky (0.13) districts. Severe chronic effects can be caused by the concentration of iron and manganese in the drinking water of the Staromainsky (0.4 and 0.3) and Cherdaklinsky (0.9 and 0.27) districts. Assessment of health risks led us to the conclusion that drinking water can serve as an additional risk factor and provoke disease development. Key words: risk factors, morbidity, maximum permissible concentration, pollutants, relative conditional risk, average daily dose.


2021 ◽  
Vol 1 (2) ◽  
pp. 46-52
Author(s):  
Dewi S. Soemarko ◽  
Firly Ratsmita

There are several risk factors associated with the incidence of chronic lymphocytic leukaemia (CLL), namely genetic factors, smoking, and occupational exposure to chemicals. We highlight a possible association of a CLL case and the occupational. We reported a case of CLL patient, a 69-year-old man, who had been working as a vegetable seller and a chili farmer since 15 and 4 years ago, respectively. The patient was diagnosed with CLL three months prior to admission and had a history of three times blood transfusions. The patient only complained of paleness and weakness without any specific symptoms. No swelling of the lymph nodes, hepatomegaly, or splenomegaly was found. As a vegetable seller and chili farmer, the patient was exposed to five hazards, physical, chemical, biological, ergonomic to psychosocial. Therefore, it is necessary to analyse whether there was an association between the patient's work and the current CLL. To diagnose occupational diseases, several steps are needed. In this patient, one of the risk factors that could lead to CLL was exposure to chemicals such as pesticides. However, information regarding the content of pesticides used was unclear and there were no results obtained from pesticides biomarker examination that might cause the disease, making it difficult to establish a definitive diagnosis of work-related cause. The patient could be advised to have biomarkers of pesticide substances checked, which requires control of farmers and vegetable sellers who might have been exposed to pesticides. The control mechanism might be started from elimination, substitution, engineering, administration, and use of personal protective equipment. A control mechanism is necessary to prevent the entry of contaminants into the body, especially through inhalation, oral, and dermal pathways. It is recommended to examine for biomarkers of pesticides containing organophosphates, organochlorines, or carbamates to determine the chronic effects on the accumulation of these chemicals that might cause CLL.


Author(s):  
Jonathan A. Robbins ◽  
Karsten Menzel ◽  
Michael Lassman ◽  
Tian Zhao ◽  
Craig Fancourt ◽  
...  

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