White Matter Integrity Following Traumatic Brain Injury: The Association with Severity of Injury and Cognitive Functioning

2013 ◽  
Vol 26 (4) ◽  
pp. 648-660 ◽  
Author(s):  
Gershon Spitz ◽  
Jerome J. Maller ◽  
Richard O’Sullivan ◽  
Jennie L. Ponsford
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Cognitive Functioning ◽  
White Matter Integrity ◽  
Severity Of Injury

Moderate–severe traumatic brain injury causes delayed loss of white matter integrity: Evidence of fornix deterioration in the chronic stage of injury

Brain Injury ◽  
2013 ◽  
Vol 27 (12) ◽  
pp. 1415-1422 ◽  
Author(s):  
Areeba Adnan ◽  
Adrian Crawley ◽  
David Mikulis ◽  
Morris Moscovitch ◽  
Brenda Colella ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Severe Traumatic Brain Injury ◽  
White Matter Integrity ◽  
Chronic Stage ◽  
Injury Causes

Whole brain white matter integrity measures on patients with moderate to severe traumatic brain injury (TBI). FA and entropy analysis

2016 ◽  
Vol 32 ◽  
pp. 250
Author(s):  
Charalambos Yiannakkaras ◽  
Nikos Konstantinou ◽  
Eva Pettemeridou ◽  
Fofi Constantinidou ◽  
Eleni Eracleous ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Severe Traumatic Brain Injury ◽  
White Matter Integrity ◽  
Entropy Analysis ◽  
Whole Brain ◽  
Brain White Matter

Apathetic symptoms and white matter integrity after traumatic brain injury

Brain Injury ◽  
2021 ◽  
pp. 1-11
Author(s):  
Blanca Navarro-Main ◽  
Ana Castaño-León ◽  
Amaya Hilario ◽  
Alfonso Lagares Gómez- Abascal ◽  
Jose Periañez ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
White Matter Integrity

An investigation of white matter integrity and attention deficits following traumatic brain injury

Brain Injury ◽  
2018 ◽  
Vol 32 (6) ◽  
pp. 776-783 ◽  
Author(s):  
Jacqueline Anne Owens ◽  
Gershon Spitz ◽  
Jennie Louise Ponsford ◽  
Alicia Rhian Dymowski ◽  
Catherine Willmott
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Attention Deficits ◽  
White Matter Integrity

Diffusion Tensor Imaging (DTI) Based Measures of White Matter Integrity After Traumatic Brain Injury

2018 ◽  
Vol 99 (11) ◽  
pp. e133
Author(s):  
Andrei Vakhtin ◽  
Ansgar Furst ◽  
Dana Waltzman ◽  
J. Ashford ◽  
Max Wintermark ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Diffusion Tensor Imaging ◽  
Brain Injury ◽  
White Matter ◽  
Diffusion Tensor ◽  
White Matter Integrity ◽  
Diffusion Tensor Imaging Dti

scholarly journals Cognitive Training in Young Patients With Traumatic Brain Injury: A Fixel-Based Analysis

2019 ◽  
Vol 33 (10) ◽  
pp. 813-824 ◽  
Author(s):  
Helena Verhelst ◽  
Diana Giraldo ◽  
Catharine Vander Linden ◽  
Guy Vingerhoets ◽  
Ben Jeurissen ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Cognitive Functioning ◽  
Cognitive Training ◽  
Cognitive Assessment ◽  
Cognitive Intervention ◽  
The Body ◽  
Precentral Gyrus ◽  
Time Point

Background. Traumatic brain injury (TBI) is associated with altered white matter organization and impaired cognitive functioning. Objective. We aimed to investigate changes in white matter and cognitive functioning following computerized cognitive training. Methods. Sixteen adolescents with moderate-to-severe TBI (age 15.6 ± 1.8 years, 1.2-4.6 years postinjury) completed the 8-week BrainGames program and diffusion weighted imaging (DWI) and cognitive assessment at time point 1 (before training) and time point 2 (after training). Sixteen healthy controls (HC) (age 15.6 ± 1.8 years) completed DWI assessment at time point 1 and cognitive assessment at time point 1 and 2. Fixel-based analyses were used to examine fractional anisotropy (FA), mean diffusivity (MD), and fiber cross-section (FC) on a whole brain level and in tracts of interest. Results. Patients with TBI showed cognitive impairments and extensive areas with decreased FA and increased MD together with an increase in FC in the body of the corpus callosum and left superior longitudinal fasciculus (SLF) at time point 1. Patients improved significantly on the inhibition measure at time point 2, whereas the HC group remained unchanged. No training-induced changes were observed on the group level in diffusion metrics. Exploratory correlations were found between improvements on verbal working memory and reduced MD of the left SLF and between increased performance on an information processing speed task and increased FA of the right precentral gyrus. Conclusions. Results are indicative of positive effects of BrainGames on cognitive functioning and provide preliminary evidence for neuroplasticity associated with cognitive improvements following cognitive intervention in TBI.

scholarly journals Frontostriatal White Matter Integrity Relations with “Cool” and “Hot” Self-Regulation after Pediatric Traumatic Brain Injury

2021 ◽  
Vol 38 (1) ◽  
pp. 122-132
Author(s):  
Jesse T. Fischer ◽  
Paul T. Cirino ◽  
Dana DeMaster ◽  
Candice Alfano ◽  
Johanna Bick ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Self Regulation ◽  
White Matter Integrity ◽  
Pediatric Traumatic Brain Injury

scholarly journals Diffuse disconnectivity in traumatic brain injury: a resting state fMRI and DTI study

2012 ◽  
Vol 3 (1) ◽  
Author(s):  
Cheuk Tang ◽  
Emily Eaves ◽  
Kristen Dams-O’Connor ◽  
Lap Ho ◽  
Eric Leung ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Default Mode Network ◽  
Resting State ◽  
Axonal Injury ◽  
White Matter Integrity ◽  
White Matter Tracts ◽  
Imaging Protocol ◽  
Default Mode

AbstractDiffuse axonal injury is a common pathological consequence of Traumatic Brain Injury (TBI). Diffusion Tensor Imaging is an ideal technique to study white matter integrity using the Fractional Anisotropy (FA) index which is a measure of axonal integrity and coherence. There have been several reports showing reduced FA in individuals with TBI, which suggest demyelination or reduced fiber density in white matter tracts secondary to injury. Individuals with TBI are usually diagnosed with cognitive deficits such as reduced attention span, memory and executive function. In this study we sought to investigate correlations between brain functional networks, white matter integrity, and TBI severity in individuals with TBI ranging from mild to severe. A resting state functional magnetic resonance imaging protocol was used to study the default mode network in subjects at rest. FA values were decreased throughout all white matter tracts in the mild to severe TBI subjects. FA values were also negatively correlated with TBI injury severity ratings. The default mode network showed several brain regions in which connectivity measures were higher among individuals with TBI relative to control subjects. These findings suggest that, subsequent to TBI, the brain may undergo adaptation responses at the cellular level to compensate for functional impairment due to axonal injury.

Correlations Between White Matter Integrity and Motor Function in Traumatic Brain Injury Patients

2011 ◽  
Vol 25 (6) ◽  
pp. 492-502 ◽  
Author(s):  
Karen Caeyenberghs ◽  
Alexander Leemans ◽  
Monique Geurts ◽  
Catharine Vander Linden ◽  
Bouwien C. M. Smits-Engelsman ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Motor Function ◽  
White Matter Integrity
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