The function of the simulation sweating device when done the experiment of dynamic moisture transfer based on Munsell color index was needed to simulate the state of the human body sweating as far as possible, the performance of the simulation skin would directly affect the stability of experimental results. This paper by selecting the four kinds of materials as an alternative of the simulation skin had carried out the experiment of dynamic moisture transfer based on Munsell color index and had done the analysis of variance of experimental results, and had found that results were significantly different when using different simulation skins. Further had done the test of the preserving water rate of seven representative materials, test results show that: the 2 # simulated skin 95% cotton knitted +fabric 5% op had the best preserving water performance, the 2 # simulated skin 95% cotton knitted +fabric 5% op could been chosen as the outer layer of simulated skin .the 6 #, faux suede had better similarity with morphology of human skin tissue. So, it could be chosen as in the layer of the simulated skin.