Effects of PI3K inhibition in AI-resistant breast cancer cell lines: autophagy, apoptosis, and cell cycle progression

2021 ◽  
Author(s):  
Tiago V. Augusto ◽  
Cristina Amaral ◽  
Yuanzhong Wang ◽  
Shiuan Chen ◽  
Cristina F. Almeida ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Cycle Progression ◽  
Breast Cancer Cell Lines ◽  
Cycle Progression ◽  
Pi3k Inhibition ◽  
Resistant Breast Cancer Cell

scholarly journals A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition

2008 ◽  
Vol 415 (1) ◽  
pp. 97-110 ◽  
Author(s):  
Neil E. Torbett ◽  
Antonio Luna-Moran ◽  
Zachary A. Knight ◽  
Andrew Houk ◽  
Mark Moasser ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Therapeutics ◽  
Cancer Cell Lines ◽  
Genetic Alterations ◽  
Breast Cancer Cell Lines ◽  
Selective Inhibitors

The PI3K (phosphoinositide 3-kinase) pathway regulates cell proliferation, survival and migration and is consequently of great interest for targeted cancer therapy. Using a panel of small-molecule PI3K isoform-selective inhibitors in a diverse set of breast cancer cell lines, we have demonstrated that the biochemical and biological responses were highly variable and dependent on the genetic alterations present. p110α inhibitors were generally effective in inhibiting the phosphorylation of PKB (protein kinase B)/Akt and S6, two downstream components of PI3K signalling, in most cell lines examined. In contrast, p110β-selective inhibitors only reduced PKB/Akt phosphorylation in PTEN (phosphatase and tensin homologue deleted on chromosome 10) mutant cell lines, and was associated with a lesser decrease in S6 phosphorylation. PI3K inhibitors reduced cell viability by causing cell-cycle arrest in the G1 phase, with multi-targeted inhibitors causing the most potent effects. Cells expressing mutant Ras were resistant to the cell-cycle effects of PI3K inhibition, which could be reversed using inhibitors of Ras signalling pathways. Taken together, our data indicate that these compounds, alone or in suitable combinations, may be useful as breast cancer therapeutics, when used in appropriate genetic contexts.

scholarly journals Docosahexaenoic acid alters cell death, cancer and cell‐cycle signaling networks in breast cancer cell lines

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Catherine J Field ◽  
Julia B Ewaschuk ◽  
Randy Nelson ◽  
Marnie Newell ◽  
Rene Jacobs
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Death ◽  
Docosahexaenoic Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Signaling Networks ◽  
Breast Cancer Cell Lines ◽  
Cell Cycle Signaling

scholarly journals Overexpression of COX-2 in Celecoxib-Resistant Breast Cancer Cell Lines

2010 ◽  
Vol 163 (2) ◽  
pp. 235-243 ◽  
Author(s):  
Balraj Singh ◽  
LaTashia R. Irving ◽  
Karen Tai ◽  
Anthony Lucci
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Cox 2 ◽  
Resistant Breast Cancer Cell

scholarly journals The Effects of Eribulin on Breast Cancer Microenvironment Identified Using Eribulin-resistant Breast Cancer Cell Lines

2019 ◽  
Vol 39 (8) ◽  
pp. 4031-4041 ◽  
Author(s):  
WATARU GOTO ◽  
SHINICHIRO KASHIWAGI ◽  
YUKA ASANO ◽  
KOJI TAKADA ◽  
KATSUYUKI TAKAHASHI ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Cancer Microenvironment ◽  
Resistant Breast Cancer Cell

scholarly journals Distinct characterization of two vinorelbine-resistant breast cancer cell lines developed by different strategies

2016 ◽  
Vol 35 (4) ◽  
pp. 2355-2363 ◽  
Author(s):  
MINGJIE XU ◽  
DONGHAI JIANG ◽  
JIAYING SHEN ◽  
HUILIN ZHENG ◽  
WEIMIN FAN
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Resistant Breast Cancer Cell

scholarly journals PTEN insufficiency modulates ER+ breast cancer cell cycle progression and increases cell growth in vitro and in vivo

2015 ◽  
pp. 4631 ◽  
Author(s):  
Kun-Chun Chiang ◽  
Chun-Nan Yeh ◽  
Huang-Yang Chen ◽  
Jong-Hwei S.Pang ◽  
Shang-Yu Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Cycle Progression ◽  
Cycle Progression
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