Antimicrobial and wound healing activities of electrospun nanofibers based on functionalized carbohydrates and proteins

Cellulose ◽  
2022 ◽  
Author(s):  
Mehran Alavi ◽  
Ali Nokhodchi
Keyword(s):  
Wound Healing ◽  
Electrospun Nanofibers

scholarly journals Nanostructured Fibers Containing Natural or Synthetic Bioactive Compounds in Wound Dressing Applications

Materials ◽  
2020 ◽  
Vol 13 (10) ◽  
pp. 2407 ◽  
Author(s):  
Alexa-Maria Croitoru ◽  
Denisa Ficai ◽  
Anton Ficai ◽  
Natalia Mihailescu ◽  
Ecaterina Andronescu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Electrospun Nanofibers ◽  
Natural Compounds ◽  
Electrospinning Process ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Skin Substitutes ◽  
Bioactive Constituents ◽  
Electrospinning Method

The interest in wound healing characteristics of bioactive constituents and therapeutic agents, especially natural compounds, is increasing because of their therapeutic properties, cost-effectiveness, and few adverse effects. Lately, nanocarriers as a drug delivery system have been actively investigated and applied in medical and therapeutic applications. In recent decades, researchers have investigated the incorporation of natural or synthetic substances into novel bioactive electrospun nanofibrous architectures produced by the electrospinning method for skin substitutes. Therefore, the development of nanotechnology in the area of dressings that could provide higher performance and a synergistic effect for wound healing is needed. Natural compounds with antimicrobial, antibacterial, and anti-inflammatory activity in combination with nanostructured fibers represent a future approach due to the increased wound healing process and regeneration of the lost tissue. This paper presents different approaches in producing electrospun nanofibers, highlighting the electrospinning process used in fabricating innovative wound dressings that are able to release natural and/or synthetic substances in a controlled way, thus enhancing the healing process.

scholarly journals Recent advances in electrospun nanofibers for wound healing

Nanomedicine ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. 1335-1352 ◽  
Author(s):  
Shixuan Chen ◽  
Bing Liu ◽  
Mark A Carlson ◽  
Adrian F Gombart ◽  
Debra A Reilly ◽  
...  
Keyword(s):  
Wound Healing ◽  
Electrospun Nanofibers ◽  
Recent Advances

Co-electrospun nanofibers of PVA-SbQ and Zein for wound healing

2015 ◽  
Vol 132 (39) ◽  
pp. n/a-n/a ◽  
Author(s):  
Jing Cui ◽  
Liying Qiu ◽  
Yuyu Qiu ◽  
Qingqing Wang ◽  
Qufu Wei
Keyword(s):  
Wound Healing ◽  
Electrospun Nanofibers

Electrospun nanofibers in wound healing

2020 ◽  
Vol 29 ◽  
pp. 1-6 ◽  
Author(s):  
Melisa Anne Sylvester ◽  
Farahnaz Amini ◽  
Chung Keat Tan
Keyword(s):  
Wound Healing ◽  
Electrospun Nanofibers

Study on scar repair and wound nursing of chitosan-based composite electrospun nanofibers in first aid of burn

2021 ◽  
Vol 11 (8) ◽  
pp. 1420-1427
Author(s):  
Qing Liu ◽  
Liping Yang ◽  
Qingrong Peng
Keyword(s):  
Wound Healing ◽  
Cell Injury ◽  
Antioxidant Properties ◽  
Vascular Endothelial Cell ◽  
Radical Scavenging ◽  
Electrospun Nanofibers ◽  
First Aid ◽  
Oxygen Free Radical ◽  
Burn Patients ◽  
Clinical Experiments

Bacterial infection and oxidative stress are serious complications in emergency burn patients, as the increase of oxygen free radicals in burn wounds can aggravate vascular endothelial cell injury, make the wounds ischemic and hypoxic, and delay wound healing. Traditional dressings cannot meet the first-aid needs of burn patients. In this study, polycaprolactone/chitosan (PCL/CS) was used as an electrospun nanofiber matrix, and curcumin (CUR), a molecule with excellent anti-inflammatory and antioxidant properties, was introduced to construct polycaprolactone/ chitosan graft copolymer-zein-curcumin electrospun nanofibers (PCL/CS-ZE-CUR). The results of clinical experiments suggest that compared with traditional dressings, based on the excellent mechanical properties and antibacterial activity of PCL/CS, the new dressing can exhibit oxygen free radical-scavenging abilities of CUR to accelerate wound healing and is expected to provide a beneficial upgrade for wound emergency care.

Diltiazem-loaded electrospun nanofibers as a new wound dressing: fabrication, characterization, and experimental wound healing

2020 ◽  
pp. 1-14
Author(s):  
Ramin Seyedian ◽  
Elham Shabankareh Fard ◽  
Seyede Sahar Hashemi ◽  
Hossein Hasanzadeh ◽  
Majid Assadi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Electrospun Nanofibers

Bioactive anti-oxidative polycaprolactone/gelatin electrospun nanofibers containing selenium nanoparticles/vitamin E for wound dressing applications

2021 ◽  
pp. 088532822110013
Author(s):  
Mohsen Doostmohammadi ◽  
Hamid Forootanfar ◽  
Mojtaba Shakibaie ◽  
Masoud Torkzadeh-Mahani ◽  
Hamid-Reza Rahimi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Vitamin E ◽  
Electrospun Nanofibers ◽  
Inflammatory Cells ◽  
Selenium Nanoparticles ◽  
In Vivo Studies ◽  
Solution Ph ◽  
High Level ◽  
Biogenic Selenium Nanoparticles

In this study, polycaprolactone/gelatin (PCL/GEL) electrospun nanofibers containing biogenic selenium nanoparticles (Se NPs) and Se NPs/vitamin E (VE) with average diameters of 397.8 nm and 279.5 nm, respectively (as determined by SEM inspection) were prepared and their effect on wound healing was evaluated using in-vivo studies. The energy dispersive X-ray (EDX) mapping, TEM micrograph, and FTIR spectra of the prepared nanofibers strongly demonstrated well entrapment of Se NPs and VE into scaffolds. An amount of 57% Se NPs and 43% VE were gradually released from PCL/GEL/Se NPs/VE scaffold after 4 days immersion in PBS solution (pH 7.4). The both PCL/GEL/Se NPs and PCL/GEL/Se NPs/VE scaffolds supported 3T3 cell proliferation and attachment as confirmed by MTT assay and SEM imaging. Complete re-epithelialization, low level of edema and inflammatory cells in coordination with high level of oriented collagens demonstrated the wound healing activity of PCL/GEL/Se NPs/VE. Besides, significant antioxidant efficacy of PCL/GEL/Se NPs and PCL/GEL/Se NPs/VE scaffolds was demonstrated according to GSH and MDA assays. To sum up, the prepared PCL/GEL/Se NPs/VE scaffold in the present study represented suitable healing effect on animal model which candidate it for further studies.

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