Investigation into the Catalytic Performance of Cu(II) Supported Graphene Quantum Dots Modified NiFe2O4 as a Proficient Nano-Catalyst in the Synthesis of Propargylasmines

Composites of gold nanoparticles and graphene quantum dots (AuNPs/GQDs) exhibit excellent dispersibility in aqueous solutions. Thus, it is difficult to separate them from wet reaction systems when they are used as catalysts. To resolve this issue, in this study, an AuNPs/GQDs composite was immobilized on silicon dioxide through the hydrothermal method, which involved the formation of an amide bond between the surface GQDs of the AuNPs/GQDs composite and the amino group of the silane. The as-synthesized AuNPs/GQDs/SiO2 composite was found to be suitable for use as a heterogeneous catalyst for the oxidation of veratryl alcohol in water and exhibited catalytic activity comparable to that of bare AuNPs/GQDs as well as better recyclability.

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Understanding of Catalytic ROS Generation From Defect-Rich Graphene Quantum-Dots for Therapeutic Effects in Tumor Microenvironment

10.21203/rs.3.rs-657051/v1 ◽

2021 ◽

Author(s):

Xichu Wang ◽

Chuangang Hu ◽

Zi (Sophia) Gu ◽

Liming Dai

Keyword(s):

Quantum Dots ◽

Tumor Microenvironment ◽

Catalytic Mechanism ◽

Defect Density ◽

Low Cost ◽

Graphene Quantum Dots ◽

Catalytic Efficiency ◽

Catalytic Performance ◽

Ros Generation ◽

Therapeutic Effects

Abstract Owing to their low cost, high catalytic efficiency and biocompatibility, carbon-based metalfree catalysts (C-MFCs) have attracted intense interest for various applications, ranging from energy through environmental to biomedical technologies. While considerable efforts and progress have been made in mechanistic understanding of C-MFCs for non-biomedical applications, their catalytic mechanism for therapeutic effects has rarely been investigated. In this study, defect-rich graphene quantum dots (GQDs) were developed as C-MFCs for efficient ROS generation, specifically in the H2O2 -rich tumor microenvironment to cause multi-level damage of subcellular components (even in nuclei). While a desirable anti-cancer performance was achieved, the catalytic performance was found to strongly depend on the defect density. It is for the first time that the defect-induced catalytic generation of ROS by C-MFCs in the tumor microenvironment was demonstrated and the associated catalytic mechanism was elucidated. This work opens a new avenue for the development of safe and efficient catalytic nanomedicine.

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Efficient synthesis of xanthene derivatives using carboxyl functionalized graphene quantum dots as an acidic nano-catalyst under microwave irradiation

RSC Advances ◽

10.1039/c5ra19645k ◽

2015 ◽

Vol 5 (107) ◽

pp. 88202-88208 ◽

Cited By ~ 12

Author(s):

Ashkan Shomali ◽

Hassan Valizadeh ◽

Alireza Banan ◽

Rahim Mohammad-Rezaei

Keyword(s):

Quantum Dots ◽

Microwave Irradiation ◽

Graphene Quantum Dots ◽

Coupling Reaction ◽

Functionalized Graphene ◽

Efficient Synthesis ◽

Acidic Catalyst ◽

Nano Catalyst ◽

Xanthene Derivatives ◽

Benzaldehyde Derivatives

Carboxyl functionalized graphene quantum dots (CGQDs) were applied as an efficient acidic catalyst for the coupling reaction of 2-naphthole and benzaldehyde derivatives for the preparation of 14H-dibenzo xanthene derivatives.

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Enhanced Fenton-like catalytic performance of N-doped graphene quantum dot incorporated CuCo2O4

New Journal of Chemistry ◽

10.1039/c8nj00219c ◽

2018 ◽

Vol 42 (11) ◽

pp. 9209-9220 ◽

Cited By ~ 10

Author(s):

Mohsen Nekoeinia ◽

Farideh Salehriahi ◽

Omran Moradlou ◽

Hojjat Kazemi ◽

Saeed Yousefinejad

Keyword(s):

Quantum Dots ◽

Quantum Dot ◽

Solvothermal Method ◽

Graphene Quantum Dots ◽

Catalytic Performance ◽

Heterogeneous Fenton ◽

Graphene Quantum Dot ◽

Doped Graphene

In the present study, a novel nanocomposite based on CuCo2O4 and N-doped graphene quantum dots (N-GQDs) as an iron-free heterogeneous Fenton-like catalyst was prepared by a two-step solvothermal method.

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Nitrogen-doped graphene quantum dots anchored on NiFe layered double-hydroxide nanosheets catalyze the oxygen evolution reaction

New Journal of Chemistry ◽

10.1039/d0nj03537h ◽

2020 ◽

Vol 44 (41) ◽

pp. 17744-17752

Author(s):

Qibing Dong ◽

Chao Shuai ◽

Zunli Mo ◽

Zhenyu Liu ◽

Guigui Liu ◽

...

Keyword(s):

Quantum Dots ◽

Oxygen Evolution ◽

Layered Double Hydroxide ◽

Oxygen Evolution Reaction ◽

Graphene Quantum Dots ◽

Catalytic Performance ◽

Nitrogen Doped ◽

Nitrogen Doped Graphene ◽

Doped Graphene ◽

Double Hydroxide

N-GQDs/NiFe-LDH layered nanosheet structure has excellent OER catalytic performance.

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Engineered N-doped graphene quantum dots/CoFe2O4 spherical composites as a robust and retrievable catalyst: fabrication, characterization, and catalytic performance investigation in microwave-assisted synthesis of quinoline-3-carbonitrile derivatives

RSC Advances ◽

10.1039/d1ra05739a ◽

2021 ◽

Vol 11 (55) ◽

pp. 34724-34734

Author(s):

Pouria Babaei ◽

Javad Safaei-Ghomi

Keyword(s):

Quantum Dots ◽

Graphene Quantum Dots ◽

Catalytic Performance ◽

Microwave Assisted Synthesis ◽

Microwave Assisted ◽

Doped Graphene

Sustainable fabrication of spherical N-GQDs/CoFe2O4 nanocomposites as a novel magnetically retrievable catalyst for the synthesis of quinoline-3-carbonitrile derivatives has been developed.

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Understanding of catalytic ROS generation from defect-rich graphene quantum-dots for therapeutic effects in tumor microenvironment

Journal of Nanobiotechnology ◽

10.1186/s12951-021-01053-6 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Xichu Wang ◽

Chuangang Hu ◽

Zi Gu ◽

Liming Dai

Keyword(s):

Quantum Dots ◽

Tumor Microenvironment ◽

Catalytic Mechanism ◽

Defect Density ◽

Low Cost ◽

Graphene Quantum Dots ◽

Catalytic Efficiency ◽

Catalytic Performance ◽

Ros Generation ◽

Therapeutic Effects

AbstractOwing to their low cost, high catalytic efficiency and biocompatibility, carbon-based metal-free catalysts (C-MFCs) have attracted intense interest for various applications, ranging from energy through environmental to biomedical technologies. While considerable effort and progress have been made in mechanistic understanding of C-MFCs for non-biomedical applications, their catalytic mechanism for therapeutic effects has rarely been investigated. In this study, defect-rich graphene quantum dots (GQDs) were developed as C-MFCs for efficient ROS generation, specifically in the H2O2-rich tumor microenvironment to cause multi-level damages of subcellular components (even in nuclei). While a desirable anti-cancer performance was achieved, the catalytic performance was found to strongly depend on the defect density. It is for the first time that the defect-induced catalytic generation of ROS by C-MFCs in the tumor microenvironment was demonstrated and the associated catalytic mechanism was elucidated. This work opens a new avenue for the development of safe and efficient catalytic nanomedicine.

Download Full-text