Octyl syringate is preferentially cytotoxic to cancer cells via lysosomal membrane permeabilization and autophagic flux inhibition

2021 ◽  
Author(s):  
Minho Won ◽  
Sunkyung Choi ◽  
Seonghye Cheon ◽  
Eun-Mi Kim ◽  
Taeg Kyu Kwon ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Membrane Permeabilization ◽  
Lysosomal Membrane ◽  
Autophagic Flux ◽  
Lysosomal Membrane Permeabilization

Lysosomal membrane permeabilization as a cell death mechanism in cancer cells

2018 ◽  
Vol 46 (2) ◽  
pp. 207-215 ◽  
Author(s):  
Ana Serrano-Puebla ◽  
Patricia Boya
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Proteolytic Enzymes ◽  
Hydrolytic Enzymes ◽  
Membrane Permeabilization ◽  
Lysosomal Membrane ◽  
Lysosomal Membrane Permeabilization ◽  
Regulated Cell Death ◽  
Cathepsin Activity ◽  
Intracellular Cascades

Lysosomes are acidic organelles that contain hydrolytic enzymes that mediate the intracellular degradation of macromolecules. Damage of these organelles often results in lysosomal membrane permeabilization (LMP) and the release into the cytoplasm of the soluble lysosomal contents, which include proteolytic enzymes of the cathepsin family. This, in turn, activates several intracellular cascades that promote a type of regulated cell death, called lysosome-dependent cell death (LDCD). LDCD can be inhibited by pharmacological or genetic blockade of cathepsin activity, or by protecting the lysosomal membrane, thereby stabilizing the organelle. Lysosomal alterations are common in cancer cells and may increase the sensitivity of these cells to agents that promote LMP. In this review, we summarize recent findings supporting the use of LDCD as a means of killing cancer cells.

A facile composite nanoparticle promoted by photoelectron transfer and consumption for tumor combination therapy

2020 ◽  
Vol 4 (10) ◽  
pp. 3047-3056
Author(s):  
Yahui Zhang ◽  
Weizhou Sha ◽  
Yang Liu ◽  
Wei Wang ◽  
Zhi Yuan
Keyword(s):  
Membrane Potential ◽  
Combination Therapy ◽  
Cancer Cells ◽  
Mitochondrial Membrane Potential ◽  
Mitochondrial Membrane ◽  
Membrane Permeabilization ◽  
Lysosomal Membrane ◽  
Lysosomal Membrane Permeabilization ◽  
Composite Nanoparticle ◽  
Mitochondrial Death Pathway

BTCu NPs can cause significant lysosomal membrane permeabilization (LMP) and mitochondrial membrane potential depolarization, thus indicating a lysosomal–mitochondrial death pathway in cancer cells.

3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages

2020 ◽  
Vol 265 ◽  
pp. 114697
Author(s):  
Ning Liu ◽  
Ying Yang ◽  
Jingqing Chen ◽  
Hai Jia ◽  
Yunchang Zhang ◽  
...  
Keyword(s):  
Membrane Permeabilization ◽  
Lysosomal Membrane ◽  
Autophagic Flux ◽  
Lysosomal Membrane Permeabilization

scholarly journals Oleocanthal and oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells

2019 ◽  
Author(s):  
Limor Goren ◽  
George Zhang ◽  
Susmita Kaushik ◽  
Paul Breslin ◽  
Yi-Chieh Nancy Du ◽  
...  
Keyword(s):  
Olive Oil ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Virgin Olive Oil ◽  
Membrane Permeabilization ◽  
Lysosomal Membrane ◽  
Selective Toxicity ◽  
Virgin Olive Oils ◽  
Lysosomal Membrane Permeabilization ◽  
Olive Oils

AbstractOleocanthal is a phenolic compound found in varying concentrations in extra virgin olive oil Oleocanthal has been shown to be active physiologically, benefiting several diseased states by conferring anti-inflammatory and neuroprotective benefits. Recently, we and other groups have demonstrated its specific and selective toxicity toward cancer cells; however, the mechanism leading to cancer cell death is still disputed. The current study demonstrates that oleocanthal, as well as naturally oleocanthal-rich extra virgin olive oils, induced damage to cancer cells’ lysosomes leading to cellular toxicityin vitroandin vivo. Lysosomal membrane permeabilization following oleocanthal treatment in various cell lines was assayed via three complementary methods. Additionally, we found oleocanthal treatment reduced tumor burden and extended lifespan of mice engineered to develop pancreatic neuroendocrine tumors. Finally, following-up on numerous correlative studies demonstrating consumption of olive oil reduces cancer incidence and morbidity, we observed that extra virgin olive oils naturally rich in oleocanthal sharply reduced cancer cell viability and induced lysosomal membrane permeabilization while oleocanthal-poor oils did not. Our results are especially encouraging since tumor cells often have larger and more numerous lysosomes, making them especially vulnerable to lysosomotropic agents such as oleocanthal.

scholarly journals (-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells

PLoS ONE ◽  
2019 ◽  
Vol 14 (8) ◽  
pp. e0216024 ◽  
Author(s):  
Limor Goren ◽  
George Zhang ◽  
Susmita Kaushik ◽  
Paul A. S. Breslin ◽  
Yi-Chieh Nancy Du ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Membrane Permeabilization ◽  
Lysosomal Membrane ◽  
Lysosomal Membrane Permeabilization ◽  
Olive Oils
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