scholarly journals Are Voluntary Wheel Running and Open-Field Behavior Correlated in Mice? Different Answers from Comparative and Artificial Selection Approaches

2012 ◽  
Vol 42 (5) ◽  
pp. 830-844 ◽  
Author(s):  
Vincent Careau ◽  
Olaf R. P. Bininda-Emonds ◽  
Genesis Ordonez ◽  
Theodore Garland
Keyword(s):  
Open Field ◽  
Artificial Selection ◽  
Wheel Running ◽  
Open Field Behavior ◽  
Voluntary Wheel Running ◽  
Field Behavior ◽  
Voluntary Wheel

502 OPEN-FIELD BEHAVIOR AND GABA RECEPTOR DENSITY AFTER SPONTANEOUS WHEEL RUNNING AND TREADMILL TRAINING

1993 ◽  
Vol 25 (Supplement) ◽  
pp. S90 ◽  
Author(s):  
S. D. Youngstedt ◽  
R. K. Dishman FACSM ◽  
A. L. Dunn ◽  
M. A. Wilson ◽  
S. P. Wilson
Keyword(s):  
Open Field ◽  
Gaba Receptor ◽  
Wheel Running ◽  
Treadmill Training ◽  
Receptor Density ◽  
Open Field Behavior ◽  
Field Behavior

scholarly journals Artificial Selection for Increased Voluntary Wheel Running Alters Limb Skeleton Shape and Exercise Plasticity in Mice

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Amanda N Smolinsky ◽  
Kristina Aldridge ◽  
Alberto A Castro ◽  
Theodore Garland ◽  
Kevin M Middleton
Keyword(s):  
Artificial Selection ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Selection For ◽  
Voluntary Wheel

Artificial selection for increased wheel-running activity in house mice results in decreased body mass at maturity

1999 ◽  
Vol 202 (18) ◽  
pp. 2513-2520 ◽  
Author(s):  
J.G. Swallow ◽  
P. Koteja ◽  
P.A. Carter ◽  
T. Garland
Keyword(s):  
Genetic Correlation ◽  
Body Mass ◽  
Artificial Selection ◽  
Wheel Running ◽  
House Mice ◽  
Selected Lines ◽  
Voluntary Wheel Running ◽  
Running Activity ◽  
Wheel Running Activity ◽  
Voluntary Wheel

To test the hypothesis that body size and activity levels are negatively genetically correlated, we conducted an artificial selection experiment for increased voluntary wheel-running activity in house mice (Mus domesticus). Here, we compare body masses of mice from control and selected lines after 14 generations of selection. In both groups, beginning at weaning and then for 8 weeks, we housed half of the individuals with access to running wheels that were free to rotate and the other half with wheels that were locked to prevent rotation. Mice from selected lines were more active than controls at weaning (21 days) and across the experiment (total revolutions during last week: females 2.5-fold higher, males 2.1-fold higher). At weaning, mice from selected and control lines did not differ significantly in body mass. At 79 days of age, mice from selected lines weighed 13.6 % less than mice from control lines, whereas mice with access to free wheels weighed 4.5 % less than ‘sedentary’ individuals; both effects were statistically significant and additive. Within the free-wheel-access group, individual variation in body mass of males was negatively correlated with amount of wheel-running during the last week (P<0.01); for females, the relationship was also negative but not statistically significant (P>0.40). The narrow-sense genetic correlation between wheel-running and body mass after 8 weeks of wheel access was estimated to be −0. 50. A negative genetic correlation could account for the negative relationship between voluntary wheel-running and body mass that has been reported across 13 species of muroid rodents.

scholarly journals Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice

2021 ◽  
Author(s):  
S.E. Hamm ◽  
D.D. Fathalikhani ◽  
K.E. Bukovec ◽  
A.K. Addington ◽  
H. Zhang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Muscle Function ◽  
Wheel Running ◽  
Mdx Mice ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

Membrane Estrogen Receptors Regulate Voluntary Wheel Running and Contractile Function in Skeletal Muscle in Mice

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 781
Author(s):  
Jacqueline M. Crissey ◽  
J. Andries Ferreira ◽  
Dennis B. Lubahn ◽  
Marybeth Brown
Keyword(s):  
Skeletal Muscle ◽  
Estrogen Receptors ◽  
Wheel Running ◽  
Contractile Function ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel
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