Left ventricular mechanical dyssynchrony analzyed by Tc-99m sestamibi SPECT and F-18 FDG PET in patients with ischemic cardiomyopathy and the prognostic value

2020 ◽  
Vol 36 (10) ◽  
pp. 2063-2071
Author(s):  
Yi Tian ◽  
Min Zhao ◽  
Weilong Li ◽  
Ziwei Zhu ◽  
Hongzhi Mi ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Prognostic Value ◽  
Ischemic Cardiomyopathy ◽  
Mechanical Dyssynchrony ◽  
Left Ventricular ◽  
Left Ventricular Mechanical Dyssynchrony

scholarly journals The assessment of left ventricular mechanical dyssynchrony from gated 99mTc-tetrofosmin SPECT and gated 18F-FDG PET by QGS: a comparative study

2021 ◽  
Author(s):  
Sebastian Lehner ◽  
Frank Philipp Graner ◽  
Maximilian Fischer ◽  
Harun Ilhan ◽  
Peter Bartenstein ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Roc Analysis ◽  
Mechanical Dyssynchrony ◽  
Left Ventricular ◽  
Reference Ranges ◽  
Reference Standard ◽  
99Mtc Tetrofosmin ◽  
Gated Pet ◽  
Significant Difference ◽  
Left Ventricular Mechanical Dyssynchrony

Abstract Background Due to partly conflicting studies, further research is warranted with the QGS software package, with regard to the performance of gated FDG PET phase analysis as compared to gated MPS as well as the establishment of possible cut-off values for FDG PET to define dyssynchrony. Methods Gated MPS and gated FDG PET datasets of 93 patients were analyzed with the QGS software. BW, Phase SD, and Entropy were calculated and compared between the methods. The performance of gated PET to identify dyssynchrony was measured against SPECT as reference standard. ROC analysis was performed to identify the best discriminator of dyssynchrony and to define cut-off values. Results BW and Phase SD differed significantly between the SPECT and PET. There was no significant difference in Entropy with a high linear correlation between methods. There was only moderate agreement between SPECT and PET to identify dyssynchrony. Entropy was the best single PET parameter to predict dyssynchrony with a cut-off point at 62%. Conclusion Gated MPS and gated FDG PET can assess LVMD. The methods cannot be used interchangeably. Establishing reference ranges and cut-off values is difficult due to the lack of an external gold standard. Further prospective research is necessary.

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