Rapid Noninvasive Continuous Monitoring of Oxygenation in Cerebral Ischemia and Hypoxia

2010 ◽  
Vol 10 (4) ◽  
pp. 213-217 ◽  
Author(s):  
John K-J. Li ◽  
Tijun Wang ◽  
Hongjun Zhang
Keyword(s):  
Cerebral Ischemia ◽  
Continuous Monitoring

Continuous monitoring and intervention for cerebral ischemia in tuberculous meningitis

2008 ◽  
Vol 9 (4) ◽  
pp. e25-e30 ◽  
Author(s):  
Anthony A. Figaji ◽  
Simon I. J. Sandler ◽  
A Graham Fieggen ◽  
Peter D. Le Roux ◽  
Jonathan C. Peter ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Tuberculous Meningitis ◽  
Continuous Monitoring

scholarly journals Twenty-four-hour real-time continuous monitoring of acute focal cerebral ischemia in rabbits based on magnetic inductive phase shift

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Shuang-Lin Zhao ◽  
Gui Jin ◽  
Ze-Lin Bai ◽  
Jing-Bo Chen ◽  
Meng-Wei Li ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Cerebral Ischemia ◽  
Phase Shift ◽  
Magnetic Induction ◽  
Continuous Monitoring ◽  
Development Process ◽  
Focal Cerebral Ischemia ◽  
Control Group ◽  
Pathological Development ◽  
Experimental Group

Abstract Background As a serious clinical disease, ischemic stroke is usually detected through magnetic resonance imaging and computed tomography. In this study, a noninvasive, non-contact, real-time continuous monitoring system was constructed on the basis of magnetic induction phase shift (MIPS) technology. The “thrombin induction method”, which conformed to the clinical pathological development process of ischemic stroke, was used to construct an acute focal cerebral ischemia model of rabbits. In the MIPS measurement, a “symmetric cancellation-type” magnetic induction sensor was used to improve the sensitivity and antijamming capability of phase detection. Methods A 24-h MIPS monitoring experiment was carried out on 15 rabbits (10 in the experimental group and five in the control group). Brain tissues were taken from seven rabbits for the 2% triphenyl tetrazolium chloride staining and verification of the animal model. Results The nonparametric independent-sample Wilcoxon rank sum test showed significant differences (p < 0.05) between the experimental group and the control group in MIPS. Results showed that the rabbit MIPS presented a declining trend at first and then an increasing trend in the experimental group, which may reflect the pathological development process of cerebral ischemic stroke. Moreover, TTC staining results showed that the focal cerebral infarction area increased with the development of time Conclusions Our experimental study indicated that the MIPS technology has a potential ability of differentiating the development process of cytotoxic edema from that of vasogenic edema, both of which are caused by cerebral ischemia.

scholarly journals Assessment of Postischemic Cerebral Energy Metabolism in Cat by 31P NMR: The Cumulative Effects of Secondary Hypoxia and Ischemia

1989 ◽  
Vol 9 (4) ◽  
pp. 506-514 ◽  
Author(s):  
J. R. Alger ◽  
A. Brunetti ◽  
G. Nagashima ◽  
K.-A. Hossmann
Keyword(s):  
Energy Metabolism ◽  
Cerebral Ischemia ◽  
Inorganic Phosphate ◽  
Continuous Monitoring ◽  
31P Nmr ◽  
Arterial Occlusion ◽  
Global Cerebral Ischemia ◽  
Cerebral Energy Metabolism ◽  
Cat Model ◽  
Energy Failure

The sensitivity of cerebral energy metabolism to ischemic and hypoxic stresses following global cerebral ischemia was evaluated in a cat model using 31P nuclear magnetic resonance (NMR) spectroscopic methods. Complete global cerebral ischemia of 5 to 10 min in length was produced at 1 h intervals by reversible arterial occlusion, permitting continuous monitoring of NMR and EEG. Ischemia appeared to produce slightly more severe energy failure in animals that had previously experienced an ischemic injury. Preischemic hypoxia (5% O2 for 5 min) resulted in minor changes in the levels of phosphocreatine and intracellular inorganic phosphate, which were slightly amplified in animals that previously experienced ischemia.

Ultrastorcture of Cerebellar Purkinje Cells in Rats Subjected To Partial Global Cerebral Ischemia

1985 ◽  
Vol 43 ◽  
pp. 674-675
Author(s):  
R.V.W. Dimlich ◽  
M.H. Biros
Keyword(s):  
Cerebral Ischemia ◽  
Purkinje Cells ◽  
Cell Types ◽  
Microscopic Level ◽  
Global Cerebral Ischemia ◽  
Light Microscopic Level ◽  
Cerebellar Damage ◽  
Cerebellar Injury ◽  
Cerebellar Purkinje Cells ◽  
Cell Changes

In severe cerebral ischemia, Purkinje cells of the cerebellum are one of the cell types most vulnerable to anoxic damage. In the partial (forebrain) global ischemic (PGI) model of the rat, Paljärvi noted at the light microscopic level that cerebellar damage is inconsistant and when present, milder than in the telencephalon, diencephalon and rostral brain stem. Cerebellar injury was observed in 3 of 4 PGI rats following 5 minutes of reperfusion but in none of the rats after 90 min of reperfusion. To evaluate a time between these two extremes (5 and 90 min), the present investigation used the PGI model to study the effects of ischemia on the ultrastructure of cerebellar Purkinje cells in rats that were sacrificed after 30 min of reperfusion. This time also was chosen because lactic acid that is thought to contribute to ischemic cell changes in PGI is at a maximum after 30 min of reperfusion.

PPAR-γ agonist rosiglitazone decreases focal cerebral ischemia-induced inflammation and brain damage in adult mice

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S94-S94
Author(s):  
Kudret Tureyen ◽  
Ramya Sundaresan ◽  
Kellie Bowen ◽  
Raghu Vemuganti
Keyword(s):  
Cerebral Ischemia ◽  
Brain Damage ◽  
Focal Cerebral Ischemia ◽  
Adult Mice ◽  
Ppar Γ
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