scholarly journals Predictors of contralateral prophylactic mastectomy in genetically high risk newly diagnosed breast cancer patients

2020 ◽  
Vol 180 (1) ◽  
pp. 177-185 ◽  
Author(s):  
Mara Tynan ◽  
Beth N. Peshkin ◽  
Claudine Isaacs ◽  
Shawna Willey ◽  
Heiddis B. Valdimarsdottir ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Prophylactic Mastectomy ◽  
Contralateral Prophylactic Mastectomy ◽  
Newly Diagnosed ◽  
Breast Cancer Patients

Quality of Life After Contralateral Prophylactic Mastectomy in Newly Diagnosed High-Risk Breast Cancer Patients Who Underwent BRCA1/2 Gene Testing

2007 ◽  
Vol 25 (3) ◽  
pp. 285-291 ◽  
Author(s):  
Kenneth P. Tercyak ◽  
Beth N. Peshkin ◽  
Barbara M. Brogan ◽  
Tiffani DeMarco ◽  
Marie F. Pennanen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
High Risk ◽  
Cancer Patients ◽  
Prophylactic Mastectomy ◽  
Contralateral Prophylactic Mastectomy ◽  
Breast Cancer Patients ◽  
High Risk Breast Cancer ◽  
Risk Breast Cancer

Purpose Recent studies indicate that high-risk breast cancer patients (ie, women who carry mutations in BRCA1/2 genes) who opt for contralateral prophylactic mastectomy (CPM) have a substantially reduced risk of developing contralateral breast cancer. However, the immediate and long-term impact of this decision on women's quality of life and psychosocial functioning is largely unknown. In this study, we compared the impact of BRCA1/2 genetic test result and CPM on these outcomes among newly diagnosed breast cancer patients who opted for CPM at the time of their definitive surgical treatment versus patients who did not. Patients and Methods Participants were 149 high-risk women who underwent genetic counseling and testing for alterations in the BRCA1/2 genes. We measured self-reported quality of life, cancer-specific distress, and genetic testing–specific distress using standardized instruments before receipt of genetic test results and again 1 and 12 months later. Results Compared with patients who chose breast conservation or unilateral mastectomy, those who chose mastectomy of the affected breast and CPM of the unaffected breast did not report diminished quality of life or elevated distress. Conclusion With respect to quality of life and distress, patients who choose CPM fare as well as those who do not in the first year after surgery.

Contralateral prophylactic mastectomy (CPM) use and utility in New Zealand (NZ) breast cancer patients.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e17671-e17671
Author(s):  
Abbey Jebb ◽  
Ian Campbell ◽  
Rachel Shirley ◽  
Mark Barrios ◽  
David James Porter
Keyword(s):  
Breast Cancer ◽  
New Zealand ◽  
Cancer Patients ◽  
Prophylactic Mastectomy ◽  
Contralateral Prophylactic Mastectomy ◽  
Breast Cancer Patients
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